Histologic assessment of mesh fixation following laser-assisted tissue soldering in a lapine model

Abstract

Collagen-based tissue soldering permits normal wound healing and may mitigate use of staples. Further development of this strategy is warranted.

Temperature-controlled laser-soldering system and its clinical application for bonding skin incisions

“…Later, in order to reduce the thermal damage and increase the LTW strength, biological protein-based solders were introduced. LTS has been carried out with different types of lasers, together with various types of biological solders, such as fibrinogen, 3 albumin, 4 collagen, 5 or chitosan. 6 The solder was usually applied on the surface to be joined, and then laser energy was used to adhere the underlying wound edges together, and at the same time attaching the solder to the tissue surface, resulting in increased strength and generating a watertight seal.…”

Novel Laser-Activated Solder for Sealing Corneal Wounds

“…Furthermore, thermocoupled measurements (model 91100 to 50 Dual Thermocouple Thermometer using type K thermocouples; Digi-Sense, Laudium, South Africa) determined that the temperature measured at the solder-tissue interface was adequate for melting the solder collagen but remained well below that required for irreversible protein denaturation in the cornea. 44 Rabbit corneas are thinner than human corneas, making it difficult to create a valved, self-sealing incision. To test the sealing capacity of the collagen solder for this animal model, a wound was created that would leak continuously or seal spontaneously.…”

Preliminary Assessment of Photoactivated Antimicrobial Collagen on Bioburden in a Murine Pressure Ulcer Model

“…It is hydrophilic and behaves as a postoperative adhesion preventative when placed intraabdominally. 20,22,23 The material can be used as a carrier for biologically relevant molecules and FIG. 7.…”

“…The material is biocompatible and is pliable. 21 The material conforms to any surface to which it is applied. It is hydrophilic and behaves as a postoperative adhesion preventative when placed intraabdominally.…”