Stress, inflammation and hippocampal subfields in depression: A 7 Tesla MRI Study

Tannous, Jonika; Godlewska, Beata R.; Tirumalaraju, Vaishali; Soares, Jair C.; Cowen, Philip J.; Selvaraj, Sudhakar

doi:10.1038/s41398-020-0759-0

Cited by 24 publications

(13 citation statements)

References 44 publications

(50 reference statements)

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“…One factor that might explain why our BD patients revealed no major hippocampal volume reductions is that, differently from ours, their cohort was heterogeneous, and not characterized by a predominantly depressive subtype. Our results, however, support the findings from a recent investigation showing no smaller volumes in MDD patients via high-resolution 7-Tesla MRI (Tannous et al, 2020 ). As in this study only HippSub volumes and not shape alterations were assessed, therefore we cannot identify if HippSub deformations coinciding with unaltered volumes were seen, as has been reported in MDD (Ballmaier et al, 2008 ; Cole et al, 2010 ).…”

Section: Discussionsupporting

confidence: 91%

Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline

Hansen

Singh

Bartels³

et al. 2021

Front. Aging Neurosci.

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Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases.Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups.Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and mood disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode.Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BD, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups.

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Section: Discussionsupporting

confidence: 91%

Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline

Hansen

Singh

Bartels³

et al. 2021

Front. Aging Neurosci.

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“…CA, Cornu ammonis; DG, dentate gyrus; SUB, subiculum; Tail, hippocampal tail; ERC, entorhinal cortex. For segmentation display, please see https://www.nitrc.org/projects/ashs 1.5T or 3T MRI, with four studies (9%) using high-field 7T MRI (Brown et al, 2019;Kraus et al, 2019;Tannous et al, 2020;Wisse et al, 2015).…”

Section: Systematic Review Resultsmentioning

confidence: 99%

Psychosocial factors and hippocampal subfields: The Medea‐7T study

Twait

Blom

Koek

et al. 2022

Human Brain Mapping

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Specific subfields within the hippocampus have shown vulnerability to chronic stress, highlighting the importance of looking regionally within the hippocampus to understand the role of psychosocial factors in the development of neurodegenerative diseases. A systematic review on psychosocial factors and hippocampal subfield volumes was performed and showed inconsistent results, highlighting the need for future studies to explore this relationship. The current study aimed to explore the association of psychosocial factors with hippocampal (subfield) volumes, using high‐field 7T MRI. Data were from the Memory Depression and Aging (Medea)‐7T study, which included 333 participants without dementia. Hippocampal subfields were automatically segmented from T2‐weighted images using ASHS software. Generalized linear models accounting for correlated outcomes were used to assess the association between subfields (i.e., entorhinal cortex, subiculum, Cornu Ammonis [CA]1, CA2, CA3, dentate gyrus, and tail) and each psychosocial factor (i.e., depressive symptoms, anxiety symptoms, childhood maltreatment, recent stressful life events, and social support), adjusted for age, sex, and intracranial volume. Neither depression nor anxiety was associated with specific hippocampal (subfield) volumes. A trend for lower total hippocampal volume was found in those reporting childhood maltreatment, and a trend for higher total hippocampal volume was found in those who experienced a recent stressful life event. Among subfields, low social support was associated with lower volume in the CA3 (B = −0.43, 95% CI: −0.72; −0.15). This study suggests possible differential effects among hippocampal (subfield) volumes and psychosocial factors.

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“…23 A large sample study showed a larger hippocampal tail in patients with MDD than in healthy controls, 20 and a 7 T MRI study failed to detect any volume abnormalities in hippocampal subfields. 71 These inconsistencies in the results may be because of the heterogeneity inherent in mood disorders (related to illness duration and treatment effects) probably along with less robust and more limited findings of hippocampal alterations in patients with MDD. Greater hippocampal atrophy in the parasubiculum and HATA in patients with schizophrenia relative to patients with MDD may contribute to the distinct clinical presentations associated with the 2 disorders.…”

Section: E45mentioning

confidence: 99%

Hippocampal subfield alterations in schizophrenia and major depressive disorder: a systematic review and network meta-analysis of anatomic MRI studies

Sun

Wang

et al. 2023

jpn

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Background: Hippocampal disturbances are important in the pathophysiology of both schizophrenia and major depressive disorder (MDD). Imaging studies have shown selective volume deficits across hippocampal subfields in both disorders. We aimed to investigate whether these volumetric alterations in hippocampal subfields are shared or divergent across disorders. Methods: We searched PubMed and Embase from database inception to May 8, 2021. We identified MRI studies in patients with schizophrenia, MDD or both, in which hippocampal subfield volumes were measured. We excluded nonoriginal, animal or postmortem studies, and studies that used other imaging modalities or overlapping data. We conducted a network meta-analysis to estimate and contrast alterations in subfield volumes in the 2 disorders. Results: We identified 45 studies that met the initial criteria for systematic review, of which 15 were eligible for network metaanalysis. Compared to healthy controls, patients with schizophrenia had reduced volumes in the bilateral cornu ammonis (CA) 1, granule cell layer of the dentate gyrus, subiculum, parasubiculum, molecular layer, hippocampal tail and hippocampus-amygdala transition area (HATA); in the left CA4 and presubiculum; and in the right fimbria. Patients with MDD had decreased volumes in the left CA3 and CA4 and increased volumes in the right HATA compared to healthy controls. The bilateral parasubiculum and right HATA were smaller in patients with schizophrenia than in patients with MDD. Limitations: We did not investigate medication effects because of limited information. Study heterogeneity was noteworthy in direct comparisons between patients with MDD and healthy controls. Conclusion: The volumes of multiple hippocampal subfields are selectively altered in patients with schizophrenia and MDD, with overlap and differentiation in subfield alterations across disorders. Rigorous head-to-head studies are needed to validate our findings.

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Stress, inflammation and hippocampal subfields in depression: A 7 Tesla MRI Study

Cited by 24 publications

References 44 publications

Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline

Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline

Psychosocial factors and hippocampal subfields: The Medea‐7T study

Hippocampal subfield alterations in schizophrenia and major depressive disorder: a systematic review and network meta-analysis of anatomic MRI studies

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