Histamine and Its Receptors in the Nervous System

Histamine in the Human Eye

“…Numerous reports in the literature indi cate that histamine (HI) is present in differ ent amounts in nearly all tissues of the body, including the central nervous system of var ious animal species [1,2], Recently we have demonstrated HI presence in several ocular structures of some mammalian and non mammalian species [3][4][5]. The amine levels were found to be highly different depending on the part of the eye examined, with the lowest values always observed in the retina [4].…”

Distribution of Histamine-Containing Neurons in the Laboratory Shrew (Suncus murinus) Brain.

“…However, it was also clarified that a considerably smaller number of HIS-IR nerve fibers than that in rats were distributed to other hypothalamic nuclei of the shrew, where the number of the HIS-IR nerve fibers observed was relatively large. The histamine neuron system is considered to be involved in the control of fundamental physiological functions related to maintenance of life, such as falling asleep and awakening, moving, eating, drinking, neurosecretion, autonomic nervous system regulation, sense of equilibrium, pain sensation and maintenance of intracerebral glycogen level [2,3,23,24]. The type of shrew employed in this study, which belongs to Insectivora and was originally a wild animal, has been used as a laboratory animal in recent years.…”

“…Histamine (HIS), which is known to be involved in the control of various physiological functions such as falling asleep and awakening, moving, eating, and drinking [2,3,23,24], is distributed in tissues of most mammals including humans. In particular, the skin, lungs, digestive tract, and mucosa of mammals contain HIS at a high concentration.…”

Effect of acute treatment of mice with L-histidine on the brain levels of amino acids.

“…Histamine has been suggested to be a neurotransmitter in the mammalian brain (1,2). Histaminergic fibers originating from the cell bodies in the posterior hypothalamus are distributed in various parts of the brain (3, 4).…”