Histamine Quantification in Human Blood Samples

Tiligada, Ekaterini; Kakolyri, Maria; Ennis, Madeleine

doi:10.1007/978-1-4939-6843-5_17

Cited by 2 publications

(1 citation statement)

References 80 publications

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“…The method described by Tiligada et al [33] was adopted. Briefly, 5.0 ml of blood collected from cardiac puncture of rat heart was taken in a test tube and to it 4.5 ml distilled water and 0.5 ml 10 -12 N HClO 4 (perchloric acid) were added, After keeping for 10 minutes at room temperature, 9 ml of 0.4N.…”

Section: Estimation Of Release Of Histamine From Bloodmentioning

confidence: 99%

Evaluation of Anti-Inflammatory and Anti-Arthritic Activities of AV11-03 in Female Rats

2023

JCMAH

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Rheumatiod arthritis is a systemic auto-immune disease characterized by chronic inflammation at multiple synovial joints, cartilage destruction and bone erosion. Currently available non-steroidal anti-inflammatory drugs, cortico-steroids and disease modifying anti-rheumatic therapies have severe side effects on prolonged use and thus throw a challenge for development of safe, effective alternatives. Of the many plant drugs claimed to be effective in the treatment of rheumatoid arthritis, in depth studies were carried out on the fruits of Terminalia chebula (Haradae) and the oleo-gum resin of Boswellia serrata (Sallaki). Glucosamine was shown to be chondrio-protective and effective in osteo-arthritis. Hence, we tested ‘AV-11 03’ which is a combination of the extracts of haradae, salliki an maize glucosamine on acute and chronic inflammatory models by studying a battery of physical, biochemical, histological and radiological parameters.

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Section: Estimation Of Release Of Histamine From Bloodmentioning

confidence: 99%

Evaluation of Anti-Inflammatory and Anti-Arthritic Activities of AV11-03 in Female Rats

2023

JCMAH

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Increased Basal Blood Histamine Levels in Patients with Self-Reported Hypersensitivity to Non-Steroidal Anti-Inflammatory Drugs

Kakolyri

Strikou

Kavallari

et al. 2019

Int Arch Allergy Immunol

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Background: Non-steroidal anti-inflammatory drugs (NSAIDs) represent one of the most prevalent causes of drug hypersensitivity reactions (DHRs), yet the underlying processes are far from clear. Despite the established role of histamine in allergic reactions, its precise implication in DHRs is elusive. Objectives: This study aimed to explore the connection of basal blood histamine levels to the reported NSAID hypersensitivity. Methods: Sixteen patients reporting hypersensitivity reactions to a single or multiple NSAIDs and/or paracetamol and 18 healthy volunteers serving as the normal control group enrolled in the study. The medical history was recorded and histamine was quantified spectrophotofluorometrically in whole peripheral blood and plasma. Results: Compared to the normal group, plasma but not whole blood histamine levels were significantly higher in patients (p < 0.001), mainly in the subgroup reporting hypersensitivity to a single agent (p < 0.001). Plasma histamine levels were significantly correlated with the culprit drug selectivity for cyclooxygenase (COX) isozymes (p < 0.001), with higher levels being obtained in patients reporting reactions to COX-1 than to COX-2 selective inhibitors (p < 0.05). Conclusions: The findings provide first evidence connecting basal blood histamine levels to the reported NSAID-triggered DHRs. Prospective studies are expected to decipher the contribution of histamine-associated parameters to the mechanisms underlying DHRs.

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Histamine Quantification in Human Blood Samples

Cited by 2 publications

References 80 publications

Evaluation of Anti-Inflammatory and Anti-Arthritic Activities of AV11-03 in Female Rats

Evaluation of Anti-Inflammatory and Anti-Arthritic Activities of AV11-03 in Female Rats

Increased Basal Blood Histamine Levels in Patients with Self-Reported Hypersensitivity to Non-Steroidal Anti-Inflammatory Drugs

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