Basal Cell Carcinoma with Mixed Histology: A Possible Pathogenesis for Recurrent Skin Cancer

Cohen, Philip R.; Schulze, Keith E.; Nelson, Bruce R.

doi:10.1111/j.1524-4725.2006.32110.x

Cited by 80 publications

(127 citation statements)

References 81 publications

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“…The incidence of BCCs with mixed histology is varied between 11% and 43% (54). BCC with mixed histology is most commonly found on the nose, followed by the ear, cheek, and scalp.…”

Section: Bcc With Mixed Histology Bcc With Mixed Histology (Bcc-mh)mentioning

confidence: 99%

“…Subsequently, the cancer may recur if the initial treatment for the diagnosed nonaggressive tumor subtype is inadequate for the undiscovered aggressive carcinoma. Clinical recurrence of cancer results when there has been persistence of the original tumor secondary to inadequate eradication (54). The recurrence rate for BCC lesions with positive margins calculated from the aggregated data is 27 percent (72).…”

Section: Recurrency Of Bccmentioning

confidence: 99%

“…The recurrence rate for BCC lesions with positive margins calculated from the aggregated data is 27 percent (72). The reported percent of BCC recurrence varies depending on the treatment modality (54). Recurrent BCC (rBCC) is known to be a high-risk tumour with a worse prognosis than primary BCC (50,59,76,100).…”

Section: Recurrency Of Bccmentioning

confidence: 99%

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An Overview on Basal Cell Carcinoma

Avcı¹

2011

Skin Cancer Overview

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“…The incidence of BCCs with mixed histology is varied between 11% and 43% (54). BCC with mixed histology is most commonly found on the nose, followed by the ear, cheek, and scalp.…”

Section: Bcc With Mixed Histology Bcc With Mixed Histology (Bcc-mh)mentioning

confidence: 99%

Section: Recurrency Of Bccmentioning

confidence: 99%

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An Overview on Basal Cell Carcinoma

Avcı¹

2011

Skin Cancer Overview

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“…11 Possible reasons for non-recurrence may include an immune reaction, inflammation or devitalization of the residual tumor tissue. 12 Indeed, some investigators have reported that after a 5 or 10-year follow-up period, not all incompletely excised BCC resulted in recurrences. The highest recurrence rate in BCC was recorded two years after surgery.…”

Section: Introductionmentioning

confidence: 99%

Does incomplete excision of basal cell carcinoma of the eyelid mean tumor recurrence?

Jankovic

Kovačević

Visnjic

et al. 2010

An. Bras. Dermatol.

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Introduction: Basal cell carcinoma is the most common tumor of the eyelid. In this region, reconstruction is complex and damage to healthy tissue should be minimal. Objective: To define the relationship between margin clearance at excision and the recurrence rate of basal cell carcinoma of the eyelid. Methods: This prospective study was conducted with 111 patients submitted to surgery for basal cell carcinoma of the eyelid between 2001 and 2003 and followed up for a period of five years. The patients were evaluated according to age, tumor site, recurrence rate and margin clearance at excision. Results: No significant association was found between incomplete tumor excision and recurrence except in patients under 56 years of age, female patients and in the case of tumors of the medial canthus. Conclusion: A risk of recurrence in incompletely excised basal cell carcinomas of the eyelid was only confirmed in younger patients, females and for tumors of the medial canthus. Keywords: Basal cell carcinoma; eyelid; recurrence.Resumo: Introdução: O carcinoma basocelular é o tumor mais comum entre os tumores das pálpebras. Nesta região, a reconstrução é complexa e recomenda-se que haja perda mínima de tecido saudável. Objetivo: Para definir a relação entre margem livre de tumor na excisão e taxa de recidiva do carcinoma basocelular das pálpebras. Métodos: Este estudo prospectivo incluiu 111 pacientes operados para remoção de carcinoma basocelular das pálpebras no período de 2001 a 2003, com acompanhamento subsequente de 5 anos. Os pacientes foram avaliados de acordo com a idade, localização do tumor, taxa de recidiva, e margem livre de tumor na excisão. Resultados: Não se encontrou associação significativa entre a excisão incompleta do tumor e casos de recidiva, exceto em pacientes com idade inferior a 56 anos, pacientes do sexo feminino e em tumores do canto medial. Conclusão: Um risco maior de recidiva de carcinoma basocelular das pálpebras com excisão incompleta foi confirmado estatisticamente apenas em pacientes mais jovens, em mulheres, e nos tumores do canto interno.

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“…Morfealiknende og infiltrerende basalcellekarsinomer, derimot, har et mer uforutsigbart forløp med en vekst som kjennetegnes av til dels lange, klinisk ikke-synlige tumorutløpere i én eller flere retninger (11). Mange basalcellekarsinomer har flere histologiske vekstmønstre i en og samme lesjon (12).…”

Section: Histologiunclassified