Histamine and Breast Cancer: A New Role for a Well Known Amine

Cricco, G.; Mohamad, Nora; Sáez, María Soledad Cruz; Valli, Eduardo; Rivera, Elena; Martin, G. Saint

doi:10.5772/20633

Cited by 6 publications

(5 citation statements)

References 73 publications

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“…S2A). Remarkably, results were comparable with those previously reported in non irradiated MDA-MB-231 cells [9].…”

Section: Enhancement Of Emt Functional Markers In Irradiated Breast C...supporting

confidence: 92%

“…Increasing evidence has also been collected indicating that histamine might be a player in tumor progression modulating cell adhesion and MMPs activity in pancreatic and mammary tumor cells [9,10]. We have reported that ionizing radiation induced some EMT-related events in the TNBC cells MDA-MB-231 which were blocked upon histamine treatment before cell irradiation [9].…”

Section: Introductionmentioning

confidence: 83%

“…Since the expression of EMT molecular markers is tightly related to functional markers we next performed assays to investigate the gelatinolytic activity, cell migration and invasion. We have previously reported that histamine in high concentration could block the significant increase in the MMPs activity and the migratory/invasive capacity induced by a single dose of 2 Gy gamma-radiation in the TNBC cells MDA-MB-231 [9].…”

Section: Enhancement Of Emt Functional Markers In Irradiated Breast C...mentioning

confidence: 99%

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Histamine prevents radiation-induced mesenchymal changes in breast cancer cells

Galarza

Mohamad

Delgado

et al. 2016

Pharmacological Research

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“…S2A). Remarkably, results were comparable with those previously reported in non irradiated MDA-MB-231 cells [9].…”

Section: Enhancement Of Emt Functional Markers In Irradiated Breast C...supporting

confidence: 92%

Section: Introductionmentioning

confidence: 83%

Section: Enhancement Of Emt Functional Markers In Irradiated Breast C...mentioning

confidence: 99%

See 1 more Smart Citation

Histamine prevents radiation-induced mesenchymal changes in breast cancer cells

Galarza

Mohamad

Delgado

et al. 2016

Pharmacological Research

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“…Lung micrometastases were not modified upon histamine and clozapine treatments, while JNJ28620144 increased the number of micrometastases. In this line, H 4 R agonists increased matrix metalloproteinases 2 and 9 that participate in the proteolysis of basement membrane and extracellular matrix proteins, and also enhanced invasiveness of MDA‐MB‐231 cells in vitro , which are critical steps for cancer metastases (Cricco et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Therapeutic potential of histamine H₄ receptor agonists in triple‐negative human breast cancer experimental model

Lamas

Croci²,

Carabajal

et al. 2013

British J Pharmacology

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BACKGROUND AND PURPOSEThe presence of the histamine H4 receptor (H4R) was previously reported in benign and malignant lesions and cell lines derived from the human mammary gland. The aim of this work was to evaluate the effects of H4R ligands on the survival, tumour growth rate and metastatic capacity of breast cancer in an experimental model. EXPERIMENTAL APPROACHXenograft tumours of the highly invasive human breast cancer cell line MDA-MB-231 were established in immune deficient nude mice. The following H4R agonists were employed: histamine (5 mg kg RESULTSData indicate that developed tumours were highly undifferentiated, expressed H4R and exhibited high levels of histamine content and proliferation marker (PCNA) while displaying low apoptosis. Mice of the untreated group displayed a median survival of 60 days and a tumour doubling time of 7.4 Ϯ 0.6 days. A significant decrease in tumour growth evidenced by an augment of the tumour doubling time was observed in the H4R agonist groups (13.1 Ϯ 1.2, P < 0.01 in histamine group; 15.1 Ϯ 1.1, P < 0.001 in clozapine group; 10.8 Ϯ 0.7, P < 0.01 in JNJ28610244 group). This effect was associated with a decrease in the PCNA expression levels, and also reduced intratumoural vessels in histamine and clozapine treated mice. Histamine significantly increased median survival (78 days; Log rank Mantel-Cox Test, P = 0.0025; Gehan-Breslow-Wilcoxon Test, P = 0.0158) and tumoural apoptosis. CONCLUSIONS AND IMPLICATIONSHistamine through the H4R exhibits a crucial role in tumour progression. Therefore, H4R ligands offer a novel therapeutic potential as adjuvants for breast cancer treatment. LINKED ARTICLESThis article is part of a themed issue on Histamine Pharmacology Update. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2013.170.issue-1 AbbreviationsBrdU, 5-bromo-2′-deoxyuridine; ER, oestrogen receptor; H1R, histamine receptor 1; H2R, histamine receptor 2; H3R, histamine receptor 3; H4R, histamine receptor 4; siRNA, small interfering RNA

