Cutaneous Kikuchi's disease: report of a new case and review of the literature

Abstract

or metastasis via the lymphatic or venous system-as alluded to by Boyde and Attanoos, 1 although the fact that one is a population-based study and the other an autopsy study may also have an effect.The different mechanisms for metastasis may also account for the wide variation in the survival associated with these lesions (1 week to 67 months), a poor prognosis being associated with direct invasion and prolonged survival indicating a solitary resectable metastasis.

Interface dermatitis in skin lesions of Kikuchi–Fujimoto’s disease: a histopathological marker of evolution into systemic lupus erythematosus?

“…neous involvement, but the overall course of the disease was similar to that in patients with isolated lymphadenopathy. 41 From almost 40 patients 32 previously reported as having HNL who later fulfilled diagnostic criteria or developed some features of SLE, we found only nine 5,39,7,9,65,66 with transient cutaneous involvement (Table 3). Patients with coexisting HNL and SLE or those who developed HNL and skin lesions after the diagnosis of SLE were rejected in this study, because we thought that they probably have SLE involving lymph nodes and skin.…”

“…Whereas KD is mainly limited to lymph nodes, LErelated HNL is more frequently accompanied by cutaneous lesions. 39 The main difference between these entities is the prognosis, because most cases of KD require no specific treatment and resolve spontaneously within 1-4 months. 3 Node biopsy in KD shows partial obliteration of the normal follicular architecture by cortical and paracortical focal necrotizing lesions.…”

“…Up to now, the diagnosis of SLE relies on correlation of clinical symptoms with serological abnormalities and KD, excluding SLE and histological demonstration of HNL. 39 After reviewing the literature, we propose that interface dermatitis in skin biopsy could be a histopathological marker of evolution into SLE, and therefore it might help to predict the clinical outcome of KD. Close follow-up of these patients and immunosuppressive therapy should be considered.…”

Lymphadénite histiocytaire nécrosante ou maladie de Kikuchi-Fujimoto

“…Il existe une large variété de lésions, volontiers localisées à la face ou à la partie supérieure du tronc, aucune n'étant spécifique. On décrit ainsi des urticaires, des érythèmes faciaux ou généralisés en principe non prurigineux ressemblant à une rubéole ou à un rash médicamenteux, des rashs morbiliformes, des nodules, des érythèmes papuleux voire même pustuleux, une vascularite leucocytoclasique et un syndrome de Wells (infiltrat dermique riche en polynucléaires éosinophiles associé à des images en flammèches) [21][22][23][24][25][26][27]. Histologiquement, de façon similaire à ce que l'on observe dans les ganglions, les lésions cutanées contiennent dans le derme de nombreux monocytes avec inflexion plasmocytoïde, des histiocytes et de nombreux débris nucléaires [28].…”

“…Plusieurs cas de maladie de KikuchiFujimoto associés à des lupus cutanés subaigus ou discoïdes ont été publiés [30][31][32]. L'immunofluorescence peut alors être discriminante, sa positivité plaidant pour le lupus [27], même si des cas de dépôts de complément et d'immunoglobulines à la jonction dermo-épidermique ont été rapportés dans la maladie de Kikuchi-Fujimoto [33]. Des cas de méningites aseptiques ont été rapportés [31] avec des tableaux cliniques (fièvre, syndrome méningé, LCR à majorité de lymphocytes avec parfois hypoglycorachie, adénite nécrosante) mimant une tuberculose.…”