Histogram Analysis of Renal Arterial Spin Labeling Perfusion Data Reveals Differences Between Volunteers and Patients With Mild Chronic Kidney Disease

Rossi, Cristina; Artunc, Ferruh; Martirosian, Petros; Schlemmer, Heinz Peter; Schick, Fritz; Boss, Andreas

doi:10.1097/rli.0b013e318257063a

Cited by 64 publications

(78 citation statements)

References 23 publications

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“…For example, in a recent study, a coefficient of variance of 9.2 and 7.1% for cortical perfusion and whole kidney perfusion was demonstrated [7]. A small number of studies have shown reduced perfusion in patients with CKD compared to controls [8,9], and in poorly functioning kidney transplants compared to transplants with better function [10,11,12]. …”

Section: Introductionmentioning

confidence: 99%

Non-Contrast Renal Magnetic Resonance Imaging to Assess Perfusion and Corticomedullary Differentiation in Health and Chronic Kidney Disease

Gillis

McComb

Patel

et al. 2016

Nephron

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Aims: Arterial spin labelling (ASL) MRI measures perfusion without administration of contrast agent. While ASL has been validated in animals and healthy volunteers (HVs), application to chronic kidney disease (CKD) has been limited. We investigated the utility of ASL MRI in patients with CKD. Methods: We studied renal perfusion in 24 HVs and 17 patients with CKD (age 22-77 years, 40% male) using ASL MRI at 3.0T. Kidney function was determined using estimated glomerular filtration rate (eGFR). T1 relaxation time was measured using modified look-locker inversion and ﬂow-sensitive alternating inversion recovery true-fast imaging and steady precession was performed to measure cortical and whole kidney perfusion. Results: T1 was higher in CKD within cortex and whole kidney, and there was association between T1 time and eGFR. No association was seen between kidney size and volume and either T1, or ASL perfusion. Perfusion was lower in CKD in cortex (136 ± 37 vs. 279 ± 69 ml/min/100 g; p < 0.001) and whole kidney (146 ± 24 vs. 221 ± 38 ml/min/100 g; p < 0.001). There was significant, negative, association between T1 longitudinal relaxation time and ASL perfusion in both the cortex (r = -0.75, p < 0.001) and whole kidney (r = -0.50, p < 0.001). There was correlation between eGFR and both cortical (r = 0.73, p < 0.01) and whole kidney (r = 0.69, p < 0.01) perfusion. Conclusions: Significant differences in renal structure and function were demonstrated using ASL MRI. T1 may be representative of structural changes associated with CKD; however, further investigation is required into the pathological correlates of reduced ASL perfusion and increased T1 time in CKD.

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Section: Introductionmentioning

confidence: 99%

Non-Contrast Renal Magnetic Resonance Imaging to Assess Perfusion and Corticomedullary Differentiation in Health and Chronic Kidney Disease

Gillis

McComb

Patel

et al. 2016

Nephron

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“…A number of recent studies have employed ASL in the assessment of kidney disease. In two separate studies, Rossi and Tan both used ASL to compare CKD patients (n=9 and n=5 respectively) with healthy volunteers and found that cortical perfusion levels were lower in CKD [25,26]. ASL has also been used in AKI; Dong et al reported a reduction in both cortical and medullary perfusion in a group of 11 patients with AKI mostly due to intrinsic renal disease [27].…”

Section: Arterial Spin Labellingmentioning

confidence: 99%

Imaging the kidney using magnetic resonance techniques

Mahmoud

Buchanan

Francis

et al. 2016

Current Opinion in Nephrology and Hypertension

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(2016) Imaging the kidney using magnetic resonance techniques: structure to function. Current Opinion in Nephrology and Hypertension, 25 (6). pp. 487-493. ISSN 1473-6543 Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/39487/1/REVIEW_RENAL_EPRINTS_ALL.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the University of Nottingham End User licence and may be reused according to the conditions of the licence. For more details see: http://eprints.nottingham.ac.uk/end_user_agreement.pdf A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. Recent findingsA number of MRI techniques have been developed that provide non-invasive measures of relevance to the pathophysiology of kidney disease. Diffusion-weighted imaging (DWI) has been used in chronic kidney disease (CKD) and renal transplantation, and appears promising as a measure of renal impairment and fibrosis. Longitudinal relaxation time (T1) mapping has been utilised in cardiac MRI to measure fibrosis and oedema; recent work suggests its potential for assessment of the kidney. Blood oxygen level dependent (BOLD) MRI to measure renal oxygenation has been extensively studied, but a number of other factors affect results making it hard to draw definite conclusions as to its utility as an independent measure. Phase contrast and arterial spin labelling (ASL) can measure renal artery blood flow and renal perfusion respectively without exogenous contrast, in contrast to dynamic contrast enhanced (DCE) studies. Current data on clinical use of such functional renal MR measures is largely restricted to cross-sectional studies. SummaryRenal MRI has seen significant recent interest and advances. Current evidence demonstrates its potential, and next steps include wider evaluation of its clinical application.3

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“…Hueper et al [18] Yu et al [15] Inci et al [14] Chandarana et al [16] Zhang et al [13] Lu et al [20] Sigmund et al [11] Wittsack et al [12] Rosenkrantz et al [54] Hueper et al [21] ASL Artz et al [26] Pedrosa et al [28] Lanzman et al [29] Rossi et al [27] Cutajar et al [23] Wu et al [24] Boss et al [22] Schor-Bardach et al [30] BOLD Park et al [37] Xiao et al [36] Min et al [38] Yin et al [34] Michaely et al [43] Xin-Long et al [33] Park et al [37] Donati et al [42] Simon-Zoula et al [32] Zhang et al…”

Section: Animal Study Dwi/ Dtimentioning

confidence: 99%

“…Rossi et al [27] performed a histogram analysis of ASL perfusion maps in patients with moderate chronic kidney disease. Significant differences in the perfusion metric of the renal cortex were found between healthy volunteers and the patients.…”

Section: Applicationsmentioning

confidence: 99%

Clinical Functional MRI of the kidneys

2013

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In functional renal magnetic resonance imaging (MRI), advanced techniques are applied to obtain information on a functional and molecular level from the kidney tissue beyond pure morphology. Techniques such as diffusion-weighted and diffusion tensor imaging, arterial spin labelling, and blood oxygenation level-dependent imaging provide potential biomarkers of organ function. Moreover, dynamic contrast-enhanced techniques after the intravenous injection of gadolinium-chelates may be used to assess glomerular filtration and urinary excretion. This review summarizes recent developments of contrast-and non-contrast-enhanced MRI techniques for assessment of renal function in a clinical setting. The physiological background and the sequence techniques are described in detail. Potential clinical applications of the different techniques are discussed regarding their potential usefulness in the assessment of parenchymal diseases, urinary tract anomalies, transplant kidney function, and renal masses.

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Histogram Analysis of Renal Arterial Spin Labeling Perfusion Data Reveals Differences Between Volunteers and Patients With Mild Chronic Kidney Disease

Cited by 64 publications

References 23 publications

Non-Contrast Renal Magnetic Resonance Imaging to Assess Perfusion and Corticomedullary Differentiation in Health and Chronic Kidney Disease

Non-Contrast Renal Magnetic Resonance Imaging to Assess Perfusion and Corticomedullary Differentiation in Health and Chronic Kidney Disease

Imaging the kidney using magnetic resonance techniques

Clinical Functional MRI of the kidneys

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