“…However, at light microscopy, no evidence of muscle fiber degeneration could be detected, thus, suggesting a neuromuscular disease as a possible pathogenetic factor in CCF. On the other hand, this hypothesis has been ruled out by several studies performed on biopsy specimens of patients with CCF, where the only recurrent microscopic finding was a relative increase of type I fibers in the musculature of the affected leg [21][22][23][24][25][26][27]. Therefore, according to Gray and Katz [22], wasting of leg musculature in CCF can only be due to a reduction in the number of muscle fibers.…”