Histidine decarboxylase in mouse foetal tissues. II. Physiological role of the enzyme in delivery

Maśliński, Cz.; Niedzielski, Antoni

doi:10.1016/0014-2999(69)90030-2

Cited by 6 publications

(4 citation statements)

References 45 publications

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“…Moreover, it has been inferred that these actions were due to inhibition of histidine decarboxylase (Pelczarska, 1969;Pena, 1966;Maslinski & Niedzielski, 1969).…”

Section: Resultsmentioning

confidence: 99%

“…In recent years, claims have been made that a tetrahydroisoquinoline derivative, known variously as Hypostamine, Tritoqualine or 554-L, possessed a variety of pharmacological properties including anti-allergic (Hahn, Teschendorf & others, 1970) and anti-inflammatory (Pelczarska, 1969) activity. Moreover, it has been inferred that these actions were due to inhibition of histidine decarboxylase (Pelczarska, 1969;Pena, 1966;Maslinski & Niedzielski, 1969).…”

Section: Resultsmentioning

confidence: 99%

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The inhibition of histamine formationin vivo

Mole

Shepherd

1973

Journal of Pharmacy and Pharmacology

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Histamine formation was measured by the [14C]histamine content of the stomach following injection of [14C]histidine into rats. Carbonyl reagents (e.g. oxyamines) which inactivate pyridoxal phosphate, the co-enzyme of histidine decarboxylase, were the most effective inhibitors of histamine formation in vivo. Although the oximes prepared from imidazol-4(5)-ylmethoxyamine and pyridoxal or pyridoxal phosphate cannot inactivate the co-enzyme, they proved sufficiently potent to merit further study as inhibitors of histamine formation in vivo.Many compounds of diverse chemical structure are active in vitro as histidine decarboxylase inhibitors. Of these only a few, mainly carbonyl reagents such as oxyamines and hydrazine derivatives which inactivate the co-enzyme pyridoxal phosphate (PLP), have been shown to inhibit histamine formation in vivo (Levine, Sat0 & Sjoerdsma, 1965;Johnston & Kahlson, 1967;Reilly & Schayer, 1968;Hakanson & Liedberg, 1972;Kobayashi, Kupelian & Maudsley, 1970;Menon, Clark & Aures, 1971). Carbonyl reagents are generally extremely potent inhibitors of histidine decarboxylase, but because of their action on the co-enzyme they lack specificity and may thus also inhibit other PLP-dependent enzymes.A procedure for the screening of potential inhibitors of histidine decarboxylase in vivo is now described and applied to the evaluation of compounds selected from those previously studied in vitro (Mole & Shepherd, 1972). MATERIALS A N D METHODS DrugsWe Oxime (PLPZMA) of pyridoxal phosphate and imidazol-4(5)-ylmethoxyamineImidazol-4(5)-ylmethoxyamine dihydrochloride (IMA) (Mole & Shepherd, 1972) (1.86 g, 0.01 mol) was dissolved in 50 ml water and added to solid pyridoxal phosphate monohydrate (2.658, 0.01 mol). The mixture was stirred until a clear solution was obtained (about 30 min) and set aside at 4" for 2 h. Sodium bicarbonate (1*68g, 0.02 mol) in 50 ml water was added during 30 min to the stirred solution which was then left overnight at 4". The yellow solid which separated was removed by filtration and washed carefully with ice-cold water to give 2.80g (78 %) of oxime, mp 178-183".

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“…Moreover, it has been inferred that these actions were due to inhibition of histidine decarboxylase (Pelczarska, 1969;Pena, 1966;Maslinski & Niedzielski, 1969).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The inhibition of histamine formationin vivo

Mole

Shepherd

1973

Journal of Pharmacy and Pharmacology

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“…tritoqualine [16], IAB [8], and TMA [7] were tested. Tritoqualine, being water insoluble, was given as a suspension in saline; the dose for all was 1 mg/20 g. Thirty minutes after drug injection, mice received 14C-g-histidine 2 ~Ci, were sacrificed 5 minutes later and stomachs assayed.…”

Section: Experiments 11 Several Alleged Inhibitorsmentioning

confidence: 99%

Effect of histidine decarboxylase inhibitors and other drugs on histamine formation in vivo

Schayer

Reilly

1974

Agents and Actions

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A number of compounds alleged to inhibit histidine decarboxylase in vitro and in vivo, were tested in mice for ability to reduce histamine formation in cell types containing this enzyme. Mice were pretreated with 'inhibitor' or saline, injected with 14C-L-histidine, and after an interval suitable for each cell type, sacrificed. For mast cell histidine decarboxylase, skin was assayed; for enzyme in enteroehromaflin-like cells, stomach was assayed; for brain ceils (cell type unidentified at present) whole brain was assayed. Most tested compounds had little or no effect on histamine formation. Only one drug, 4-imidazole-3-amino-2-butanone showed strong activity in both skin and stomach samples; it did not affect brain histamine formation, possibly because it does not enter brain.

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“…Just be fore term sensitivity increases again. Concluding from their experiments on the inhibition of HDC by a-hydrazine histidine and 554-l, M aslinski and N iedzielski [19] suggested, that the fall in HDC activity does not directly in duce delivery, but triggers another mechanism which is responsible for deliv ery.…”

Section: Discussionmentioning

confidence: 99%