Histamine and gastric acid secretion in rabbits: Mechanism of inhibition

Stajniak, A.; Pruszyński, J. P.; Maśliński, S

doi:10.1007/bf01965138

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1982

DOI: 10.1007/bf01965138

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Histamine and gastric acid secretion in rabbits: Mechanism of inhibition

A. Stajniak¹,

J. P. Pruszyński²,

S Maśliński³

Abstract: Supramaximal doses of histamine inhibit gastric acid secretion in rabbits. Mepyramine partially blocks this action of histamine. Catecholamine concentrations in the gastric mucosa are not changed during infusion of histamine. It is concluded that in rabbits the inhibitory effect of histamine on acid secretion is not connected with a change in local catecholamine content.

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1990

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Histamine Stimulation of Mucociliary Activity in the Rabbit Maxillary Sinus

Dolata¹,

Lindberg²,

Mercke³

1990

Ann Otol Rhinol Laryngol

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The in vivo effect of histamine on mucociliary activity in the rabbit maxillary sinus was investigated by injecting histamine into the maxillary artery and recording the responses with a photoelectric technique. Histamine stimulated the mucociliary activity dose-dependently in the dose range 10 to 1,000 micrograms/kg. The maximum response was 31.6% +/- 3.7% at a dose of 50 micrograms/kg. The histamine-induced stimulation of the mucociliary activity was characterized by a short latency with a peak response within 1 to 2 minutes and a slow decline lasting about 5 minutes. The response displayed tachyphylaxis. Cholinergic blockade with atropine did not affect the response to histamine. Blockade of H1 receptors with pyrilamine abolished the response to histamine, whereas blockade of H2 receptors with cimetidine was without effect. The H2 agonist dimaprit failed to stimulate the mucociliary activity. It is concluded that histamine stimulates the mucociliary activity in the rabbit maxillary sinus via H1 receptors.

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Histamine Stimulation of Mucociliary Activity in the Rabbit Maxillary Sinus

Dolata¹,

Lindberg²,

Mercke³

1990

Ann Otol Rhinol Laryngol

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show abstract

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Histamine and gastric acid secretion in rabbits: Mechanism of inhibition

Cited by 1 publication

References 6 publications

Histamine Stimulation of Mucociliary Activity in the Rabbit Maxillary Sinus

Histamine Stimulation of Mucociliary Activity in the Rabbit Maxillary Sinus

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