Hippocampal subfield volumes in children and adolescents with mood disorders

Tannous, Jonika; Amaral-Silva, Henrique; Cao, Bo; Wu, Mon Ju; Zunta-Soares, Giovana; Kazimi, Iram; Zeni, Cristian Patrick; Mwangi, Benson; Soares, Jair C.

doi:10.1016/j.jpsychires.2018.03.003

Cited by 51 publications

(22 citation statements)

References 52 publications

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“…17 Yao et al found that the ReHo values of BD patients were significantly different from healthy subjects in the right hippocampus, right amygdala, right parahippocampal gyrus, and right orbital inferior frontal gyrus 5 Tannous et al reported that patients with UD and BD exhibited decreased gray matter volume (GMV) in the hippocampus and parahippocampal gyrus which have a significant impact on executive function, stress regulation and learning processes. 18 The hippocampus located below the cerebral cortex and inside the temporal lobe contains the hippocampus proper and the dentate gyrus. As a component of the limbic system, the hippocampus plays an important role in learning, memory, spatial orientation, and emotional management.…”

Section: Discussionmentioning

confidence: 99%

<p>Similar and Different Regional Homogeneity Changes Between Bipolar Disorder and Unipolar Depression: A Resting-State fMRI Study</p>

Liu¹,

Li²,

Zhang³

et al. 2020

NDT

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Objective: To investigate the regional homogeneity (ReHo) between unipolar depression (UD) and bipolar disorder (BD), and to search for brain imaging markers for distinguishing UD and BD. Methods: A total of 58 patients who met the diagnosis criteria of UD in DSM-Ⅳ, 40 patients who met the diagnosis criteria of BD in DSM-Ⅳ and 54 healthy controls (HC) completed the resting-state functional magnetic resonance (rs-fMRI) scans. The ReHo of the three groups was compared and Pearson correlation analysis was performed between the ReHo values and the clinical symptoms. Results: (1) Significant differences were found in the right hippocampus, right parahippocampal gyrus, right Inferior orbitofrontal gyrus, right superior temporal gyrus, right inferior temporal gyrus, and right middle occipital gyrus across the three groups. (2) Compared to HC, the ReHo in the right parahippocampal gyrus in UD significantly increased. (3) When compared to HC, the ReHo in the right hippocampus in BD significantly increased. The ReHo in the right middle occipital gyrus decreased. (4) Compared to UD, BD exhibited significantly decreased ReHo in the right inferior temporal gyrus. No correlations were observed between the scores of 24-item Hamilton Depression Rating Scale (HDMD-24), Hamilton Anxiety Scale (HAMA), Young Mania Rating Scale (YMRS), and the ReHo values of altered brain regions between BD and UD. Conclusion: The results suggest that there was a considerable difference in the ReHo of brain among UD, BD, and HCs. ReHo in the right inferior temporal gyrus showed significant differences between BD and UD that might serve as neuroimaging markers to identify BD and UD.

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Section: Discussionmentioning

confidence: 99%

<p>Similar and Different Regional Homogeneity Changes Between Bipolar Disorder and Unipolar Depression: A Resting-State fMRI Study</p>

Liu¹,

Li²,

Zhang³

et al. 2020

NDT

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“…Indeed, the hippocampus, a subcortical structure critically involved in memory and cognition, has been shown to be sensitive to stress and smaller hippocampal volumes are characteristic of various mood disorders, including MDD [11][12][13] . Although global hippocampal volume may differ between populations, the hippocampus is in fact made up of anatomically and functionally distinct subfields that may be differentially sensitive to stressors and play varying roles in mood disorder pathophysiology 14 . Therefore, investigating whether specific subfields are linked to MDD may serve to provide greater clarity as to the mechanisms behind the disease 15 .…”

