Histiocytic Sarcoma : An Updated Literature Review Based on the 2008 WHO Classification

Takahashi, Emiko; Nakamura, Shigeo

doi:10.3960/jslrt.53.1

Cited by 174 publications

(298 citation statements)

References 44 publications

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“…The nuclei show atypia and are generally large, round to oval, irregularly folded and eccentrically placed [1,12]. Our case had similar histological findings.…”

Section: Discussionsupporting

confidence: 70%

“…It is also known as true histocytic lymphoma, malignant histiocytosis, histocytic medullary reticulosis, reticulum sarcoma and regressing atypical histocytosis [1,11,12].…”

Section: Discussionmentioning

confidence: 99%

“…There is wide age variation from infancy to adults, with male predilection [1]. It commonly involves lymph node, however can occur at extranodal sites like gastrointestinal tract, spleen, soft tissue, skin, head and neck region, salivary gland, lung, mediastinum, breast, liver, pancreas, kidney, uterus, central nervous system, skeletal system and bone marrow [1,12].…”

Section: Discussionmentioning

confidence: 99%

“…Morphologically, HS comprises of diffuse, non-cohesive proliferation of large cells [1,12]. The nuclei show atypia and are generally large, round to oval, irregularly folded and eccentrically placed [1,12].…”

Section: Discussionmentioning

confidence: 99%

“…Histiocytic sarcoma (HS) is a neoplasm derived from mononuclear phagocytes or histiocytes, which have major role in processing and presenting antigens to T or B lymphocytes [1]. HS is a rare hematopoietic neoplasm constituting less than 1 % of the haematolymphoid neoplasm [2].…”

Section: Introductionmentioning

confidence: 99%

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Histiocytic Sarcoma with Acute Lymphoblastic Leukemia a Rare Association: Case Report and Literature Review

Ganapule

Gupta

Kokil

et al. 2014

Indian J Hematol Blood Transfus

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Definition and diagnostic criteria for histiocytic sarcoma (HS) have changed over last two decades due to available new immunohistochemical markers, as well as better understanding of the biology of disease. We report here a case of 4 years old boy diagnosed as acute lymphoblastic leukemia (ALL), who later developed HS of pleura, when he was on maintenance phase of ALL protocol. HS constitutes less than 1 % of the haematolymphoid neoplasm, even more rare is association of HS with ALL. Thus reporting here a rare association of HS with ALL, will help in knowing the actual incidence of HS as well as association with ALL.

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“…The nuclei show atypia and are generally large, round to oval, irregularly folded and eccentrically placed [1,12]. Our case had similar histological findings.…”

Section: Discussionsupporting

confidence: 70%

“…It is also known as true histocytic lymphoma, malignant histiocytosis, histocytic medullary reticulosis, reticulum sarcoma and regressing atypical histocytosis [1,11,12].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Histiocytic Sarcoma with Acute Lymphoblastic Leukemia a Rare Association: Case Report and Literature Review

Ganapule

Gupta

Kokil

et al. 2014

Indian J Hematol Blood Transfus

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Orbital Apex Syndrome in a Patient With Histiocytic Sarcoma

2019

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A man in his early 20s presented with a headache for 3 weeks and right ptosis and diplopia for 1 week as well as loss of vision in the right eye for 2 days. Neurological examination revealed an orbital apex syndrome including impairment of the right II, III, IV, V1, and VI cranial nerves. No significant personal or family history was present. Blood tests showed that his white blood cell count, erythrocyte sedimentation rate, C-reactive protein level, and procalcitonin level were all in normal ranges. Results of the serum galactomannan test and glucan test were negative. Lumbar puncture showed a normal white blood cell count, glucose level, and protein content in the cerebrospinal fluid. Results of india ink staining for Cryptococcus and Gram staining for bacteria in his cerebrospinal fluid were negative. Magnetic resonance imaging revealed a 2.4 × 2.8 × 3.6-cm mass lesion in the right ethmoid sinus and sphenoid sinus, with bone destruction of the inner wall of right orbit and involvement of the right medial rectus muscle and right optic nerve. The mass appeared isointense and hyperintense to muscle on T1-weighted and T2-weighted images, with heterogeneous enhancement on postcontrast T1-weighted images (Figure 1). Surgical removal of the mass was performed.Microscopically, the lesion was composed of atypical tumor cells with oval nucleus, small nucleolus, eosinophilic cytoplasm, and scattered mitotic figures. Immunohistochemical stainings showed the tumor cells were positive for vimentin,

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