Hippocampal volume in patients with bilateral and unilateral peripheral vestibular dysfunction

Schöne, Corina G.; Rebsamen, Michael; Wyssen, Gerda; Rummel, Christian; Wagner, Franca; Vibert, Dominique; Mast, Fred W.

doi:10.1016/j.nicl.2022.103212

Cited by 9 publications

(16 citation statements)

References 40 publications

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“…This study included 15 patients with disease duration ranging from 9 months to 23 years. These findings are supported by Schöne et al (2022) who analysed structural changes in the brain, including the hippocampus, in 55 patients with peripheral vestibular dysfunction, of which 19 demonstrated bilateral vestibular loss (age: 53.18 ± 19 years; disease duration: 14.68 ± 13.29 years). They also observed a lack of hippocampal volume loss compared to age- and sex-matched healthy controls.…”

Section: Introductionmentioning

confidence: 68%

“…As such, positive studies by Brandt et al (2005) and Kremmyda et al (2016) are often cited exclusively to substantiate this hypothesis. However, the role of the replication crisis should not be underestimated and these current null findings, together with those observed by Dordevic et al (2021), Gottlich et al (2016), and Schöne et al (2022) need to be taken into account to correct earlier underpowered findings using less reliable segmentation approaches to avoid future false understandings of this association. However, one can question whether the present study’s negative results can completely disprove the association between hippocampal atrophy and BV?…”

Section: Discussionmentioning

confidence: 97%

“…They also observed a lack of hippocampal volume loss compared to age-and sex-matched healthy controls. Overall, studies evaluating hippocampal volume in bilateral vestibular loss have yielded contradicting results, with some studies from one lab observing a decrease in hippocampal volume (Brandt et al, 2005;Kremmyda et al, 2016) while other multi-site studies do not (Dordevic et al, 2021;Gottlich et al, 2016;Schöne et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

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Is vestibular function related to human hippocampal volume?

Bosmans

Gommeren

Eulenburg³

et al. 2023

Preprint

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INTRODUCTION: Recent studies implicate the effect of vestibular loss on cognitive decline, including hippocampal volume loss. As hippocampal atrophy is an important biomarker of Alzheimer′s disease, exploring vestibular dysfunction as a risk factor for dementia and its role in hippocampal atrophy is of interest. METHODS: Hippocampal and whole-brain MRI volumes were compared in adults aged between 55 and 83 years: (1) to substantiate previous literature, bilateral vestibulopathy (BV) was compared to healthy controls, (2) to correct for a potential confounding effect of concomitant hearing loss, BV was compared to healthy controls matched on age, sex, and hearing status, (3) to additionally evaluate the isolated effect of hearing loss on brain structure, sensorineural hearing loss (SNHL) was compared to healthy controls. Furthermore, to delineate otolith influence on hippocampal volume in preserved vestibular function (healthy controls and SNHL combined), saccular function was investigated. RESULTS: Whole-brain and targeted hippocampal approaches using volumetric and surface-based measures yielded no significant differences in either of three comparisons: (1) BV versus controls, (2) BV versus matched controls, and (3) SNHL versus controls. Binary support vector machines were unable to classify inner ear health status above chance level. Otolith parameters were significantly associated with hippocampal volume in preserved vestibular function. CONCLUSION: No significant differences in whole-brain or hippocampal volume were found when comparing BV with healthy controls, nor did concomitant SNHL confound this relationship. Otolith function may be associated with hippocampal volume rather than lateral semicircular canal integrity. Future BV studies should generally incorporate otolith function testing.

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Section: Introductionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is vestibular function related to human hippocampal volume?

Bosmans

Gommeren

Eulenburg³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Structural MRI analysis, through volumetric measurements, also can help to understand the role of multiple brain areas have in the vestibular cognition and how it can relate with dementia. Schöne et al (2022) , compared hippocampal volume, as well as supramarginal, superior temporal and postcentral gyrus in a sample of 55 patients with different conditions of peripheral vestibular dysfunction to 39 age and sex matched healthy controls. Correlations between morphometric data and visuo-spatial performance were analyzed too.…”

Section: Methodsmentioning

confidence: 99%

“…Contrary to bilateral vestibular dysfunction, chronic and acute unilateral vestibular dysfunction were associated with reduced brain volumes in the right presubiculum of the hippocampus and the left supramarginal gyrus. Unilateral peripheral vestibular dysfunction might lead to reduced central brain volumes that are involved in the processing of vestibular information ( Schöne et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Vestibular dysfunction and its association with cognitive impairment and dementia

Aedo-Sanchez,

Riquelme-Contreras,

Henríquez

et al. 2024

Front. Neurosci.

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The vestibular system plays an important role in maintaining balance and posture. It also contributes to vertical perception, body awareness and spatial navigation. In addition to its sensory function, the vestibular system has direct connections to key areas responsible for higher cognitive functions, such as the prefrontal cortex, insula and hippocampus. Several studies have reported that vestibular dysfunction, in particular bilateral vestibulopathy, is associated with an increased risk of cognitive impairment and the development of dementias such as Alzheimer’s disease. However, it is still controversial whether there is a causal relationship between vestibular damage and cognitive dysfunction. In this mini-review, we will explore the relationship between the vestibular system, cognitive dysfunction and dementia, hypotheses about the hypothesis and causes that may explain this phenomenon and also some potential confounders that may also lead to cognitive impairment. We will also review multimodal neuroimaging approaches that have investigated structural and functional effects on the cortico-vestibular network and finally, describe some approaches to the management of patients with vestibular damage who have shown some cognitive impairment.

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Effect of Late‐Stage Meniere's Disease and Vestibular Functional Impairment on Hippocampal Atrophy

Jian

Wang

et al. 2023

The Laryngoscope

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ObjectiveWe investigated correlations among clinical features, degree of inner ear endolymphatic hydrops (EH), and hippocampal volume (HV) in different stages of Meniere's disease (MD).MethodsFrom February 2021 to April 2022, clinical data were collected from 99 patients (39 males, 60 females, mean age: 50.4 ± 10.0 [range: 26–69] years) with unilateral MD admitted to the Department of Vertigo Disease of Shandong ENT Hospital. The left and right ears were affected in 64 and 35 patients, respectively. There were 50 and 49 cases in early (Stages 1, 2) and late stages (Stages 3, 4), respectively. Fifty healthy participants were included as controls. Audiovestibular function test results, EH grading using gadolinium‐enhanced magnetic resonance imaging (MRI), and HV determined on MRI were analyzed for patients at different stages of MD.ResultsBetween‐group comparisons of early and late MD revealed significant differences in the disease course, vestibular function (VF), degree of EH, and HV. There were no significant between‐group differences based on age, sex, affected side, subjective degree of dizziness, hospital anxiety, or depression. Mean HV in patients with early‐stage MD was correlated with the canal paresis value of the caloric test and pure tone hearing threshold, HV in late‐stage patients was correlated with vestibular EH.ConclusionPatients with late‐stage MD exhibited severe auditory and VF impairments, increased EH, and atrophy of the HV. More advanced disease was associated with greater vestibular damage and degree of EH.Level of Evidence3 Laryngoscope, 2023

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Hippocampal volume in patients with bilateral and unilateral peripheral vestibular dysfunction

Cited by 9 publications

References 40 publications

Is vestibular function related to human hippocampal volume?

Is vestibular function related to human hippocampal volume?

Vestibular dysfunction and its association with cognitive impairment and dementia

Effect of Late‐Stage Meniere's Disease and Vestibular Functional Impairment on Hippocampal Atrophy

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