Histochemical and ultrastructural changes in senile human skeletal muscle

Tomonaga, Masanori

doi:10.1097/00006534-197709000-00125

Cited by 51 publications

(73 citation statements)

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“…The results of the present investigation suggest that in humans, satellite cell proportions do not differ significantly among healthy, sedentary young and older men and women. Of the myonuclear variables quantitatively assessed in the present study, only the number of central myonuclei was significantly different in the older individuals, a finding similar to previous reports (Scelsi, 1980;Tomonaga, 1977).…”

Section: Discussionsupporting

confidence: 92%

“…Investigations of older human skeletal muscle have revealed several changes in muscle fiber morphology, however there has been only limited discussion of satellite cell morphology (Shafiq, 1978;Tomonaga, 1977). Shafiq et al (1978) reported the presence of lipofuscin granules in muscle fibers and occasionally in satellite cells and Tomonaga (1977) observed satellite cells of a "dense appearance" in older subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Shafiq et al (1978) reported the presence of lipofuscin granules in muscle fibers and occasionally in satellite cells and Tomonaga (1977) observed satellite cells of a "dense appearance" in older subjects. Schultz (1976) reported several morphological changes in satellite cell morphology with increasing age in mice, including fewer ribosomes, reduced areas of ER and golgi, and a higher proportion of heterochromatin.…”

Section: Discussionmentioning

confidence: 99%

“…Possible changes in satellite cell characteristics in older human skeletal muscle are unclear and studies that have been completed are associated with limitations in scope and methodology (Shafiq, 1978;Tomonaga, 1977). Schmalbruch and Hellhammer (1976) reported a lower satellite cell proportion (0.6%) in a 73-year-old male compared to satellite cell proportions (Ϸ4%) in eight adults between 20 and 34 years of age, however, no other older subjects were assessed in that investigation.…”

mentioning

confidence: 97%

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Skeletal muscle satellite cell populations in healthy young and older men and women

et al. 2000

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

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Skeletal muscle satellite cell populations in healthy young and older men and women

et al. 2000

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“…The most frequent morphological manifestations are type II atrophy, small angulated fibres and fibre grouping (Tomonaga 1977).…”

Section: Introductionmentioning

confidence: 99%

Glycosylation pattern and enzyme activities in atrophic, angulated skeletal muscle fibres from ageing rats

Kirkeby

1994

Vichows Archiv A Pathol Anat

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In this study enzyme activities and lectin binding patterns in skeletal muscle from very old rats were investigated in order to evaluate changes in enzyme activity or carbohydrate expression in senile muscle. Activities for adenosine triphosphatase (ATPase), succinic dehydrogenase, non-specific esterase and the binding pattern for 31 lectins were investigated in the soleus muscles from very old (36 months) and young (3 months) rats. In ageing muscles atrophic, angulated muscle fibres are frequent. In cryostat sections these fibres were mostly but not always type II defined by the myosin ATPase reaction; few showed a strong esterase activity. Some showed strong activity for succinic dehydrogenase while others were weakly reacting. A number of lectins strongly bound to the sarcoplasm in angulated fibres while the binding to normal fibres in both old and young rat muscle was much weaker or even absent. Preferential binding to the ageing, angulated fibres was seen with Aleuria aurentia, Galantus nivalis, Caragana abborecens, Triticum vulgaris, Maackia amurensis, Sambucus nigra, Phaseolus vulgaris erythroagglutinin, and Phaseolus coccineus. Samples of homogenized and centrifuged muscles were run by electrophoresis and the gels blotted to nitrocellulose paper. Subsequent lectin staining of the blots detected that two glycoproteins with molecular weights around 25,000 and 21,000 daltons were present in old muscle, but not in young. Aberrant or elevated expression of sarcoplasmic glycoconjugates is involved in ageing muscle atrophy.

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Maximal voluntary isometric force production characteristics of six muscle groups in women aged 25 to 74 years

Christ

Boileau

Slaughter

et al. 1992

American J Hum Biol

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The age-related force production characteristics of six muscle groups in 143 women aged 25-74 years were examined. Measures of maximal force (MFR) were obtained on the finger flexors (FF), thumb extensors (TE), forearm flexors (FAF), forearm extensors (FAE), dorsi flexors (DF), and plantar flexors (PF) utilizing a linear voltage differential transducer. The subjects were categorized by age into ten 5-year groups. The magnitude of decline across age in MFR ranged from 36.2% IFAE) to 45.1% (PF). There were differences among muscle groups in the age at which a significant decline in MFR was first detected. The earliest drop off in MFR was observed in FF and FAF (45-49 years), while the latest significant decline across age was noted in FAE (65-69 years). Since the magnitude of maximal force decreases with age, and because these charactemtics can not be entirely explained by age-related decrements in €at-free mass, it appears that the quality in addition to the quantity of senescent muscle tissue may be compromised. However, the magnitude of decline in maximal force is dependent upon the muscle group considered.

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Histochemical and ultrastructural changes in senile human skeletal muscle

Cited by 51 publications

References 0 publications

Skeletal muscle satellite cell populations in healthy young and older men and women

Skeletal muscle satellite cell populations in healthy young and older men and women

Glycosylation pattern and enzyme activities in atrophic, angulated skeletal muscle fibres from ageing rats

Maximal voluntary isometric force production characteristics of six muscle groups in women aged 25 to 74 years

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