Histochemistry of Hidradenoma and Eccrine Spiradenoma

Winkelmann, R. K.; Wolff, Klaus

doi:10.1038/jid.1967.121

Cited by 36 publications

(25 citation statements)

References 19 publications

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“…Although decapitation secretion has been observed in the luminar structures of the tumor, 1 none of the NH has been shown to have enzymes that would indicate an apocrine differentiation. In contrast, the presence of eccrine‐type enzymes, ie, amylophosphorylase, branching enzyme, succinic dehydrogenase, diphosphopyridine nucleotide diaphorase, and leukine aminopeptidase suggests a tumor of eccrine differentiation 19 . This has been supported by the finding of eccrine‐specific ultrastructural features such as an intercellular canalicular system and intracellular organelles that closely resemble those of eccrine secretory cells 20 .…”

Section: Discussionmentioning

confidence: 97%

Nodular Hidradenoma

Stratigos

Olbricht²,

Kwan³

et al. 1998

Dermatologic Surgery

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Section: Discussionmentioning

confidence: 97%

Nodular Hidradenoma

Stratigos

Olbricht²,

Kwan³

et al. 1998

Dermatologic Surgery

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“…With 34PE12 (against CKs 1,5,10,and 14), LP54 (against CKs 5, 6, and 18), and MNF116 (against Fig. 4.…”

Section: The Periluminai Cells In the L And S Nestsmentioning

confidence: 99%

“…4. Immunohislochemical staining with antibody 34PE12 (against CKs 1,5,10,and 14). In tlie M nests, nearly att tumor cells reveal a po.sitive staining (original magnification, x33).…”

Section: The Periluminai Cells In the L And S Nestsmentioning

confidence: 99%

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Histogenesis of clear cell hidradenoma: immunohistochemical study of keratin expression

Ohnishi

Watanabe

1997

J Cutan Pathol

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The expression of cytokeratins in 10 cases of clear cell hidradenoma, including 3 cases of solid cystic hidradenoma, were examined using 21 kinds of monoclonal antibodies. We divided them into three histologic patterns: massive nests with a few lumina (M nests), nests with some tubular lumina (L nests), and nests in solid cystic hidradenomas (S nests). All hidradenomas showed similar immunoreactivities to those in the lower dermal ducts or secretory cells of normal eccrine glands. With antibodies against simple epithelial cytokeratins (CKs 7, 8, 18, and 19), however, different immunostaining was noted among the three histologic patterns. Namely, the M nests failed to react to them, although some luminal cells in the L nests revealed a positive staining. Furthermore, a majority of luminal cells in the S nests revealed a positive staining with them. Therefore, we think that the luminal cells in solid cystic hidradenoma mainly differentiate toward the secretory cells, and that the M nests mainly differentiate toward the dermal duct. Those in the L nests are thought to differentiate toward the dermal duct and the secretory cells. The proportion of the differentiation toward luminal cells of dermal ducts to the differentiation toward secretory cells was the main difference among the three nests. In addition, there was no difference in immunophenotypes between clear cells and epidermoid cells in the two kinds of hidradenomas.

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“…(10) DISCUSSION: Nodular hidradenoma is also known as clear cell myoepithelioma,clear cell hidradenoma,eccrine sweat gland adenoma of clear cell type, solid cystic hidradenoma and eccrine acrospiroma. (11) Nodular hidradenoma are conventionally regarded as eccrine sweat gland neoplasm but apocrine differentiation can also occur. Enzyme histochemical and electron microscopical features show eccrine differentiation.…”

Section: Introductionmentioning

confidence: 99%

Study on Morphological Features of Nodular Hidradenoma

Thippeswamy¹,

Duraisamy²,

Gayathri³

2015

jemds

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Study conducted in Government Villupuram medical college about morphological features of nodular hidradenoma by reviewing the hispathology slides of five cases in one year period. Analytical study done regarding the gender, age, and sites distribution of tumour and also variation in gross and histopatholgy features. OBJECTIVE: To describe and study the morphological features of Nodular Hidradenoma along with data on gender and age. Study on Sites and morphological features also included. MATERIALS AND METHOD: Retrospective evaluation of histopathological records during the previous year 2013-2014. The study was conducted in Tertiary care Teaching hospital, Government Villupuram Medical College, Villupuram. 5 cases of nodular hidradenoma were identified. Data on gender, age, Clinical presentation, gross and microscopic findings with hematoxylin and eosin stains were collected. Histological slides were reviewed. KEYWORDS: Giant Nodular hidradenoma, Cyst with papillary excrescencess, Squamous horn pearls, solid and cystic areas. INTRODUCTION:Nodular hidradenoma is a benign adnexal neoplasm arising from the distal excretory ducts of eccrine sweat glands. Though it is a benign neoplasm very rarely malignant transformation can occur. (1) It frequently occurs from fourth to eighth decade of life and it is rare in children. (1) This tumor has gender predilection with female preponderance in ratio of 1.7:1. (2) It most commonly occurs in head, trunk and extremities and can occur in any cutaneous skin surface. (3) Our case series includes one case in breast. These tumours usually presents as a solitary, slowly enlarging, intradermal nodule, ranging in size from 0.5-2.0cm or more. Nodular hidradenoma breast is still a rare tumour. (4) Rapid enlargement of the tumor raises the possibility of malignant transformation or haemorrhage. (5) Grossly these tumors are often solid and cystic. (6) Microscopically, they are well circumscribed , sharply demarcated from the epidermis by Grenz zone and tumor is composed of solid and cystic spaces. Solid areas reveal the presence of epithelial lobules. Within the lobules two types of cells are seen. Predominant cell type is the polyhedral cells with more basophilic cytoplasm and the other cell type is round with a clear cytoplasm due to the presence of glycogen. (7) Cystic spaces often contain eosinophilic fluid material, these cysts occur due to tumor cell degeneration. Lumen of cysts usually contain homogenous eosinophilic material and in few cases contain haemorrhagic foci probably due to rapid growth of lesion or after minor trauma. (8) There are also tubular lumina of varying sizes seen, sometimes lined by cuboidal ductal cells. In some tumors squamoid differentiation (9) can occur. There even may be keratinizing cells with formation of squamous horn pearls particularly in clear cell hidradenoma. (10)

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Histochemistry of Hidradenoma and Eccrine Spiradenoma

Cited by 36 publications

References 19 publications

Nodular Hidradenoma

Nodular Hidradenoma

Histogenesis of clear cell hidradenoma: immunohistochemical study of keratin expression

Study on Morphological Features of Nodular Hidradenoma

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