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“…To further confirm the involvement of H 4 R in the reduction of proliferation, H 4 R small interfering RNA (siRNA) was employed to knock-down the H 4 R expression resulting in the blockade of the inhibitory effect of histamine on proliferation (34). Furthermore, histamine differentially regulated the expression and activity of matrix metalloproteinases, cell migration and invasiveness through H 2 R and H 4 R in MDA-MB-231 cells modulating H 2 O 2 intracellular levels (35). In addition, histamine decreased the proliferation of a more differentiated breast cancer cell line, MCF-7, through the stimulation of the four histamine receptor subtypes, exhibiting a higher effect through the H 4 R. Treatment of MCF-7 cells with H 4 R agonists induced an augment in the number of cells in the G0/G1 phase of the cell cycle and also exerted an anti-proliferative effect, augmenting the number of apoptotic and senescent cells (33) ( Table 2).…”

Section: Role Of Histamine H 4 Receptor In Biological Processes Assocmentioning

confidence: 99%

Histamine H4 receptor insights into a potential therapeutic target in breast cancer

Medina¹

2015

Front Biosci

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Breast cancer is the second most common cancer worldwide, and the leading cause of cancer death in women. Several studies underlined the critical role of histamine in breast cancer development and progression. This review addresses the latest evidence regarding the involvement of histamine and histamine receptors in breast cancer, focusing particularly in the histamine H4 receptor (H4R). Histamine concentration in breast cancer tissues was found to be higher than that in normal tissues of healthy controls by means of an increase in the activity of histidine decarboxylase (HDC), the enzyme involved in histamine production. The expression of H4R in different experimental models and human biopsies, the associated biological responses, as well as the in vivo treatment of experimental tumors with H4R ligands is reviewed. Evidence demonstrates that the H4R exhibits a key role in histamine-mediated biological processes such as cell proliferation, senescence and apoptosis in breast cancer. The polymorphisms of the H4R and HDC genes and their association with breast cancer risk and malignancy reinforce the critical (patho)physiological role of H4R in breast cancer. In addition, H4R agonists display anti-tumor effects in vivo in a triple negative breast cancer model. The findings support the exploitation of the H4R as a molecular target for breast cancer drug development.

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Histamine and Breast Cancer: A New Role for a Well Known Amine

Cited by 6 publications

References 73 publications

Histamine prevents radiation-induced mesenchymal changes in breast cancer cells

Histamine prevents radiation-induced mesenchymal changes in breast cancer cells

Therapeutic potential of histamine H₄ receptor agonists in triple‐negative human breast cancer experimental model

Histamine H4 receptor insights into a potential therapeutic target in breast cancer

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Histamine and Breast Cancer: A New Role for a Well Known Amine

Cited by 6 publications

References 73 publications

Histamine prevents radiation-induced mesenchymal changes in breast cancer cells

Histamine prevents radiation-induced mesenchymal changes in breast cancer cells

Therapeutic potential of histamine H4 receptor agonists in triple‐negative human breast cancer experimental model

Histamine H4 receptor insights into a potential therapeutic target in breast cancer

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Therapeutic potential of histamine H₄ receptor agonists in triple‐negative human breast cancer experimental model