Histamine in Duodenal Ulcer, Stress-Induced Lesions, and Upper Gastrointestinal Bleeding: Causality Analysis

Sattler, J.; Lorenz, W.; Lindlar, R.; Schäfer, Ulrich

doi:10.1007/978-3-642-75840-9_22

Cited by 6 publications

(5 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Elevated histamine levels in body fluids have been found following polytrauma, in septic shock but also in standard surgical situations. Of interest in the present context, manual exploration of body cavities, in particular when peritoneal irritation is present, results in high levels of plasma histamine (24,25). In the latter case, concentrations in the same range as in systemic anaphylactoid reactions have been observed (24).…”

Section: Discussionmentioning

confidence: 82%

“…The arrythmogenic effects are potentiated following myocardial infarction (13). A marked release of histamine has been found after some anaesthetic agents, in surgical trauma, following allogenic blood transfusion or infusion of colloidal plasma substitutes and during extracorporeal circulation (23,24). Elevated histamine levels in body fluids have been found following polytrauma, in septic shock but also in standard surgical situations.…”

Section: Discussionmentioning

confidence: 99%

“…Of interest in the present context, manual exploration of body cavities, in particular when peritoneal irritation is present, results in high levels of plasma histamine (24,25). In the latter case, concentrations in the same range as in systemic anaphylactoid reactions have been observed (24). Major clinical studies to assess the efficacy of combined histamine receptor blockade have been carried out and the routine use of such blockade has been advocated (26).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Decrease in plasma volume from intra‐abdominal trauma in rats is prevented by H₁ but not by H₂ histaminergic blockade

Larmark¹,

Lisander

1996

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

Intra-abdominal surgery causes plasma extravasation which, in the rat, is prevented by combined histaminergic H1 and H2 blockade. We evaluated the relative importance of H1 and H2 blockade in this situation. Cloralose-anaesthetized Wistar rats were subjected to a standardized abdominal trauma. Mean arterial pressure (MAP), heart rate (HR) and haematocrit (Hct) were monitored and plasma volume (PV) was determined before and 1 h after the trauma. Compared to non-traumatized rats (n = 8), the trauma decreased PV and increased Hct (n = 8). MAP decreased during the actual trauma, whereas HR remained stable throughout. In animals given cimetidine 25 mg kg-1 i.v. just prior to the trauma (n = 8), PV, Hct and MAP changed, as in the non-blocked rats. In contrast, pyrilamine, 10 mg kg-1, completely prevented the decrease in PV and the increase in Hct (n = 7), but not the decrease in MAP. The findings suggest that a histaminergic H1 mechanism is of importance for the plasma loss elicited by intra-abdominal trauma.

show abstract

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Decrease in plasma volume from intra‐abdominal trauma in rats is prevented by H₁ but not by H₂ histaminergic blockade

Larmark¹,

Lisander

1996

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

show abstract

“…If histamine in food or other sources (e.g. blood in the gut following gastrointestinal bleeding [26] or bacterial overgrowth, which might convert histidine in food to histamine) [3] is not adequately metabolised its concentration rises within the lumen and can subsequently be resorbed leading to elevated plasma histamine levels [3]. Besides drugs other factors like alcohol or gastrointestinal diseases have also been demonstrated to inhibit histamine metabolism [3].…”

Section: Lowered Levels Of Enzymes Which Metabolise Histaminementioning

confidence: 99%

Enteral histaminosis: Clinical implications

Amon¹,

Bangha²,

Kuster³

et al. 1999

Inflamm. res.

View full text Add to dashboard Cite

There is increasing evidence that enteral histaminosis is a major cause of food intolerance resulting from dysfunctional metabolism of endogenous histamine in certain food stuffs. However, this phenomenon has been poorly characterised and, due to the lack of epidemiological data, the existence of this condition has been underestimated, which may lead to incorrect diagnosis. This short commentary highlights a stricter regimen of diagnostic procedure in order to take into account the many causes of food intolerance. The underlying mechanisms ascribed particularly to non-immunologically food reactions require more rigorous research and further work is vital.

show abstract

“…[73] en, wenn vorhanden, aber auch retrospektive Studien oder die für die Studie sorgfältig durchgeführte Analyse des Krankenguts der eigenen Klinik, wofür wir in der Ulkuschirurgie ein Beispiel geliefert haben [45]. [73] en, wenn vorhanden, aber auch retrospektive Studien oder die für die Studie sorgfältig durchgeführte Analyse des Krankenguts der eigenen Klinik, wofür wir in der Ulkuschirurgie ein Beispiel geliefert haben [45].…”

Section: Studien Zur Entscheidungsanalyseunclassified

Klinische Studien in der Notfallmedizin

et al. 1998

Self Cite

View full text Add to dashboard Cite

Clinical studies are usually conceived of as controlled randomized trials, as retrospective patient statistics or as single case reports. However, such a classification is too narrow and overlooks many other forms of study designs. This review, therefore, offers a more encompassing and practical classification of clinical studies for the field of emergency medicine. Randomized controlled trials fulfill scientific criteria at the highest level (gold standard): comparison, repeatability, objective measurement. At the same time, randomized trials also have to comply with demanding ethical criteria and must be justifiable in the individual patient. Therefore, comparable uncertainty with regard to the superiority of the treatment options under investigation is a sine qua non. In addition to randomized trials, six other groups of clinical trials have the potential to solve scientific questions in emergency medicine: observational studies, decision analysis, meta analysis, public health care studies, case reports and descriptive summary statistics and studies on ethical problems. This variability in trial designs calls for a clinically oriented methodologist; the concept and institutionalization of theoretical surgery has been a response to this demand. All study types in this review are illustrated by examples in emergency medicine. Literature for advanced reading in particular trial methodologies can be found in the reference list. A checklist summarizes all elements for designing and conducting randomized trials in emergency medicine. All clinical trials striving for a high standard of quality--whether randomized or not--depend on the following prerequisites:professional organization, time effort, a supportive social environment and a scientific culture.

show abstract

Histamine in Duodenal Ulcer, Stress-Induced Lesions, and Upper Gastrointestinal Bleeding: Causality Analysis

Cited by 6 publications

References 56 publications

Decrease in plasma volume from intra‐abdominal trauma in rats is prevented by H₁ but not by H₂ histaminergic blockade

Decrease in plasma volume from intra‐abdominal trauma in rats is prevented by H₁ but not by H₂ histaminergic blockade

Enteral histaminosis: Clinical implications

Klinische Studien in der Notfallmedizin

Contact Info

Product

Resources

About

Histamine in Duodenal Ulcer, Stress-Induced Lesions, and Upper Gastrointestinal Bleeding: Causality Analysis

Cited by 6 publications

References 56 publications

Decrease in plasma volume from intra‐abdominal trauma in rats is prevented by H1 but not by H2 histaminergic blockade

Decrease in plasma volume from intra‐abdominal trauma in rats is prevented by H1 but not by H2 histaminergic blockade

Enteral histaminosis: Clinical implications

Klinische Studien in der Notfallmedizin

Contact Info

Product

Resources

About

Decrease in plasma volume from intra‐abdominal trauma in rats is prevented by H₁ but not by H₂ histaminergic blockade

Decrease in plasma volume from intra‐abdominal trauma in rats is prevented by H₁ but not by H₂ histaminergic blockade