Histiocytic lesions involving the bone marrow

Chang, Karen L.; Gaal, Karl; Huang, Qin; Weiss, Lawrence M.

doi:10.1016/s0740-2570(03)00030-3

Cited by 20 publications

(5 citation statements)

References 55 publications

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“…ordinary macrophages, CD1a neg dendritic cells), and, therefore, a more specific diagnosis. This is especially important in cases without an established diagnosis, as increased numbers of ordinary macrophages could be found in a number of reactive and neoplastic disorders 11. This is also true for hemophagocytosis, which can be seen in normal marrows, and may be prominent in a variety of diseases.…”

Section: Discussionmentioning

confidence: 99%

Bone marrow assessment in Langerhans cell histiocytosis

Minkov

Pötschger

Grois

et al. 2007

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 99%

Bone marrow assessment in Langerhans cell histiocytosis

Minkov

Pötschger

Grois

et al. 2007

Pediatric Blood & Cancer

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“…The BM, as a source of histiocytic precursor cells and a major home to tissue histiocytes and macrophages, which constitute approximately 10% of its microenvironment, is commonly affected by reactive and neoplastic histiocytic disorders [ 2 ], the latter occurring either primarily or as secondary spread. Histiocytes are usually dispersed throughout the BM (Fig.…”

Section: Introduction To Histiocytic Neoplasms Involving the Bone Marmentioning

confidence: 99%

Histiocytic cell neoplasms involving the bone marrow: summary of the workshop cases submitted to the 18th Meeting of the European Association for Haematopathology (EAHP) organized by the European Bone Marrow Working Group, Basel 2016

et al. 2018

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The bone marrow is a preferential site for both reactive and neoplastic histiocytic proliferations. The differential diagnosis ranges from reactive histiocyte hyperplasia in systemic infections, vaccinations, storage diseases, post myeloablative therapy, due to increased cell turnover, and in hemophagocytic lymphohistiocytosis, through extranodal Rosai-Dorfman disease to neoplasms derived from histiocytes, including histiocytic sarcomas (HS), Langerhans cell histiocytoses (LCH), Erdheim-Chester disease (ECD), and disseminated juvenile xanthogranuloma (JXG). One of the most important recent developments in understanding the biology of histiocytic neoplasms and in contributing to diagnosis was the detection of recurrent mutations of genes of the Ras/Raf/MEK/ERK signaling pathway, in particular the BRAFV600E mutation, in LCH and ECD. Here, we summarize clinical and pathological findings of 17 histiocytic neoplasms that were presented during the bone marrow symposium and workshop of the 18th European Association for Haematopathology (EAHP) meeting held in Basel, Switzerland, in 2016. A substantial proportion of these histiocytic neoplasms was combined with clonally related lymphoid (n = 2) or myeloid diseases (n = 5, all ECD). Based on the latter observation, we suggest excluding co-existent myeloid neoplasms at initial staging of elderly ECD patients. The recurrent nature of Ras/Raf/MEK/ERK signaling pathway mutations in histiocytic neoplasms was confirmed in 6 of the 17 workshop cases, illustrating their diagnostic significance and suggesting apotential target for tailored treatments.

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“…Although bone marrow examination is a common procedure in the evaluation of patients with cancer and other non-haematologic disorders, its role and contribution have been questioned in recent years.Metastatic involvement with tumors [4] ,granulomatous diseases [3] , storage disorders [10], haemophagocytic Syndrome [6,11] , histiocytoses [7] and Leishmaniasis [8,9] can be diagnosed through bone marrow examination. In addition to hematological malignancies; bone marrow examination has been increasingly useful in documenting metastatic involvement of tumors .…”

Section: Introductionmentioning

confidence: 99%

Bone Marrow Involvement in Non Hematological Disorders – An Institutional Experience

Panigrahi¹,

Behera²,

P³

2017

IOSR JDMS

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Objective: To find out the frequency of involvement of bone marrow by nonhaematological disorders in our institution and to evaluate the role of bone marrow aspiration and biopsy in diagnosing these disorders. Materials & Methods: It was a retrospective study that extended from January 2013 to December 2016. A total of 339 bone marrow aspirates and trephine biopsies were performed during this period. Only the nonhaematological disorders were studied and their clinical and laboratory parameters were recorded. Peripheral blood picture was studied. Bone marrow aspiration smears & biopsies were evaluated. Results: During the study period, 29 patients were diagnosed to have non-haematological disorders which constituted 8.5% of the total patients who had undergone bone marrow examination. The age of patients at time of procedure ranged from 3 years to 84years, with male to female ratio of 2.2 :1. Anemia was the most frequent clinical finding followed by fever and weight loss. In adults, metastatic tumors were the commonest non hematological condition diagnosed on bone marrow examination. In children also, metastatic tumors were the commonest non-hematological disease. Conclusion: Metastatic solid tumors were the frequent non-hematologic disorders involving bone marrow in both adults and pediatric patients. Hence, bone marrow examination can be a safe, easy and useful laboratory tool in the diagnosis of various metastatic malignancies and other disorders like granulomatous lesions.

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Histiocytic lesions involving the bone marrow

Cited by 20 publications

References 55 publications

Bone marrow assessment in Langerhans cell histiocytosis

Bone marrow assessment in Langerhans cell histiocytosis

Histiocytic cell neoplasms involving the bone marrow: summary of the workshop cases submitted to the 18th Meeting of the European Association for Haematopathology (EAHP) organized by the European Bone Marrow Working Group, Basel 2016

Bone Marrow Involvement in Non Hematological Disorders – An Institutional Experience

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