Bone Marrow Involvement in Non Hematological Disorders – An Institutional Experience

Abstract

Objective: To find out the frequency of involvement of bone marrow by nonhaematological disorders in our institution and to evaluate the role of bone marrow aspiration and biopsy in diagnosing these disorders. Materials & Methods: It was a retrospective study that extended from January 2013 to December 2016. A total of 339 bone marrow aspirates and trephine biopsies were performed during this period. Only the nonhaematological disorders were studied and their clinical and laboratory parameters were recorded. Peripheral blood picture was studied. Bone marrow aspiration smears & biopsies were evaluated. Results: During the study period, 29 patients were diagnosed to have non-haematological disorders which constituted 8.5% of the total patients who had undergone bone marrow examination. The age of patients at time of procedure ranged from 3 years to 84years, with male to female ratio of 2.2 :1. Anemia was the most frequent clinical finding followed by fever and weight loss. In adults, metastatic tumors were the commonest non hematological condition diagnosed on bone marrow examination. In children also, metastatic tumors were the commonest non-hematological disease. Conclusion: Metastatic solid tumors were the frequent non-hematologic disorders involving bone marrow in both adults and pediatric patients. Hence, bone marrow examination can be a safe, easy and useful laboratory tool in the diagnosis of various metastatic malignancies and other disorders like granulomatous lesions.

Study of Spectrum of Lesions in Bone Marrow Aspiration and Trephine Biopsy from a Tertiary Care Centre in South India

“…The number of male patients in the present study were 63% and the female patients were 37% with a male to female ratio of 1.7:1. This was in concordance with the studies done by Goyal, et al [5], Panigrahi, et al [6], Khan, et al [7], Atchyuta, et al [9], and Birare, et al [10].…”

“…The basic panel markers 85 years, with the mean age being 50.22 years. The age distribution was comparable to the studies conducted by Panigrahi, et al [6], Khan, et al [7], Tyagi, et al [8] and Atchyuta, et al [9].…”

Bone Marrow Involvement in Non-Hematological Malignancy: A Clinico-pathological Study From a Tertiary Hospital

“…However, few studeis showed anaemia as a most comman hematological abnormality during metastasis in bone marrow. [14,15] Newer techniques are used to demonstrate marrow involvement in early stage disease for this immunohistochemistry , flow cytometry and PCR techniques are used. These techniques indicate a greater frequency of tumor infiltration than has been evident, from standard histological methods.…”