Histologic and Ultrastructural Features of Explanted Arenberg Shunts

Cohen, Eric J.; Mattox, Douglas E.

doi:10.1001/archotol.1994.01880270072012

Cited by 6 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These facts are exemplified in studies with membrane/GBR healing in the dog model, where reported an onset of A-R-F remodeling of woven bone at between 2 and 4 mos post-surgery. Likewise, in healing of 0.6-mm-diameter holes in rabbit tibiae, A-R-F did not start in the woven bone until 6 wks after surgery (Schenk and Hunziker, 1994). Meanwhile, A-R-F of pre-existing damaged bone would have started immediately or soon after surgery.…”

Section: When Does Healing End? Remodeling Of New Woven Bone Vs Damamentioning

confidence: 90%

“…A common feature of any gap, pore, or other defect between bone and implant is that it will fill with a blood clot soon after surgery. Then, if the implant is stable in the site, bone heals in the gap by a process that has been called screw-shaped implant implant with steps or fins porous-coated implant implant I I clot I bone intramembranous bone formation (Schenk and Hunziker, 1994) and de novo bone formation (Davies, 1998). (I will use the terms synonymously.)…”

Section: Healing In Gaps Pores or Other Spaces Between Bone And Impmentioning

confidence: 99%

“…(I will use the terms synonymously.) Schenk and Hunziker (1994) reported on intramembranous bone healing in small holes (0.6 mm diameter) drilled in rabbit cortical bone. studied such healing in large (ca.…”

Section: Healing In Gaps Pores or Other Spaces Between Bone And Impmentioning

confidence: 99%

“…If the end of healing is defined as complete restoration of the original bone architecture, then even 3 mos (or 2 sigma) of healing is inadequate in the rabbit, as seen in the example in Fig. 5 (Schenk and Hunziker, 1994); the original tibial bone architecture is not yet fully restored 6 mos after the drilling of a 0.6-mm hole. Since the rabbit heals faster than the dog or the human (Roberts et al, 1987), cortical bone healing in the dog and human would therefore take more than 6 mos to finish.…”

Section: When Does Healing End? Remodeling Of New Woven Bone Vs Damamentioning

confidence: 99%

See 3 more Smart Citations

In Vivo Bone Response to Biomechanical Loading at the Bone/Dental-Implant Interface

1999

View full text Add to dashboard Cite

Since dental implants must withstand relatively large forces and moments in function, a better understanding of in vivo bone response to loading would aid implant design. The following topics are essential in this problem. (1) Theoretical models and experimental data are available for understanding implant loading as an aid to case planning. (2) At least for several months after surgery, bone healing in gaps between implant and bone as well as in pre-existing damaged bone will determine interface structure and properties. The ongoing healing creates a complicated environment. (3) Recent studies reveal that an interfacial cement line exists between the implant surface and bone for titanium and hydroxyapatite (HA). Since cement lines in normal bone have been identified as weak interfaces, a cement line at a bone-biomaterial interface may also be a weak point. Indeed, data on interfacial shear and tensile "bond" strengths are consistent with this idea. (4) Excessive interfacial micromotion early after implantation interferes with local bone healing and predisposes to a fibrous tissue interface instead of osseointegration. (5) Large strains can damage bone. For implants that have healed in situ for several months before being loaded, data support the hypothesis that interfacial overload occurs if the strains are excessive in interfacial bone. While bone "adaptation" to loading is a long-standing concept in bone physiology, researchers may sometimes be too willing to accept this paradigm as an exclusive explanation of in vivo tissue responses during experiments, while overlooking confounding variables, alternative (non-mechanical) explanations, and the possibility that different types of bone (e.g., woven bone, Haversian bone, plexiform bone) may have different sensitivities to loading under healing vs. quiescent conditions.

show abstract

Section: When Does Healing End? Remodeling Of New Woven Bone Vs Damamentioning

confidence: 90%

Section: Healing In Gaps Pores or Other Spaces Between Bone And Impmentioning

confidence: 99%

Section: Healing In Gaps Pores or Other Spaces Between Bone And Impmentioning

confidence: 99%

Section: When Does Healing End? Remodeling Of New Woven Bone Vs Damamentioning

confidence: 99%

See 2 more Smart Citations

In Vivo Bone Response to Biomechanical Loading at the Bone/Dental-Implant Interface

1999

View full text Add to dashboard Cite

show abstract

“…On shunt revision, even polymeric silicon (Silastic) is encoated in a fibrous scar band, limiting the drainage potential of this biocompatible material [15]. Thus, more destructive surgery, such as ES removal, has recently been introduced [16,17].…”

Section: Discussionmentioning

confidence: 99%

Intraoperative Mitomycin C in Endolymphatic Sac Surgery for Ménière’s Disease: A Pilot Study

Yazawa¹,

Suzuki²,

Kitano³

et al. 1999

ORL

View full text Add to dashboard Cite

The long-term results of endolymphatic sac (ES) shunt surgery in Ménière’s disease have been reported to be unsatisfactory compared to the short-term results, probably because of fibrosis and/or reclosure of the incised ES. To solve this problem, we tried to apply mitomycin C (MMC) intraoperatively to the incised ES as used in trabeculectomy for glaucoma. MMC has an antiproliferative effect as well as an antineoplastic effect. Thus, it is expected that MMC would have a benefit to prevent rapid fibrosis and/or reclosure of the ES. MMC did not show any ototoxicity in our animal study and we started a clinical trial after being approved by the Ethics Committee for Human Research at our university. Fourteen patients with Ménière’s disease underwent ES mastoid shunt surgery with intraoperative application of MMC and they were followed up more than 6 months. No patients experienced vertigo, although some complained of slight dizziness. Five patients out of 14 showed remarkable hearing improvement by more than 10 dB, accompanied with decrease of tinnitus.

show abstract

A Review on Powder Bed Fusion Additive Manufacturing for Metallic Fixation Implants

Al-Tamimi

Alqahtani

Liu

et al. 2020

Virtual Prototyping &Amp; Bio Manufacturing in Medical Applications

View full text Add to dashboard Cite

Histologic and Ultrastructural Features of Explanted Arenberg Shunts

Cited by 6 publications

References 11 publications

In Vivo Bone Response to Biomechanical Loading at the Bone/Dental-Implant Interface

In Vivo Bone Response to Biomechanical Loading at the Bone/Dental-Implant Interface

Intraoperative Mitomycin C in Endolymphatic Sac Surgery for Ménière’s Disease: A Pilot Study

A Review on Powder Bed Fusion Additive Manufacturing for Metallic Fixation Implants

Contact Info

Product

Resources

About