Histologic comparison of tumor necrosis factor-α inhibitor–induced psoriasis and psoriasis vulgaris

Hu, Jeffrey Zhu; Billings, Steven D.; Yan, Di; Fernandez, Anthony P.

doi:10.1016/j.jaad.2020.01.006

Cited by 21 publications

(19 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They identified that the presence of at least three or more eosinophils per section represented the most clinically useful histopathologic finding to support a diagnosis of paradoxical psoriasis vs idiopathic psoriasis. However, they did not specify the subtype of psoriasis either in the cases or in the control group 11 . By contrast, none of our cases of plaque psoriasis or palmoplantar pustulosis showed eosinophils in dermal infiltrates.…”

Section: Discussioncontrasting

confidence: 58%

“…There have been reports of paradoxical induction or worsening of psoriasis specially during treatment with antitumor necrosis factor alpha (TNFα) agents 1‐12 . Paradoxical psoriasiform reactions include de novo psoriasis and exacerbation of pre‐existing psoriasis 2 .…”

Section: Introductionmentioning

confidence: 99%

“…

There have been reports of paradoxical induction or worsening of psoriasis specially during treatment with antitumor necrosis factor alpha (TNFα) agents. [1][2][3][4][5][6][7][8][9][10][11][12] Paradoxical psoriasiform reactions include de novo psoriasis and exacerbation of pre-existing psoriasis. 2 Prevalence data, histopathologic, and comparative analysis with non-induced psoriasis are limited in the literature.

…”

mentioning

confidence: 99%

See 2 more Smart Citations

Histopathologic study of paradoxical psoriasis induced by antitumor necrosis factor alpha therapy: Is it true psoriasis?

et al. 2020

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

“…

…”

mentioning

confidence: 99%

See 1 more Smart Citation

Histopathologic study of paradoxical psoriasis induced by antitumor necrosis factor alpha therapy: Is it true psoriasis?

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Although PP clinically may resemble classical psoriasis, there is evidence that it represents a distinct pathological entity [ 28 ], and different underlying pathogenic mechanisms may be involved in classical and paradoxical psoriasis. Classical psoriasis is a T-cell mediated autoimmune disease driven by TNF, while in contrast, PP is caused by the absence of TNF and represents a type-I interferon (IFN)-driven innate inflammation [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-Specific Clinical and Genetic Markers

Bucalo

Rega

Zangrilli

et al. 2020

IJMS

View full text Add to dashboard Cite

Paradoxical psoriasis (PP) may occur during treatment with anti-tumor necrosis factor-alpha (TNF-α) drugs in various chronic immune-mediated diseases, mainly inflammatory bowel diseases (IBD) and psoriasis. In this study, clinical and genetic characteristics of PP arising in IBD and psoriatic patients were investigated to identify disease-specific markers of the paradoxical effect. A total of 161 IBD and psoriatic patients treated with anti-TNF-α drugs were included in the study. Of these patients, 39 developed PP. All patients were characterized for the main clinical–pathologic characteristics and genotyped for six candidate single nucleotide polymorphisms (SNPs) selected for their possible role in PP susceptibility. In IBD patients, the onset of PP was associated with female sex, presence of comorbidities, and use of adalimumab. IBD patients with PP had a higher frequency of the TNF-α rs1799964 rare allele (p = 0.006) compared with cases without the paradoxical effect, and a lower frequency of the human leucocyte antigen (HLA)-Cw06 rs10484554 rare allele (p = 0.03) compared with psoriatic patients with PP. Overall, these findings point to specific clinical and genetic characteristics of IBD patients with PP and provide data showing that genetic variability may be related to the paradoxical effect of anti-TNF-α drugs with possible implications into clinical practice.

show abstract

“…This allowed for the specific targeting of parts of the immune system, rather than suppression of the entire immune system, leading to a favorable efficacy and safety profile (53,54). However, some studies revealed that they might cause adverse events like infection and idiopathic psoriasis (6,55). Moreover, a single drug was unable to meet the treatment of complex diseases such as psoriasis, while the combination might have an increasing risk of AEs.…”

Section: Discussionmentioning

confidence: 99%

Evidence and potential mechanisms of traditional Chinese medicine for the treatment of psoriasis vulgaris: a systematic review and meta-analysis

Dai

et al. 2020

Journal of Dermatological Treatment

View full text Add to dashboard Cite

Psoriasis vulgaris (PV) not only affects patients' skin health but also increases the risk of coronary heart disease and diabetes, which brings both physical and mental harms. Its pathogenesis is complex, and the multitarget effect of traditional Chinese medicine (TCM) is especially advantageous. Because a considerable number of randomized controlled trials related to TCM exhibit design defects, small sample size, or inadequate intervention time, so the status of TCM in the treatment of PV cannot be fully clarified. We reviewed the controlled clinical trials published over the past decade and selected 17 high-quality articles from over 2000 papers. The results suggest that TCM might be beneficial for decrease in PASI scores, thus, TCM might be an effective alternative therapy for PV management. The safety of TCM on PV was also assessed in our analysis. The more strictly designed and long-term observations of TCM for PV are supposed to be conducted in the future.

show abstract

Histologic comparison of tumor necrosis factor-α inhibitor–induced psoriasis and psoriasis vulgaris

Cited by 21 publications

References 18 publications

Histopathologic study of paradoxical psoriasis induced by antitumor necrosis factor alpha therapy: Is it true psoriasis?

Histopathologic study of paradoxical psoriasis induced by antitumor necrosis factor alpha therapy: Is it true psoriasis?

Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-Specific Clinical and Genetic Markers

Evidence and potential mechanisms of traditional Chinese medicine for the treatment of psoriasis vulgaris: a systematic review and meta-analysis

Contact Info

Product

Resources

About