Histamine Modulation of Neurotransmission in the Sympathetic Nervous System

Marshall, Ian

doi:10.1111/j.1474-8673.1981.tb00452.x

Cited by 14 publications

(3 citation statements)

References 90 publications

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“…Twitch responses of the mouse vas deferens can also be inhibited via opioid receptors (Hughes et al, 1975) and histamine H2-receptors (Marshall, 1981). Rat a-CGRP was equi-effective against responses to stimulation at 0.2 Hz and 1.0 Hz but less effective against responses of the vas deferens elicited by 10 Hz which is similar to histamine (Marshall, 1981), but different from M2-adrenoceptor or opioid agonists (Marshall et al, 1978a;1981). An additional characteristic of twitch inhibition of rat a-CGRP was its lack of dependence on the external calcium concentration.…”

Section: Discussionmentioning

confidence: 99%

“…An additional characteristic of twitch inhibition of rat a-CGRP was its lack of dependence on the external calcium concentration. This differentiates its action from that of M2-agonists (Marshall et al, 1980), opioids as well as from histamine (Marshall, 1981) where decreasing the calcium concentration leads to an increased effectiveness of the drug.…”

Section: Discussionmentioning

confidence: 99%

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Postjunctional inhibition of contractor responses in the mouse vas deferens by rat and human calcitonin gene‐related peptides (CGRP)

Al-Kazwini

Craig

Marshall

1986

British J Pharmacology

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3 The inhibitory effect of human ax-CGRP was not antagonized by either propranolol (300 nM) or idazoxan (300 nM), although in the same tissues these latter two drugs reduced responses to isoprenaline and clonidine respectively.4 Rat a-CGRP (100 nM) and human x-CGRP(1.0 yM) did not alter the uptake of[3H]-noradrenaline (30 nM) into mice isolated vasa deferentia. Rat a-CGRP (3-100 nM) did not alter the fractional release per pulse (1.0 Hz, 100 pulses) of tritium from vasa preloaded with [3H]-noradrenaline, although at the same time the peptide inhibited responses of the smooth muscle to field stimulation. 5 Rat and human a-CGRP were equipotent at inhibiting contractions of the mouse vas deferens evoked by acetylcholine although the peptides were less potent than against twitch responses. 6 In the rabbit vas deferens neither rat nor human a-CGRP (3 nM-I A1M) inhibited either twitch responses or acetylcholine contractions. 7 These results suggest that rat and human a-CGRP inhibit contractor responses of the mouse vas deferens not by interference with adrenergic mechanisms, but through postjunctional (possibly CGRP) receptors. A similar mechanism may underlie effects of CGRP in other tissues. The rabbit vas deferens appears to lack the CGRP 'receptors'.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Postjunctional inhibition of contractor responses in the mouse vas deferens by rat and human calcitonin gene‐related peptides (CGRP)

Al-Kazwini

Craig

Marshall

1986

British J Pharmacology

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“…Low histamine concentrations elicit facilitatory effects, and higher concentrations produce depressant effects in both the cat (Brezenoff & Gertner, 1972) and the bullfrog (Yamada, Tokimasa & Koketsu, 1982) SCG. These opposing effects of histamine have been attributed to activation of different histamine receptor subtypes (Marshall, 1981). Histamine-induced facilitation of synaptic transmission in sympathetic ganglia of several species has been demonstrated to be mediated via histamine Hi receptors (Trendelenberg, 1957;Brimble & Wallis, 1973;Yamada et al 1982;Lindl, 1983;Snow & Weinreich, 1987), and histamine-induced synaptic depression has been linked to H2 histamine receptor activation (Brimble & Wallis, 1973;Yamada et al 1982; Snow & Weinreich, 1987).…”

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Presynaptic histamine H1 and H3 receptors modulate sympathetic ganglionic synaptic transmission in the guinea‐pig.

Christian

Weinreich

1992

The Journal of Physiology

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SUMMARY1. To study the effects of histamine on the efficacy of sympathetic ganglionic synaptic transmission, extracellular recordings of the postganglionic compound action potential (CAP) and intracellular recordings of excitatory postsynaptic potentials (EPSPs) elicited by preganglionic electrical stimulation were obtained from isolated guinea-pig superior cervical ganglia (SCG).2. In different preparations, superfusion with histamine (0 1-100 /IM) either potentiated or depressed the postganglionic CAP elicited by electrical stimulation of the cervical sympathetic trunk (0-2-3-0 Hz). The direction of response produced by histamine did not depend on stimulation frequency or histamine concentration; potentiation and depression both showed concentration dependence over the range of histamine concentrations tested.3. Experiments employing a variety of histamine receptor agonists or antagonists revealed that histamine-induced potentiation of the postganglionic CAP could be attributed to histamine H1 receptor activation, and depression to H3 receptor activation.4. Histamine similarly potentiated or depressed the intracellularly recorded EPSP. However, these opposite effects occurred at different synapses. In agreement with the studies on the postganglionic CAP, histamine H1 antagonists prevented histamine-induced potentiation of the EPSP and H3 receptor antagonists prevented histamine-induced depression.5. Direct quantal analyses of histamine-induced synaptic potentiation and depression were implemented to determine the pre-and postsynaptic components of these effects. Quantal size was estimated by measuring the amplitude of spontaneous miniature EPSP amplitudes. Histamine-induced potentiation and depression of the evoked EPSP were found to be accompanied by increased or decreased quantal content respectively, and unchanged quantal size, providing evidence that presynaptic mechanisms were involved in mediating both effects.6. Some guinea-pigs were actively sensitized to ovalbumin. Subsequent exposure

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Histamine and Its Receptors in the Nervous System

Hough

Green

1984

Handbook of Neurochemistry

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Histamine Modulation of Neurotransmission in the Sympathetic Nervous System

Cited by 14 publications

References 90 publications

Postjunctional inhibition of contractor responses in the mouse vas deferens by rat and human calcitonin gene‐related peptides (CGRP)

Postjunctional inhibition of contractor responses in the mouse vas deferens by rat and human calcitonin gene‐related peptides (CGRP)

Presynaptic histamine H1 and H3 receptors modulate sympathetic ganglionic synaptic transmission in the guinea‐pig.

Histamine and Its Receptors in the Nervous System

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