Lymphadénite histiocytaire nécrosante ou maladie de Kikuchi-Fujimoto

Viallard, Jean‐François; Parrens, Marie; Lazaro, Estibaliz; Caubet, Olivier; Pellegrin, Jean‐Luc

doi:10.1016/j.lpm.2007.06.004

Cited by 14 publications

(2 citation statements)

References 82 publications

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“…The absence of neutrophils and eosinophils is a constant negative sign. The two etiopathogenic hypotheses raised are infectious and autoimmune but none of them is definitively retained until today [14]. The infectious origin is suspected due to frequent association with a viral, bacterial or parasitic infection.…”

Section: Discussionmentioning

confidence: 99%

About a rare disease misdiagnosed as malignant lymphoma or tuberculosis: Kikuchi-Fujimoto’s disease

Lahma¹,

Arkoubi²,

Hejjouji³

et al. 2018

Pan Afr Med J

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Kikuchi-Fujimoto's disease KFD is a rare and benign cause of cervical lymphadenopathy. It is an anatomoclinical entity of unknown etiology. The confirmation of the diagnosis is always provided by histological lymph node study. The clinical picture sometimes evokes lymphoma or tuberculosis. The evolution is generally favorable with spontaneous healing after a few weeks. We report the case of a 26-year-old woman who had consulted for cervical lymphadenopathy associated with fever. The cervical lymph node biopsy concluded to Kikuch-Fujimoto's disease. The evolution was marked by rapid regression of lymphadenopathy under corticosteroid treatment.

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Section: Discussionmentioning

confidence: 99%

About a rare disease misdiagnosed as malignant lymphoma or tuberculosis: Kikuchi-Fujimoto’s disease

Lahma¹,

Arkoubi²,

Hejjouji³

et al. 2018

Pan Afr Med J

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“…Ce déficit génétique, lié dans la majorité des cas à des mutations du gène TNFRSF6 codant pour Fas, pourrait expliquer certaines formes familiales de maladie de Rosai-Dorfman et contribuer à la compréhension de la physiopathologie de cette entité [8]. Viallard et al [3] discutent l'implication d'un agent viral dans le déclenchement de la maladie de Kikuchi-Fujimoto, les recherches les plus récentes concernant surtout l'Epstein-Barr virus (EBV) et le virus Herpès 8. Sur le plan physiopathologique, il semble que le processus d'apoptose soit prépondé-rant dans la maladie de Kikuchi-Fujimoto, à l'origine notamment de la nécrose ganglionnaire, via les voies impliquant Fas et perforine.…”

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Proliférations cellulaires “atypiques” ou “orphelines”: actualités et perspectives

Andrès

Viallard

2007

La Presse Médicale

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Kikuchi‐fujimoto disease in fine‐needle aspiration smears: A clinico‐cytologic study of 76 cases of KFD and 684 cases of reactive hyperplasia of the lymph node

Das

Mallik

Dashti

et al. 2011

Diagnostic Cytopathology

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Kikuchi-Fujimoto disease (KFD) is cytologically characterized by a polymorphous lymphoid cell population, abundant karyorrhectic debris and histiocytes, many of which are crescentic (Kikuchi histiocytes). As per reviewed literature, KFD may be confused with tuberculosis, lymphoma, and reactive hyperplasia of lymph nodes (RHLN). Since RHLN was found to be a major challenging factor during routine cytodiagnosis of KFD in our material, we tried to find out the differentiating clinico-cytologic features between 76 KFD and 684 RHLN cases seen in Kuwait. 63.2% of KFD were in 3rd and 4th decades of life as compared to 40.2% of RHLN (P = 0.0002). Male to female ratio was 1: 2.45 for KFD and 1:1.09 for RHLN (P = 0.0022). Kuwaiti:non-Kuwaiti ratio was 1:2.04 for KFD and 1.31:1 for RHLN (P < 0.0001). Capillary networks was present in 71.1% of KFD smears and 52.6% of RHLN (P = 0.0023). Tingible body macrophages and dendritic reticulum cells were detected in 17.1% and 22.4%, respectively, in KFD as opposed to 50.1% and 58.8%, respectively, in RHLN (P < 0.0001). Kikuchi histiocyte count ranged from 2 to 36% in KFD and was ≥10% in 31 (40.8%). Rare Kikuchi histiocytes were detected in 16 (2.3%) of RHLN cases but in none of them the count exceeded 1%, whereas their count was >1% in all KFD cases (P < 0.0001). Thus, KFD cases differed significantly from RHLN in respect of age and sex distribution, Kuwaiti:non-Kuwaiti ratio, and cytomorphologic features such as capillary networks, Kikuchi histiocyte count, dendritic reticulum cells, and tingible body macrophages.

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Lymphadénite histiocytaire nécrosante ou maladie de Kikuchi-Fujimoto

Cited by 14 publications

References 82 publications

About a rare disease misdiagnosed as malignant lymphoma or tuberculosis: Kikuchi-Fujimoto’s disease

About a rare disease misdiagnosed as malignant lymphoma or tuberculosis: Kikuchi-Fujimoto’s disease

Proliférations cellulaires “atypiques” ou “orphelines”: actualités et perspectives

Kikuchi‐fujimoto disease in fine‐needle aspiration smears: A clinico‐cytologic study of 76 cases of KFD and 684 cases of reactive hyperplasia of the lymph node

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