Histamine and its derivatives in human urine

Kapeller‐Adler, R.; Iggo, Betty

doi:10.1016/0006-3002(57)90484-5

Cited by 53 publications

(6 citation statements)

References 15 publications

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“…The fact that the activity was antagonized by antihistamine and almost completely inactivated by diamine oxidase makes this assumption unlikely. The bioactive side-chain Nmethylhistamines are, e.g., not inactivated by histaminase (9).…”

Section: Discussionmentioning

confidence: 99%

Histamine Formation after Oral L‐histidine in Health and Dystrophia Myotonica

Sjaastad¹

1966

Journal of Internal Medicine

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Section: Discussionmentioning

confidence: 99%

Histamine Formation after Oral L‐histidine in Health and Dystrophia Myotonica

Sjaastad¹

1966

Journal of Internal Medicine

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“…It is not known whether the gastric mucosa contains an enzyme system which can methylate histamine at the side chain and if so whether it is the same enzyme which methylates the imidazole ring. Side-chain-methylated histamine derivatives were found in the gastric mucosa o f dogs treated with :4C-histamine (13), the gastric mucosa o f guinea pigs treated with cortisone (11), the gastric mucosa and juice of the isolated canine stomach (4,5), and human urine (9). These reports coming from three different groups would favor the view that in some experi mental animals and man side-chain-methylated histamine derivatives are most likely to occur in the gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

Methylation of Histamine in the Gastric Mucosa

Maśliński¹,

Schippert²,

Kovar³

et al. 1977

Digestion

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Methylation of histamine in the gastric mucosa of various species has been studied in vitro and in vivo. When gastric mucosal homogenates of rat, guinea pig, cat, dog, and pig were incubated with ¹⁴C-histamine in the presence of S-adenosyl methionine N^>τ-methylhistamine was formed as the only methylated histamine derivative. Excessive concentration of N^τ-methylhistamine inhibited the formation of N^τ-methylhistamine. Pretreatment of guinea pigs with prednisolone, aminoguanidine, or pentagastrin neither influenced in vitro the formation of N^τ-methylhistamine significantly nor shifted the methylation reaction towards the side chain. Pretreatment of guinea pigs with the histamine H₂-receptor blocker cimetidine significantly enhanced the formation of N^τ-methylhistamine in vitro. In pooled samples of guinea pig gastric mucosa histamine and N^τ-methylhistamine were found. Under none of these circumstances was N^α-methyl-orN^α, N^α-dimethylhistamine found. It is concluded that in rat (to a small extent), guinea pig, cat, dog, and pig gastric mucosa the formation of N^τ-methylhistamine is the only methylating pathway of histamine. In cases where other methylated histamine derivatives (N°-methyl- and/or N^α, N^α-dimethylhistamine) are found they must origin in sources other than the gastric mucosa.

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“…In 1970, Kovacs and Heisler (11) reported the occurrence of N" -methylated histamine derivatives in the gastric mucosa in guinea pigs after treatment with the diamine oxidase inhibitor aminoguanidine and cortisone which was alleged to stimulate the side chain methylation. These authors mainly followed the method of Kapeller-Adler and Iggo (9), who in 1957 for the first time dis covered side chain methylated histamine deriva tives in human urine. These compounds were identified after an isolation on a basic ion-ex change column (Decalso®) on a paper chro matogram.…”

Section: Discussionmentioning

confidence: 99%

Determination of Histamine and Its Metabolic Products in the Pig Gastric Mucosa

Schippert¹,

Kovar²,

Sewing³

1979

Pharmacology

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This paper describes analytical techniques for quantitative and qualitative determination of histamine and its metabolites (N^τ-methylhistamine, N^α-methylhistamine and N^α, N^α-dimethylhistamine) in the pig gastric mucosa. These metabolites and N^α-acetylhistamine, imidazolyl-4-acetic acid and N^τ-methylimidazolylacetic acid were synthesized as reference compounds and analyzed by using the dansylation technique. TLC of dansylated mucosal extracts in various solvents {in situ fluorescence measurements) in combination with TLC/IR and TLC/MS transfer technique demonstrated the presence of histamine. The only metabolite was N^τ-methyl-histamine.

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Histamine and its derivatives in human urine

Cited by 53 publications

References 15 publications

Histamine Formation after Oral L‐histidine in Health and Dystrophia Myotonica

Histamine Formation after Oral L‐histidine in Health and Dystrophia Myotonica

Methylation of Histamine in the Gastric Mucosa

Determination of Histamine and Its Metabolic Products in the Pig Gastric Mucosa

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