Histamine protects bone marrow against cellular damage induced by ionising radiation

Abstract

Histamine reduces ionising radiation toxicity on bone marrow cells being a suitable candidate for use as radioprotector, especially for patients undergoing radiotherapy who are at the risk of bone marrow or small intestine damage.

Histamine prevents functional and morphological alterations of submandibular glands induced by ionising radiation

“…Rats were maintained in our animal healthcare facility at 22-248C and 50-60% humidity on a 12 h light/dark cycle with food and water available ad libitum. To determine the potential radioprotective effect of histamine on SMG, the same experimental procedures that we previously described in detail to evaluate the radioprotective effect on small intestine and bone marrow were used (Medina et al 2007(Medina et al , 2010.…”

“…Histamine prevents radiation-induced toxicity in the small intestine by increasing proliferation of damaged intestinal mucosa and also by suppressing apoptosis (Medina et al 2007(Medina et al , 2010. In addition, histamine has the ability to enhance the radiosensitivity of malignant breast cells (Medina et al 2006).…”

Enhancement of ionizing radiation response by histamine in vitro and in vivo in human breast cancer

“…3,4 In this regard, it was reported that histamine significantly protects small intestine and bone marrow, from high doses of ionizing radiation, in 2 models of rodents. [5][6][7] In addition, histamine has the ability to prevent ionizing radiation-induced functional and histological alterations of salivary glands. 8 These features make histamine a suitable candidate as a radioprotector for patients undergoing radiotherapy.…”

Histamine and Breast Cancer: A New Role for a Well Known Amine

“…Recently we have established a radioprotective role of histamine on bone marrow against cellular damage induced by ionizing radiation (Medina et al, 2010). We have also proved that histamine prevents radiation-induced toxicity on small intestine by modulating the antioxidant enzymes expression and by suppressing apoptosis and increasing proliferation of damaged intestinal mucosa (Medina et al, 2007).…”