Section: Introductionmentioning

confidence: 99%

Stress, inflammation and hippocampal subfields in depression: A 7 Tesla MRI Study

et al. 2020

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Experiencing stressful events throughout one's life, particularly childhood trauma, increases the likelihood of being diagnosed with Major Depressive Disorder (MDD). Raised levels of cortisol, and markers of inflammation such as Interleukin (IL-6) and C-reactive protein (CRP), have been linked to both early life stress and MDD. We aimed to explore the biological stress signatures of early stress and MDD on hippocampal sub regional volumes using 7 Tesla MRI imaging. A cohort of 71 MDD patients was compared against 46 age and sex-matched healthy volunteers. MDD subjects had higher averages of IL-6 and CRP levels. These differences were significant for IL-6 levels and trended for CRP. There were no significant group differences in any of the hippocampal subfields or global hippocampal volumes; further, there were no hippocampal subfield differences between MDD subjects with high levels of our biological stress measures and MDDs with normal levels.

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“…These subfields include the cornu ammonis fields (CA1, CA2, CA3, and CA4), the dentate gyrus (DG), and the subiculum (Duvernoy, ). Some prior research has found that subfields are differentially associated with AD and mild cognitive impairment (La Joie et al, ; Mueller et al, ; Wolk et al, ; Yassa et al, ), schizophrenia and bipolar disorder (Baglivo et al, ; Cao et al, ; Haukvik et al, ; Ho et al, ; Mathew et al, ; Tannous et al, ), PTSD (Wang et al, ), and normal aging (Krogsrud et al, ; Yassa, Mattfeld, Stark, & Stark, ). Twin studies have shown that hippocampal volume is under significant genetic influence, with estimates of heritability ranging from 45 to 64% (Blokland, de Zubicaray, McMahon, & Wright, ; Kremen et al, ).…”

Section: Introductionmentioning

confidence: 99%

Genetic architecture of hippocampal subfields on standard resolution MRI: How the parts relate to the whole

Elman

Panizzon

Gillespie

et al. 2018

Human Brain Mapping

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The human hippocampus can be subdivided into subfields with unique functional properties and differential vulnerability to disease or neuropsychiatric conditions. Identifying genes that confer susceptibility to such processes is an important goal in developing treatments. Recent advances in automatic subfield segmentation from magnetic resonance images make it possible to use these measures as phenotypes in large-scale genome-wide association studies. Such analyses are likely to rely largely on standard resolution (~1 mm isotropic) T 1 -weighted images acquired on 3.0T scanners. Determining whether the genetic architecture of subfields can be detected from such images is therefore an important step. We used Freesurfer v6.0 to segment hippocampal subfields in two large twin studies, the Vietnam Era Twin Study of Aging and the Human Connectome Project. We estimated heritability of subfields and the genetic overlap with total hippocampal volume. Heritability was similar across samples, but little genetic variance remained after accounting for genetic influences on total hippocampal volume. Importantly, we examined genetic relationships between subfields to determine whether subfields can be grouped based on a smaller number of underlying, genetically independent factors. We identified three genetic factors in both samples, but the high degree of cross loadings precluded formation of genetically distinct groupings of subfields. These results confirm the reliability of Freesurfer v6.0 generated subfields across samples for phenotypic analyses. However, the current results suggest that it will be difficult for large-scale genetic analyses to identify subfield-specific genes that are distinct from both total hippocampal volume and other subfields using segmentations generated from standard resolution T 1 -weighted images.

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Hippocampal subfield volumes in children and adolescents with mood disorders

Cited by 51 publications

References 52 publications

<p>Similar and Different Regional Homogeneity Changes Between Bipolar Disorder and Unipolar Depression: A Resting-State fMRI Study</p>

<p>Similar and Different Regional Homogeneity Changes Between Bipolar Disorder and Unipolar Depression: A Resting-State fMRI Study</p>

Stress, inflammation and hippocampal subfields in depression: A 7 Tesla MRI Study

Genetic architecture of hippocampal subfields on standard resolution MRI: How the parts relate to the whole

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