Histochemistry and Development of the Human Eyelids Ii

Andersen, Hans Thor; Ehlers, Niels; Me, Matthiessen; Mh, Claësson

doi:10.1111/j.1755-3768.1967.tb06492.x

Cited by 30 publications

(7 citation statements)

References 3 publications

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“…It was postulated that the keratinization process of the intermediate cell layer softens the cells in the junctional layer 14 , 16 , 45 , 46 . Other studies revealed that the keratinization is only second in order of importance to holocrine production of lipids from the developing meibomian glands 12 , 14 , and that the final stage of disjunction is attributed to traction by eyelid muscles 14 . Recently, these old concepts have been modified 11 .…”

Section: Milestones In Fetal Development Of the Eyelid And The Lacrimal Drainage Systemmentioning

confidence: 99%

“…The eyelid begins to form during the 6th week and continues to develop until nearly complete at the 36th week. The three temporal features of eyelid development in humans are eyelid growth, eyelid differentiation, and eyelid maturation 14 .…”

Section: Eyelid Morphogenesis – a Dynamic Process Of Complex Interact...mentioning

confidence: 99%

“…The exact timing of the development of the lacrimal caruncle is not thoroughly clear. In the literature, it is considered to develop “soon” after eyelid fusion 14 . It should be noted that it is not formed from the conjunctiva but as an offshoot from the lower eyelid.…”

Section: Milestones In Fetal Development Of the Eyelid And The Lacrim...mentioning

confidence: 99%

“…If this were true, obstetricians would have reported isolated ankyloblepharon filiforme adnatum more often. Histologic sections reveal that eyelids start to separate nasally and anteriorly, then extend temporally and posteriorly by gradual sloughing of periderm cells into the amniotic fluid 11 , 14 , 16 . Until recently, eyelid separation remained unclear.…”

Section: Milestones In Fetal Development Of the Eyelid And The Lacrim...mentioning

confidence: 99%

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Embryologic and Fetal Development of the Eyelid and the Lacrimal Drainage System

Gaca

Lewandowicz

Lipczyńska-Lewandowska

et al. 2022

Klin Monbl Augenheilkd

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The embryological and fetal morphogenesis of the eyelids and lacrimal drainage system is multifactorial and complex. This protracted process begins in the 5th week of prenatal life and involves a successive series of subtle and tightly regulated morphogenetic events. Major milestones of the embryological and fetal development of the eyelids include the beginning of eyelid formation during the 6th week, eyelid fusion by the 8th week, and the development of eyelid structures beginning in the 9th week (immediately following eyelid fusion), with progression until eyelid separation by the 24th week. After eyelid separation, the eyelids begin to assume their newly developed shape. Around the 32nd week, eyelids are almost fully developed and fully separated but still visibly closed. Key development steps of the lacrimal drainage system include formation of the lacrimal lamina (the primordium of the future lacrimal system) and the lacrimal cord (the primordium of the lacrimal canaliculi) in the 7th week, with canalization starting from the 10th week. During the 10th week, the excretory lacrimal system displays a lumen with a true lacrimal duct that can be distinguished. The epithelium of the lacrimal canaliculi is in contact with the palpebral conjunctival epithelium. The two epithelia form a continuous epithelial lamina. The caudal extreme of the lacrimal duct and the inferior meatal lamina join and the latter begins to cavitate. Understanding this multidimensional process of development in prenatal life, as well as identifying and linking signaling cascades and regulatory genes to existing diseases, may pave the way for developing minimally invasive interventions and scar reducing surgical methods, controlling the spread of malignancies, and the use of progenitor/stem cell and even regenerative therapy.

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Section: Milestones In Fetal Development Of the Eyelid And The Lacrimal Drainage Systemmentioning

confidence: 99%

Section: Eyelid Morphogenesis – a Dynamic Process Of Complex Interact...mentioning

confidence: 99%

Section: Milestones In Fetal Development Of the Eyelid And The Lacrim...mentioning

confidence: 99%

Section: Milestones In Fetal Development Of the Eyelid And The Lacrim...mentioning

confidence: 99%

See 2 more Smart Citations

Embryologic and Fetal Development of the Eyelid and the Lacrimal Drainage System

Gaca

Lewandowicz

Lipczyńska-Lewandowska

et al. 2022

Klin Monbl Augenheilkd

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“…Before the junction a very thick "basement membrane" is seen by light-microscopy beneath the junctional epithelium. By electron-microscopy the thick "membrane" is seen as a condensation of collagen and precollagen fibres close to the epithelial basement membrane ( Andersen et al 1965Andersen et al , 1967. Normally the eyelids reopen in the 6th to 7th foetal month.…”

Section: Commentsmentioning

confidence: 99%

Ankyloblepharon Filiforme Congenitum Associated With Harelip and Cleft‐palate

Ehlers

Jensen

1970

Acta Ophthalmologica

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Ankyloblepharon filiforme congenitum (or adnatum) indicates a malformation in which the margins of the upper and lower eyelids are connected by extensile tissue bands. In the literature 24 cases have been reported.Lohlein (1930) showed a photograph of a baby with ankyloblepharon filiforme and an obvious cleft-lip. Later this coincidence of malformations have been reported by Khanna (1957) and by Long & Blandford (1962). V a n der W o u d e (1954) described a family with a strong occurrence of labial fistula, cleft-lip and cleft-palate, in which one of the patients with labial fistula had unilateral ankyloblepharon filiforme. The present case brings the number of the coincidence of ankyloblepharon and harelip and/or cleft-palate up to 5 out of a total of 24 cases of ankyloblepharon filiforme.A total ankyloblepharon in most cases occurs associated with severe facial and ocular malformations. Berndorfer (1965) in a report of four cases with gross defects of the facial structures presented one with complete cleft-lip and cleft-palate associated with homolateral, total ankyloblepharon and microphthalmos.

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?9 and ?8 integrin expression correlates with the merger of the developing mouse eyelids

Stepp

1999

Dev. Dyn.

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Histochemistry and Development of the Human Eyelids Ii

Cited by 30 publications

References 3 publications

Embryologic and Fetal Development of the Eyelid and the Lacrimal Drainage System

Embryologic and Fetal Development of the Eyelid and the Lacrimal Drainage System

Ankyloblepharon Filiforme Congenitum Associated With Harelip and Cleft‐palate

?9 and ?8 integrin expression correlates with the merger of the developing mouse eyelids

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