Primary signet‐ring cell/histiocytoid carcinoma of the axilla expressing human epidermal growth factor receptor 2

Miyake, Tomoko; Sugiu, Maho; Hamada, Takeshi; Otsuka, Masaki; Yanai, Hiroyuki; Morishita, Yoshiko; Iwatsuki, Keiji

doi:10.1111/j.1346-8138.2012.01561.x

Cited by 8 publications

(14 citation statements)

References 3 publications

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“…The behavior of the patient's tumor is similar to that of metastatic breast cancer, providing support to previous authors’ suggestions that this entity is equivalent to histiocytoid lobular carcinoma of the breast . Interestingly, cases of primary cutaneous histiocytoid carcinoma of the axilla have often been Her 2‐neu positive, in contrast to other primary apocrine carcinoma tumors . This has important implications for management, as the anti‐Her 2‐neu antibody, trastuzumab, may be an effective therapy .…”

Section: Discussionsupporting

confidence: 70%

“…6 Interestingly, cases of primary cutaneous histiocytoid carcinoma of the axilla have often been Her 2-neu positive, in contrast to other primary apocrine carcinoma tumors. 3,6,14,15 This has important implications for management, as the anti-Her 2neu antibody, trastuzumab, may be an effective therapy. 6,15 Continued study of these challenging tumors is needed.…”

Section: Most Cases Have Occurred In Middle-aged or Elderly Malesmentioning

confidence: 99%

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Primary cutaneous histiocytoid carcinoma with distant metastasis

et al. 2017

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Distinguishing primary cutaneous adnexal carcinoma from metastatic carcinoma of unknown primary can be a diagnostic challenge due to the frequent overlap of histologic and immunohistochemical features. A 58-year-old man presented with a tender, indurated plaque on axillary skin. Biopsy revealed infiltrating atypical cells throughout the dermis, without connection to the epidermis. Tumor cells had a histiocytoid appearance and displayed mild pleomorphism. The tumor was discohesive and had areas with a single file pattern. Signet ring cells were also present. Cells were reactive with CK7, CK5/6, p63, GATA3, GCDFP-15 and Her 2-neu. Additional studies were negative, including TTF-1, CDX2, E-cadherin, mammaglobin, estrogen receptor and progesterone receptor. Thorough clinical and radiologic evaluation failed to identify an occult primary extracutaneous malignancy; however, regional lymphadenopathy, widespread osteoblastic lesions and multiple subcentimeter liver hypodensities were noted. Considering the clinical and histopathologic features, the diagnosis of primary cutaneous histiocytoid carcinoma with distant metastasis was favored.

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Section: Discussionsupporting

confidence: 70%

Section: Most Cases Have Occurred In Middle-aged or Elderly Malesmentioning

confidence: 99%

Primary cutaneous histiocytoid carcinoma with distant metastasis

et al. 2017

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“…Immunophenotypically, the cells show reactivity for a subset of cytokeratins (CAM 5.2, CK7, AE1/3 and MNF116) as well as CEA, GCDFP‐15, lysozyme, CD15, epithelial membrane antigen and, in some cases, S100 protein . Other markers like CK20, p63, HER2, ER and PR are positive in some reports but negative in others . Negative ER and PR staining may be helpful in differentiating this neoplasm from breast carcinoma .…”

Section: Discussionmentioning

confidence: 99%

Primary signet‐ring cell carcinoma of the axilla

et al. 2012

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Primary cutaneous histiocytoid or signet-ring cell carcinoma represents an extremely rare adnexal neoplasm that most frequently presents on the eyelid but more rarely may present in the axilla. As this tumor can resemble metastatic carcinoma with signet-ring cells, especially lobular carcinoma of the breast, it can often present a diagnostic challenge. We present a case of cutaneous signet-ring cell carcinoma presenting in the axilla and outline the challenges of diagnosing this rare malignancy.

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“…2 To the best of our knowledge, only nine cases of PSRCHC occurring in the axilla have been reported. [3][4][5][6][7][8][9] Herein, we report a case of axillary PSRCHC with chromogranin A expression, and discuss its clinicopathological features and histogenesis.…”

Section: Of the Axillamentioning

confidence: 97%

“…2 Immunohistochemical features of PSRCHC of the axilla and eyelid are summarized in Table 1. [2][3][4][5][6] With regard to the biological behavior of axillary PSRCHC, this type of carcinoma shows a high rate of lymph node metastases because 6 of 10 cases had axillary or sentinel lymph node metastases. Despite this, none of these cases resulted in death due to this disease (two patients died of unrelated cause).…”

Section: Of the Axillamentioning

confidence: 99%