Histiocytoid and signet-ring cell carcinoma of the axilla: a type of cutaneous apocrine carcinoma equivalent to histiocytoid lobular carcinoma of the breast?

Misago, Noriyuki; Shinoda, Yohsuke; Okawa, Takeshi; Aoki, Shigehisa; Toda, Shogo; Koike, Kazuo; Narisawa, Yutaka

doi:10.1111/j.1365-2230.2011.04106.x

Cited by 18 publications

(52 citation statements)

References 10 publications

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“…Moreover, overexpression of HER2 indicates poor prognosis with shortened disease‐free and overall survival in breast cancer. PSRCHC of the eyelid has usually been negative for HER2 expression, 1 while PSRCHC of the axilla has been positive 3 . In our case, HER2 protein was overexpressed, but the gene was not amplified.…”

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confidence: 50%

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Primary signet‐ring cell/histiocytoid carcinoma of the axilla expressing human epidermal growth factor receptor 2

Miyake¹,

Sugiu²,

Hamada³

et al. 2012

The Journal of Dermatology

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confidence: 50%

“…Misago et al. 3 suggested that axillary PSRCHC would be a type of cutaneous apocrine carcinoma, which is equivalent to histiocytoid lobular carcinoma of the breast.…”

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confidence: 99%

Primary signet‐ring cell/histiocytoid carcinoma of the axilla expressing human epidermal growth factor receptor 2

Miyake¹,

Sugiu²,

Hamada³

et al. 2012

The Journal of Dermatology

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“…In patients that present with positive regional lymph nodes, lymphadectomy, in addition to the removal of the primary, is common treatment among the PCAC literature [2,3,15,[20][21][22][23]. Radiotherapy may also provide additional benefit among those with regional lymph node metastases; however data is limited.…”

Section: Discussionmentioning

confidence: 99%

Treatment of primary cutaneous apocrine carcinoma of the scalp - case and review of the literature

Brown¹,

Riesco-Martinez²,

Petrella³

2016

Glob Dermatol

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A previously healthy 42 year-old woman presented at her family doctor after her hairdresser noticed a nodule in the left temporo-parietal area of the scalp. The mass was a firm, reddish nodule measuring approximately 3 × 2 cm. The patient was completely asymptomatic. She was referred to dermatology, and the lesion was excised. The initial pathology report showed a moderately-well differentiated adenocarcinoma. It was unclear at this time whether this was a primary lesion of the sweat gland or metastatic adenocarcinoma from another site. She was then referred to our centre for oncologic work-up.The pathology was reviewed and confirmed a moderately differentiated adenocarcinoma (Figure 1). The tumour was formed by single tubules or complex back to back tubular structures with areas where the luminal cells showed apical snouts. The lesion filled the reticular dermis without involving the epidermis. No perineural or lymphovascular invasion was present. The resection margins were clear, with the closest margin at 2 mm. The immunohistochemistry showed positivity for CK 7, ER, PR, Androgen receptor, CDX2, Ber ep4 and EMA. It was found to be negative for High molecular weight keratin, CK 20, COX2, CDX2, TTF1, Renal cell marker, CD 117, and CEA. It was concluded that this profile was most consistent with a metastatic breast carcinoma; however an eccrine/apocrine carcinoma of the skin could not be completely ruled out.On physical examination, there was no palpable lymphadenopathy of the neck, supraclavicular or infraclavicular regions bilaterally. No pre-or postauricular lymphadenopathy. On the left temporal parietal scalp, there was a 3 cm, well-healed scar, with no signs of infection or IntroductionPrimary cutaneous apocrine carcinoma (PCAC) is a rare type of sweat gland neoplasm with incidence rates estimated to range from 0.0049-0.0173 per 100,000 patients per year [1]. Approximately 200 total cases are reported in the literature. PCAC occurs in areas with large numbers of apocrine glands [2]. The scalp is among one of the rarest sites of occurrence, while the axilla appears most commonly [3]. Among the 186 cases reviewed by Hollowell, equal distribution was present in both males and females, with 76% of the sample population of Caucasian ethnicity. Median age was calculated at 67 years for this sample, which is the largest cohort studied to date [1].PCAC can develop in the dermal and subcutaneous layers of the skin, occasionally infiltrating the epidermal layer resulting in ulceration. PCAC has a diverse presentation, occurring as both uniand multi-nodular growths with varying colour [2]. Often these neoplasms are indurated, painless masses and can be associated with benign lesions [2], including a nevus sebaceous, most commonly seen with scalp lesions [4][5][6]. Development of these lesions typically occurs within a year before diagnosis [7]; however several cases have reported longer durations with a period of rapid growth [4,5,8,9]. PCAC is often quite difficult to differentiate from metastases of adenocarcinoma o...

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“…Primary signet‐ring cell/histiocytoid carcinoma has been described in few scattered case reports in the literature. About 20 cases have been reported involving the eyelid and only five cases have been reported previously involving the axilla . Whether this neoplasm is of apocrine or eccrine origin has remained a source of debate .…”

Section: Discussionmentioning

confidence: 99%

“…Primary signet‐ring cell/histiocytoid carcinoma (hereafter, cutaneous signet‐ring cell carcinoma) represents an extremely rare adnexal neoplasm that most frequently not only presents on the eyelid but has also been reported to present within the axilla . Because of its histopathologic similarity to lobular carcinoma of the breast as well as other metastatic carcinomas with signet‐ring cells such as signet‐ring cell adenocarcinoma of the stomach, lung or prostate, a comprehensive workup for other primary sources of carcinoma is often required prior to definitive diagnosis of cutaneous signet‐ring cell carcinoma …”

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Primary signet‐ring cell carcinoma of the axilla

et al. 2012

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Primary cutaneous histiocytoid or signet-ring cell carcinoma represents an extremely rare adnexal neoplasm that most frequently presents on the eyelid but more rarely may present in the axilla. As this tumor can resemble metastatic carcinoma with signet-ring cells, especially lobular carcinoma of the breast, it can often present a diagnostic challenge. We present a case of cutaneous signet-ring cell carcinoma presenting in the axilla and outline the challenges of diagnosing this rare malignancy.

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Histiocytoid and signet-ring cell carcinoma of the axilla: a type of cutaneous apocrine carcinoma equivalent to histiocytoid lobular carcinoma of the breast?

Cited by 18 publications

References 10 publications

Primary signet‐ring cell/histiocytoid carcinoma of the axilla expressing human epidermal growth factor receptor 2

Primary signet‐ring cell/histiocytoid carcinoma of the axilla expressing human epidermal growth factor receptor 2

Treatment of primary cutaneous apocrine carcinoma of the scalp - case and review of the literature

Primary signet‐ring cell carcinoma of the axilla

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