Histiocytic necrotizing lymphadenitis preceding systemic lupus erythematosus

Komócsi, András; E, Tóvári; Pajor, László; Czirják, László

doi:10.1046/j.1468-3083.2001.00310.x

Cited by 13 publications

(4 citation statements)

References 24 publications

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“…13,14 Some patients who had recurrent HNL did not show any skin lesions when they were first diagnosed with HNL. 15,16 However, when these patients were diagnosed with SLE, diverse skin lesions developed during the second episode of HNL, coexisting with SLE. These patients are similar to the presented case 9.…”

Section: Discussionmentioning

confidence: 99%

Histiocytic necrotizing lymphadenitis in the context of systemic lupus erythematosus (SLE): Is histiocytic necrotizing lymphadenitis in SLE associated with skin lesions?

Kim

Kang

Yoon

et al. 2011

Lupus

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Histiocytic necrotizing lymphadenitis (HNL), or Kikuchi's disease, is a benign and self-limiting lymphadenopathy that typically affects young Asian females. It presents with lymphadenopathy, usually cervical, accompanied by fever, chills and leukopenia. Although the association between systemic lupus erythematosus (SLE) and HNL is rare, the number of reports of HNL in SLE patients is increasing. We present nine cases of HNL in patients with SLE. Among the seven patients with diverse skin manifestations, three had skin manifestations that were histologically compatible with SLE. A review of previous reports in the literature showed that cutaneous involvement was commonly found in HNL in association with SLE. In the patients who had simultaneous onset of both diseases, lupus flare-ups were commonly observed. We suggest that HNL in SLE patients is associated with cutaneous manifestations. This report contributes to our understanding of the relationship between these diseases.

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Section: Discussionmentioning

confidence: 99%

Histiocytic necrotizing lymphadenitis in the context of systemic lupus erythematosus (SLE): Is histiocytic necrotizing lymphadenitis in SLE associated with skin lesions?

Kim

Kang

Yoon

et al. 2011

Lupus

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“…In reporting a new case of nodal and cutaneous KD, we reviewed the literature in order to seek reliable criteria for its differential diagnosis. To the best of our knowledge, 27 cases of nodal and cutaneous KD have been reported, including ours, and 28 of KD associated with LE (in 13 the diagnosis of KD preceded LE; in nine HNL followed it, and in six the diseases were concomitant) 1–15 . Our patient, an 18‐year‐old Nigerian woman with a history of multiple self‐limiting febrile episodes and idiopathic skin eruptions over the last 8 years, presented with a 2‐week history of fever, cervical and axillary lymphadenopathy, anaemia, leukopenia, and high erythrocyte sedimentation rate.…”

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confidence: 77%

Cutaneous Kikuchi's disease: report of a new case and review of the literature

Goteri¹,

Filosa²,

Pieramici³

et al. 2004

Histopathology

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or metastasis via the lymphatic or venous system-as alluded to by Boyde and Attanoos, 1 although the fact that one is a population-based study and the other an autopsy study may also have an effect.The different mechanisms for metastasis may also account for the wide variation in the survival associated with these lesions (1 week to 67 months), a poor prognosis being associated with direct invasion and prolonged survival indicating a solitary resectable metastasis.

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“…HNL may occur in patients with preexisting SLE, 28 may coexist with SLE, [29][30][31][32] or may evolve into SLE. [33][34][35][36][37][38] Patients with self-limiting HNL, also known as KD, can have a presentation with fever, skin lesions and subacute lymphadenopathy, mimicking SLE clinically and histologically. Whereas KD is mainly limited to lymph nodes, LErelated HNL is more frequently accompanied by cutaneous lesions.…”

Section: Discussionmentioning

confidence: 99%

Interface dermatitis in skin lesions of Kikuchi–Fujimoto’s disease: a histopathological marker of evolution into systemic lupus erythematosus?

Paradela

Lorenzo

Gómez

et al. 2008

Lupus

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Kikuchi's disease (KD) is a self-limiting histiocytic necrotizing lymphadenitis (HNL). Cutaneous manifestations are frequent and usually show histopathological findings similar to those observed in the involved lymph nodes. HNL with superposed histological features to KD has been described in patients with lupus erythematosus (LE), and a group of healthy patients previously reported as having HNL may evolve into LE after several months. Up to date, features to predict which HNL patients will have a self-limiting disease and which could develop LE have been not identified. In order to clarify the characteristics of skin lesions associated with KD, we report a case of HNL with evolution into systemic lupus erythematosus (SLE) and a review of previous reports of KD with cutaneous manifestations. A 17-year-old woman presented with a 4-month history of fever and generalised lymphadenopathy. A diagnosis of HNL was established based on a lymph node biopsy. One month later, she developed an erythematoedematous rash on her upper body, with histopathological findings of interface dermatitis. After 8 months, anti-nuclear antibodies (ANA) at titre of 1/320, anti-DNA-ds antibodies and marked decrease of complement levels were detected. During the following 2 years, she developed diagnostic criteria for SLE, with arthralgias, pleuritis, aseptic meningitis, haemolytic anaemia and lupus nephritis. To our knowledge, 27 cases of nodal and cutaneous KD have been reported, 9 of which later developed LE. In all these patients, the skin biopsy revealed interface dermatitis. Skin biopsy revealed a pattern of interface dermatitis in all reviewed KD cases, which evolved into LE. Even this histopathological finding was not previously considered significant; it might be a marker of evolution into LE.

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Histiocytic necrotizing lymphadenitis preceding systemic lupus erythematosus

Cited by 13 publications

References 24 publications

Histiocytic necrotizing lymphadenitis in the context of systemic lupus erythematosus (SLE): Is histiocytic necrotizing lymphadenitis in SLE associated with skin lesions?

Histiocytic necrotizing lymphadenitis in the context of systemic lupus erythematosus (SLE): Is histiocytic necrotizing lymphadenitis in SLE associated with skin lesions?

Cutaneous Kikuchi's disease: report of a new case and review of the literature

Interface dermatitis in skin lesions of Kikuchi–Fujimoto’s disease: a histopathological marker of evolution into systemic lupus erythematosus?

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