Bone Marrow Involvement in Non-Hematological Malignancy: A Clinico-pathological Study From a Tertiary Hospital

JalalyMeenai, Farah; Ojha, Sandeep; Ali, Manal Ashraf; Jain, Rubal; Sawke, Nilima

doi:10.21276/apalm.1723

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…BM metastases are diagnosed in 0.2%-12% patients with solid malignancies. In adults, BM metastases of breast, lung and prostate cancers are observed most frequently after lymphomas (3). However, it is even rarer for patients without a diagnosis of malignancy to be diagnosed with BM metastasis.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Solid Tumor Patients Presenting with Denovo Bone Marrow Metastasis

BAYİR GARBİOGLU,

YILDIZ,

IŞIKSOY

et al. 2023

Batı Karadeniz Tıp Dergisi

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Aim: Although solid tumors are known to metastasize to the bone marrow, it is rare to be diagnosed with bone marrow involvement. In our study, we aimed to contribute to the literature by evaluating the treatment results and follow-up processes of different solid tumors metastatic to bone marrow in denovo. Material and Methods: We retrospectively analyzed 28 patients who underwent bone marrow biopsy with a prediagnosis of hematologic malignancy and were diagnosed with carcinoma metastasis. Clinicopathologic features, antitumor treatments, treatment-related hematologic toxicities and factors affecting survival were evaluated. Results: Of the 28 patients included in the study, 14 (50.0%) were female and 14 (50.0%) were male. The median age of the patients was 62 years (28-82). Eight patients (28.6%) were diagnosed with breast (28.6%), six with gastric (21.4%), four with lung (14.3%), two each with colon and prostate ca (7.1%), and the primary tumor site could not be determined in six patients (21.4%). Progression was observed in four (40.0%) of the 10 patients with the first series of treatment, three (30.0%) patients had stable response and three (30.0%) patients had partial response. The median progression-free survival time was 130 days (3-494 days) in patients who received first line treatment. The median overall survival time was 26 days (0-1183 days). Thrombocytopenia (p

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Section: Introductionmentioning

confidence: 99%

Evaluation of Solid Tumor Patients Presenting with Denovo Bone Marrow Metastasis

BAYİR GARBİOGLU,

YILDIZ,

IŞIKSOY

et al. 2023

Batı Karadeniz Tıp Dergisi

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The necessity of bilateral staging bone marrow examinations for paediatric solid tumours

et al. 2022

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Background: Bone marrow aspirates and trephine biopsies (BMATs) form an important part of staging to detect bone marrow metastases of both haematological and nonhaematological neoplasms.Aim: The study’s primary aim was to determine whether it is necessary to perform bilateral BMATs on paediatric cancer patients as opposed to unilateral BMATs for the staging of solid tumours.Setting: The Paediatric Oncology Unit at Universitas Academic Hospital (UAH) in Bloemfontein, Free State, South Africa.Methods: A retrospective descriptive study was performed using laboratory reports from 01 January 2015 to 31 December 2019. Data were collected and reported on regarding the total number of staging BMATs performed, the average length of the trephine biopsies, the number of BMATs used for primary diagnosis, the number of bone marrow specimens where metastases were detected (left, right or both), the type of primary cancer and demographic information.Results: One hundred and eighteen patients were included for interpretation. Bone marrow metastases were detected in 28 patients, of which five patients had discrepant left and right results. These five cases included nephroblastoma (n = 2), Hodgkin lymphoma (n = 2) and a germ cell tumour (n = 1).Conclusion: Discrepant results were found in five cases (n = 28; 17.8%). Ultimately, the clinical implication of incorrectly staging solid tumours outweighs the small risks and discomfort of a bilateral bone marrow biopsy.

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Bone Marrow Involvement in Non-Hematological Malignancy: A Clinico-pathological Study From a Tertiary Hospital

Abstract: Background: Bone marrow is an important site for metastasis in cases of non hematological malignancies and is routinely performed to stage the disease or to rule out metastasis in suspected cases..

Cited by 2 publications

References 10 publications

Evaluation of Solid Tumor Patients Presenting with Denovo Bone Marrow Metastasis

Evaluation of Solid Tumor Patients Presenting with Denovo Bone Marrow Metastasis

The necessity of bilateral staging bone marrow examinations for paediatric solid tumours

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