Histamine receptor 2 is a key influence in immune responses to intestinal histamine-secreting microbes

Ferstl, Ruth; Frei, Remo; Schiavi, Elisa; Konieczna, Patrycja; Barcik, Weronika; Ziegler, Mario; Lauener, Roger; Chassard, Christophe; Lacroix, Christophe; Akdiş, Cezmi A.; O’Mahony, Liam

doi:10.1016/j.jaci.2014.04.034

Cited by 61 publications

(53 citation statements)

References 9 publications

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“…An increased level of histamine in the gastrointestinal tract is associated with a range of mucosal inflammatory disorders [20,22]. In this study, elevated histamine production was observed in the presence of AAs only with strains M. morganii and L. vaginalis , as previously reported by others [33,34].…”

Section: Discussionsupporting

confidence: 88%

“…Histamine can have both pro-inflammatory and anti-inflammatory effects on immunoregulatory processes, depending on which histamine receptor is activated [18,19]. We previously demonstrated that Lactobacillus saerimneri 30a (which secretes histamine and cadaverine) induces rapid weight loss and immunological effects, dependent on activation of histamine receptor-2 within the mucosa [20]. In addition, the levels of histamine-secreting bacteria were shown to be increased in the gut of asthma patients compared to healthy volunteers, and the level of one histamine-secreting microbe positively correlated with the severity of disease [21].…”

Section: Introductionmentioning

confidence: 99%

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A wide diversity of bacteria from the human gut produces and degrades biogenic amines

Pugin

Barcik

Westermann

et al. 2017

Microbial Ecology in Health and Disease

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120

118

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Background: Biogenic amines (BAs) are metabolites produced by the decarboxylation of amino acids with significant physiological functions in eukaryotic and prokaryotic cells. BAs can be produced by bacteria in fermented foods, but little is known concerning the potential for microbes within the human gut microbiota to produce or degrade BAs.Objective: To isolate and identify BA-producing and BA-degrading microbes from the human gastrointestinal tract.Design: Fecal samples from human volunteers were screened on multiple growth media, under multiple growth conditions. Bacterial species were identified using 16S rRNA sequencing and BA production or degradation was assessed using ultra-performance liquid chromatography.Results: In total, 74 BA-producing or BA-degrading strains were isolated from the human gut. These isolates belong to the genera Bifidobacterium, Clostridium, Enterococcus, Lactobacillus, Pediococcus, Streptococcus, Enterobacter, Escherichia, Klebsiella, Morganella and Proteus. While differences in production or degradation of specific BAs were observed at the strain level, our results suggest that these metabolic activities are widely spread across different taxa present within the human gut microbiota.Conclusions: The isolation and identification of microbes from the human gut with BA-producing and BA-degrading metabolic activity is an important first step in developing a better understanding of how these metabolites influence health and disease.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

A wide diversity of bacteria from the human gut produces and degrades biogenic amines

Pugin

Barcik

Westermann

et al. 2017

Microbial Ecology in Health and Disease

Self Cite

120

118

View full text Add to dashboard Cite

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“…The enzyme histidine decarboxylase (HDC) is responsible for histamine synthesis from the amino acid l -histidine. Of note, histamine can be also produced (from l -histidine via HDC) by some fermentative bacteria, including Lactobacilli in the gut [29,30]. This, coupled with recent knowledge about the potential role played by the skin microbiome in AD (reviewed in [31,32,33]), suggests a fascinating mechanism by which cutaneous bacteria might influence skin homeostasis.…”

Section: Histamine Overviewmentioning

confidence: 99%

Histamine and Skin Barrier: Are Histamine Antagonists Useful for the Prevention or Treatment of Atopic Dermatitis?

Benedetto

Yoshida

Fridy

et al. 2015

JCM

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Atopic Dermatitis (AD), the most common chronic inflammatory skin disease, is characterized by an overactive immune response to a host of environmental allergens and dry, itchy skin. Over the past decade important discoveries have demonstrated that AD develops in part from genetic and/or acquired defects in the skin barrier. Histamine is an aminergic neurotransmitter involved in physiologic and pathologic processes such as pruritus, inflammation, and vascular leak. Enhanced histamine release has been observed in the skin of patients with AD and antihistamines are often prescribed for their sedating and anti-itch properties. Recent evidence suggests that histamine also inhibits the terminal differentiation of keratinocytes and impairs the skin barrier, raising the question whether histamine might play a role in AD barrier impairment. This, coupled with the notion that histamine’s effects mediated through the recently identified histamine receptor H4R, may be important in allergic inflammation, has renewed interest in this mediator in allergic diseases. In this paper we summarize the current knowledge on histamine and histamine receptor antagonists in AD and skin barrier function.

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“…In vivo, histamine producing L. reuteri strains ameliorate inflammation in vivo in a trinitrobenzene sulfonic acid (TNBS)-induced mouse model of acute colitis (26, 31). Likewise histamine from L saerimneri strain 30a (ATCC 33222) was able to significant lower NFkB activation in human monocytoid cells and suppress IL-17 and IFN-γ secretion in wild-type mice, but not in H2R-deficient animals (32). Histamine has also been demonstrated to alter dendritic cell (DC) responses to microbial ligands (33).…”

Section: Signaling Compoundsmentioning

confidence: 99%

Biochemical Features of Beneficial Microbes: Foundations for Therapeutic Microbiology

Engevik

Versalovic

2017

Microbiol Spectr

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Commensal and beneficial microbes secrete myriad products which target the mammalian host and other microbes. These secreted substances aid in bacterial niche development, and select compounds beneficially modulate the host and promote health. Microbes produce unique compounds which can serve as signaling factors to the host, such as biogenic amine neuromodulators, or quorum-sensing molecules to facilitate inter-bacterial communication. Bacterial metabolites can also participate in functional enhancement of host metabolic capabilities, immunoregulation, and improvement of intestinal barrier function. Secreted products such as lactic acid, hydrogen peroxide, bacteriocins, and bacteriocin-like substances can also target the microbiome. Microbes differ greatly in their metabolic potential and subsequent host effects. As a result, knowledge about microbial metabolites will facilitate selection of next-generation probiotics and therapeutic compounds derived from the mammalian microbiome. In this article we describe prominent examples of microbial metabolites and their effects on microbial communities and the mammalian host.

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Histamine receptor 2 is a key influence in immune responses to intestinal histamine-secreting microbes

Cited by 61 publications

References 9 publications

A wide diversity of bacteria from the human gut produces and degrades biogenic amines

A wide diversity of bacteria from the human gut produces and degrades biogenic amines

Histamine and Skin Barrier: Are Histamine Antagonists Useful for the Prevention or Treatment of Atopic Dermatitis?

Biochemical Features of Beneficial Microbes: Foundations for Therapeutic Microbiology

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