Nodular Hidradenoma

Abstract

This report highlights the salient histologic findings that distinguish nodular hidradenomas from other adnexal tumors and emphasizes the benefit of complete local excision to prevent recurrence of these tumors.

Dermoscopy of Nodular Hidradenoma, a Great Masquerader: A Morphological Study of 28 Cases

“…Nodular hidradenoma (NH), also termed clear cell hidradenoma, solid-cystic hidradenoma and eccrine acrospiroma, is an uncommon, benign, adnexal neoplasm which is currently thought to be of apocrine origin [1,2]. The classic histopathologic presentation of NH is characterised by a circumscribed but unencapsulated tumour composed of lobulated, sometimes cystic masses of cells mainly located in the upper or mid dermis but occasionally extending deep into the subcutaneous tissue.…”

“…NH is found most often in middle-aged adults or the elderly, with a slight predominance in females. It is more common on the head and neck or trunk [1,2]. NH lacks any distinctive clinical attributes but is usually present as a solitary, asymptomatic, well-circumscribed, slowly growing, nodular, cystic or pedunculated lesion measuring in most cases between 0.5 and 3 cm in diameter.…”

“…Some tumours may spontaneously drain serous or haemorrhagic material [1,2]. Due to its variable and non-specific clinical presentation it might be difficult to make a correct diagnosis of this tumour, and its differential diagnosis includes various adnexal tumours, epidermal cysts, cutaneous metastases, basal cell carcinoma and melanoma [1,2]. Dermoscopy is a non-invasive technique which has greatly improved the diagnostic accuracy of pigmented and non-pigmented skin tumours.…”

“…Duct-like structures are present in most tumours, and commonly, the neoplasm contains variably sized cystic cavities. The stroma of NH is commonly sclerotic and may contain ectatic vessels [1,2]. NH is found most often in middle-aged adults or the elderly, with a slight predominance in females.…”

“…The overlying skin may be smooth, thickened, atrophic or ulcerated, and may have a skin-coloured, red, brown or blue appearance. Some tumours may spontaneously drain serous or haemorrhagic material [1,2]. Due to its variable and non-specific clinical presentation it might be difficult to make a correct diagnosis of this tumour, and its differential diagnosis includes various adnexal tumours, epidermal cysts, cutaneous metastases, basal cell carcinoma and melanoma [1,2].…”