Histologic and Biomechanical Evaluation of Osseointegrated Miniscrew Implants Treated with Ozone Therapy and Photobiomodulation at Different Loading Times

Yücesoy, Türker; Şeker, Elif Dilara; Cenkci, Ebru; Yay, Arzu Hanım; Alkan, Alper

doi:10.11607/jomi.7601

Cited by 12 publications

(20 citation statements)

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“…In the last few years, a renewed interest in the therapeutic potential of ozone has emerged. In particular, the focus is on the ability to promote wound healing, to attenuate the adverse effects of inflammation by reducing the oxidative activities of inflammatory cells, to express antimicrobial activities against various bacterial species and mycetes pathogenic for humans, and also against biofilm-producing and antibiotic-resistant bacteria, thus offering chances of overcoming antibiotic-resistance issues [30][31][32][33][34][35][36][37][38][39] (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

Ozone Gel in Chronic Periodontal Disease: A Randomized Clinical Trial on the Anti-Inflammatory Effects of Ozone Application

Colombo

Gallo

Garofoli

et al. 2021

Biology

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The search for new topical treatments able to display not only antimicrobial properties but also a multiplicity of other beneficial effects while expressing safe cytocompatibility toward host tissues is being progressively developed. Antiseptics represent an aid to the gold standard nonsurgical treatment Scaling-and-Root-Planing (SRP) for periodontal disease. This split-mouth study aims to assess the efficacy of the ozonized gel GeliO3 (Bioemmei Srl, Vicenza, Italy) plus SRP (experimental treatment), with respect to SRP + chlorhexidine gel. Ten participants were treated with SRP + chlorhexidine gel (control sites) and with SRP + ozone gel (trial sites). After 1 (T1) and 3 months (T2) from baseline (T0), patients were revisited. At each time-point, the following indexes were assessed: probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI), plaque index (PI), and bleeding on probing (BoP). It has been assessed that the use of the ozonized gel in addition to SRP did not show significant differences if compared to conventional SRP + chlorhexidine. Chlorhexidine was found to be more effective than ozone in reducing CAL and GI at T2. Ozone deserves consideration for its wide applicability in several clinical fields. In this connection, we also glance at the latest research on ozone therapy.

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Section: Discussionmentioning

confidence: 99%

Ozone Gel in Chronic Periodontal Disease: A Randomized Clinical Trial on the Anti-Inflammatory Effects of Ozone Application

Colombo

Gallo

Garofoli

et al. 2021

Biology

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“…The information of an orthodontic miniscrew was also imported and converted to a finite element model. Based on the previous research [22][23][24][25][26][27][28], we modified a C-implant and used it as an orthodontic miniscrew. A diameter of the orthodontic miniscrew we used was 1.6 mm, smaller than that of the original C-implant at 1.8 mm (Bio-Action screw (BA screw), Jin-Biomed co., Bucheon, Korea).…”

Section: Development Of Finite Element Modelmentioning

confidence: 99%

“…Previous studies have focused on the microstructural modification of the dental implant or the orthodontic miniscrew surfaces to facilitate the osseointegration between the surface of dental implant or orthodontic miniscrew and bone [23,24]. Recently, in addition to treating surface of the orthodontic miniscrew such as SLA treatment, ozone therapy and photobiomodulation were introduced for a better osseointegration process [25]. Another attempt to stimulate peri-implant osteogenesis by ultraviolet photofunctionalization was tried, but it did not enhance the biologic potential of orthodontic miniscrew [26].…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Surface Designs on the Rotational Resistance and Stability of Orthodontic Miniscrews: A Three-Dimensional Finite Element Study

Choi

Cho

et al. 2021

Sensors

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High orthodontic forces and various directions of applied forces can be associated with loosening of the screw anchorage in the bone. Screw designs have been modified to increase the stability of the miniscrews. This research evaluates the influence of three-designs on the stability of orthodontic miniscrews. A conventionally cylinder-type miniscrew design (Bio-Action screw, Jin-Biomed co., Bucheon, Korea) was set as a control, and three conditions were studied based on modifications of this control design. Condition-1 has narrowed threads in the upper part of the screw; Condition-2 has a notch at the middle part; and Condition-3 has the combination of Condition-1 and Condition-2. The moment required to unwind the miniscrew to five degrees is tested, and the moment generated at the cortical bone and the trabecular bone were calculated with finite element analysis. Compared to the control, all three conditions showed a higher moment required to unwind the miniscrew and a higher moment generated at the cortical bone. At the trabecular bone, condition-2 and -3 showed higher moment than the control, and condition-1 showed similar moment to the control. Condition-3 required a higher overall moment to unwind the miniscrew. These findings validate the design modifications used to increase the rotational resistance.

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“…Modern strategies to prevent implant-associated infections are geared towards treatments and technologies capable of preventing/resisting infections while promoting repair and osseous integration [21][22][23][24].The promotion of peri-implant bone-healing of endosseous implants by an ozonized oil has been experimentally studied in immunosuppressed rabbits [25]. A better osseointegration process in endosseous implants treated with photobiomodulation and ozone therapy has been described [26]. Modifications have been proposed to improve their integration but also to confer anti-infective properties [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

“…Osteoblasts cultured on ozone-ultraviolet-treated surfaces displayed a significantly higher expression of osteoblast markers, like bone morphogenetic protein 2, and osteocalcin [30]. Ozonized oils and other ozone treatments exhibited the capability to promote the bone integration of dental and orthopedic implants while expressing antimicrobial and even immunomodulatory effects [25,26,31]. However, the fungicidal potential of ozone therapy is still poorly explored.…”

Section: Introductionmentioning

confidence: 99%

Ozonized Gel Against Four Candida Species: A Pilot Study and Clinical Perspectives

et al. 2020

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Ozone therapy can display a wide range of clinical beneficial effects, including antimicrobial, immune-stimulant, analgesic, anti-hypoxic actions. However, there is still a paucity of data regarding the ozone fungicide activity. Oral Candida is the most common fungal infection in the mouth among denture wearers and people with weakened immune systems. In the case of generalized candidiasis or immunocompromised patients, systemic therapy is needed, while localized infections are treated with topic medications. However, many Candida strains are resistant to antifungal drugs. The aim of this preliminary analysis is to evaluate the antimycotic efficacy of a new ozonided oil (GeliO3), as a possible terapeutic alternative in local treatments of these infections, compared to chlorhexidine digluconate (Plak gel®). Chlorhexidine is a chemical synthesis disinfectant with a broad-spectrum antiseptic action, active against bacteria and fungi. Antimycotic activity was tested against the following four Candida species: C. albicans, C. parapsilosis, C. glabrata, C. tropicalis, through an agar diffusion method. No significant differences were found between the growth inhibition zone diameters of the ozonized gel and chlorhexidine. The results indicated that the ozonized gel may help to combat Candida infections. Moreover, useful applications could be used to counteract Candida colonization of endosseous implants.

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Histologic and Biomechanical Evaluation of Osseointegrated Miniscrew Implants Treated with Ozone Therapy and Photobiomodulation at Different Loading Times

Cited by 12 publications

References 0 publications

Ozone Gel in Chronic Periodontal Disease: A Randomized Clinical Trial on the Anti-Inflammatory Effects of Ozone Application

Ozone Gel in Chronic Periodontal Disease: A Randomized Clinical Trial on the Anti-Inflammatory Effects of Ozone Application

Effect of Different Surface Designs on the Rotational Resistance and Stability of Orthodontic Miniscrews: A Three-Dimensional Finite Element Study

Ozonized Gel Against Four Candida Species: A Pilot Study and Clinical Perspectives

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