Leg muscle atrophy in idiopathic congenital clubfoot: Is it primitive or acquired?

Ippolito, Ernesto; Maio, Fernando De; Mancini, Federico; Bellini, D.; Orefice, A.

doi:10.1007/s11832-009-0179-4

Cited by 57 publications

(66 citation statements)

References 38 publications

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“…We showed that leg muscle atrophy is a primitive defect in congenital clubfoot rather than a consequence of treatment, in agreement with previous pathologic observations in foetuses and stillborns with congenital clubfoot [2][3][4][5][6][7][8]. We also showed that leg muscle atrophy increases with the patient's age, and, therefore, a mechanism of muscle growth impairment was suggested as a possible pathogenetic factor of congenital clubfoot [1].…”

Section: Discussionsupporting

confidence: 90%

“…In a previous histologic and MRI study on UCCF [1], we measured the leg muscle surface on either histologic crosssections of foetus legs or MRI cross-scans of the legs of untreated newborns and treated children and adults. We showed that leg muscle atrophy is a primitive defect in congenital clubfoot rather than a consequence of treatment, in agreement with previous pathologic observations in foetuses and stillborns with congenital clubfoot [2][3][4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

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An MRI volumetric study for leg muscles in congenital clubfoot

Ippolito

Dragoni

Antonicoli

et al. 2012

Journal of Children's Orthopaedics

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Purpose To investigate both volume and length of the three muscle compartments of the normal and the affected leg in unilateral congenital clubfoot. Methods Volumetric magnetic resonance imaging (VMRI) of the anterior, lateral and postero-medial muscular compartments of both the normal and the clubfoot leg was obtained in three groups of seven patients each, whose mean age was, respectively, 4.8 months, 11.1 months and 4.7 years. At diagnosis, all the unilateral congenital clubfeet had a Pirani score ranging from 4.5 to 5.5 points, and all of them had been treated according to a strict Ponseti protocol. All the feet had percutaneous lengthening of the Achilles tendon. Results A mean difference in both volume and length was found between the three muscular compartments of the leg, with the muscles of the clubfoot side being thinner and shorter than those of the normal side. The distal tendon of the tibialis anterior, peroneus longus and triceps surae (Achilles tendon) were longer than normal on the clubfoot side. Conclusions Our study shows that the three muscle compartments of the clubfoot leg are thinner and shorter than normal in the patients of the three groups. The difference in the musculature volume of the postero-medial compartment between the normal and the affected side increased nine-fold from age group 2 to 3, while the difference in length increased by 20 %, thus, showing that the muscles of the postero-medial compartment tend to grow in both thickness and length much less than the muscles of the other leg compartments.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

An MRI volumetric study for leg muscles in congenital clubfoot

Ippolito

Dragoni

Antonicoli

et al. 2012

Journal of Children's Orthopaedics

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“…49 There is inconsistent evidence that the incidence of clubfoot was associated with historical seasonal outbreaks of poliomyelitis. 57 with the authors hypothesising that clubfoot may be the result of a muscle growth impairment.…”

Section: Pre-natal Influencesmentioning

confidence: 99%

“…113 Intrinsic factors such as the absence of major arteries of the foot, peripheral neuropathy and the altered histology of musculature and ligaments seen in some cases of clubfoot may contribute to the pathophysiology of relapse. [56][57][58]61,62 It is widely acknowledged that after initial correction most clubfeet in families who are noncompliant with an appropriate bracing regime will experience a structural relapse.…”

Section: Aetiology Of Relapsementioning

confidence: 99%

Interventions for congenital talipes equinovarus

Gray

Pacey

Gibbons

et al. 2010

Cochrane Database of Systematic Reviews

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“…1 The Achilles tendon acts as an invertor 2 and the calf muscles are shortened. 3 ITEV, more commonly known as clubfoot, is a disorder affecting one or both lower limbs with fifty percent of cases being bilateral.…”

mentioning

confidence: 99%

A Literature Review of Non-Surgical Intervention for the Treatment of Idiopathic Talipes Equinovarus: A Podiatric Perspective

McGroggan¹,

Dunlop²

2010

FAOJ

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The scans were observed at 18-23 weeks of foetal gestation with occurrence being bilateral in 64 cases and unilateral in 43. The researchers reported 51.4% of these cases were idiopathic and 48.6% were associated with other pathologies. 6 Idiopathic talipes equinovarus has a familial link and displays clear racial prevalence 7 however, the reason for the abnormal development is still unkown. 4 In third world countries ITEV is frequently left untreated and affected people will suffer diminished mobility, ulcerations from abnormal weight bearing and be socially ostracised. In the United Kingdom (UK) ITEV has historically been treated primarily through orthopaedic surgery until around 2003 when non surgical methods became more widely available.

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Leg muscle atrophy in idiopathic congenital clubfoot: Is it primitive or acquired?

Abstract: To investigate whether atrophy of the leg muscles present in congenital clubfoot (CCF) is primitive or secondary to treatment of the deformity

Cited by 57 publications

References 38 publications

An MRI volumetric study for leg muscles in congenital clubfoot

An MRI volumetric study for leg muscles in congenital clubfoot

Interventions for congenital talipes equinovarus

A Literature Review of Non-Surgical Intervention for the Treatment of Idiopathic Talipes Equinovarus: A Podiatric Perspective

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