Histamine Receptor H1–Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

Wouters, Mira M.; Balemans, Dafne; Wanrooy, Sander Van; Dooley, James; Cibert-Goton, Vincent; Alpízar, Yeranddy A.; Valdez-Moráles, Eduardo E.; Nasser, Yasmin; Veldhoven, Paul P. Van; Vanbrabant, Winde; Merwe, Schalk van der; Mols, Raf; Ghesquière, Bart; Cirillo, Carla; Kortekaas, I. J. M.; Carmeliet, Peter; Peetermans, Willy; Vermeire, Séverine; Rutgeerts, Paul; Augustijns, Patrick; Hellings, Peter W.; Belmans, Ann; Vanner, Stephen; Bulmer, D; Talavera, Karel; Berghe, Pieter Vanden; Liston, Adrian; Boeckxstaens, Guy E.

doi:10.1053/j.gastro.2015.12.034

Cited by 278 publications

(291 citation statements)

References 43 publications

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“…We consider that evaluation by TDI parallels the evaluation by HRM. The chemical cascade of the TRPV1 receptor affects GI peristalsis via the GI sensory nerve [45,46]. This mechanism is expected to be applied to treatment of GI tract of functional disorders, such as irritable bowel syndrome [45,46].…”

Section: Discussionmentioning

confidence: 99%

“…The chemical cascade of the TRPV1 receptor affects GI peristalsis via the GI sensory nerve [45,46]. This mechanism is expected to be applied to treatment of GI tract of functional disorders, such as irritable bowel syndrome [45,46]. Therefore, there might have been some changes in esophageal peristalsis before and after capsaicin administration in patients who responded to capsaicin.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Capsaicin on Older Patients with Oropharyngeal Dysphagia: A Double-Blind, Placebo-Controlled, Crossover Study

Nakato¹,

Manabe²,

Shimizu

et al. 2017

Digestion

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Background/Aims: The standard of care for older patients with oropharyngeal dysphagia (OD) is poor. Stimulation of transient receptor potential vanilloid 1 might become a pharmacological strategy for these patients. This study aimed to compare the therapeutic effect of film food containing 0.75 µg of capsaicin in these patients. Methods: In a crossover, randomized trial, 49 patients with OD were provided capsaicin or identical placebo at least 7 days apart. Patients' reported symptoms during repeated swallowing, the volume, pH and substance P (SP) concentrations in saliva, and cervical esophageal wall motion evaluated by ultrasonographic tissue Doppler imaging were obtained before and after capsaicin or placebo administration. Results: Significantly more patients with OD who took capsaicin experienced improvement in symptoms than those who took placebo. Salivary SP levels were significantly increased after capsaicin administration compared with placebo in the effective group. The duration of cervical esophageal wall opening was significantly shorter in capsaicin administration in the effective group. Furthermore, a significant negative correlation was found between the duration of cervical esophageal wall opening and salivary SP levels. Conclusion: Elevated salivary SP concentrations stimulated by capsaicin greatly improve the safety and efficacy of swallowing, and shorten the swallow response in older patients with OD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Capsaicin on Older Patients with Oropharyngeal Dysphagia: A Double-Blind, Placebo-Controlled, Crossover Study

Nakato¹,

Manabe²,

Shimizu

et al. 2017

Digestion

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“…There is a large body of evidence suggesting that MCs are an important factor in the pathophysiology of IBS. 39 IBS patients have an increased number of MCs, which contain granules rich in mediators such as histamine, tryptase, and nerve growth factors that can activate and sensitize enteric nerves, and modulate the integrity of the epithelial barrier. 57,58 An increased number of mucosal MCs has been observed in biopsy samples from the rectum, 59 rectosigmoid, 60 descending colon, 43 ascending colon, 59 cecum, 61 terminal ileum, 59 jejunum, 62 and duodenum 63 of patients with IBS.…”

Section: -41mentioning

confidence: 99%

“…39 Interestingly, the transient receptor potential vanilloid 1 (TRPV1) was found to be implicated in the process; either histamine alone or the supernatant from rectal biopsies from patients with IBS sensitize TRPV1 channels. Upon activation by stimuli such as noxious heat, acidosis or endovanilloids, TRPV1 becomes non-selectively permeable for ions.…”

Section: Possible Application Of Anti-histamine Drugs In Irritable Bomentioning

confidence: 99%

Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal

Fabisiak

Włodarczyk

Fabisiak

et al. 2017

J Neurogastroenterol Motil

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Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed.

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“…Based on another study, the mast cell-stabilizer ketotifen decreased abdominal pain and improved the quality of life of the IBS patients 88 . Moreover, the histamine 1 (H1)-receptor blocker ebastine decreases abdominal pain scores and improves symptom in IBS 89 .…”

Section: Anti-inflammatory Medications For Ibsmentioning

confidence: 99%

Immune activation in irritable bowel syndrome: from basic to clinic

Bashashati¹

2022

NGL

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RESUMENEl síndrome de intestino irritable (SII) es un trastorno funcional intestinal común con una etiología no identificada. La activación de bajo grado del sistema autoinmunitario ha sido considerada la fisiopatología de este trastorno. En los pacientes que lo padecen, las concentraciones de citocinas están alteradas y las células inmunitarias se infiltran en el intestino. Además, en los pacientes con SII se ha observado la activación de estas células inmunitarias y la presencia de alergias alimenticias. Sin embargo, las características del perfil inmunológico de los pacientes con SII pueden ser objeto de debate en la práctica clínica, dado que no existen criterios bien establecidos para diferenciar el SII en controles sanitarios basados en estos parámetros. Esta revisión plantea el rol del sistema inmunitario en la fisiopatología del SII y explora los potenciales roles de estos biomarcadores durante el tratamiento clínico de estos pacientes.

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Histamine Receptor H1–Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

Cited by 278 publications

References 43 publications

Effects of Capsaicin on Older Patients with Oropharyngeal Dysphagia: A Double-Blind, Placebo-Controlled, Crossover Study

Effects of Capsaicin on Older Patients with Oropharyngeal Dysphagia: A Double-Blind, Placebo-Controlled, Crossover Study

Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal

Immune activation in irritable bowel syndrome: from basic to clinic

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