Hippocampal structure and human cognition: Key role of spatial processing and evidence supporting the efficiency hypothesis in females

Colom, Roberto; Stein, Jason L.; Rajagopalan, Priya; Martínez, Kenia; Hermel, David J.; Wang, Yalin; Álvarez‐Linera, Juan; Burgaleta, Miguel; Quiroga, Macarena Ángel; Shih, Pei Chun; Thompson, Paul M.

doi:10.1016/j.intell.2013.01.002

Cited by 40 publications

(27 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subcortical structures were not considered, but there are some studies showing a relevant role of these brain structures regarding the interaction between cognition and the sex variable. Thus, for instance, Colom et al (2013) applied a method for automated segmentation of the hippocampus finding significant relationships with general intelligence (g), abstract reasoning, and spatial processing. These correlations were positive for men but negative for women, suggesting higher efficiency in women.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in neocortical structure and cognitive performance: A surface-based morphometry study

et al. 2015

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Sex differences in neocortical structure and cognitive performance: A surface-based morphometry study

et al. 2015

Self Cite

View full text Add to dashboard Cite

“…These were preserved in the sample to provide a representative picture of the available literature. Note, however, that four of the effect sizes presented as zero in Table 1 were actually due to equal performance in females and males (Colom et al, 2013;De Luca et al, 2003;Krinzinger et al, 2012;León et al, 2014).…”

Section: Measure Level Variablesmentioning

confidence: 95%

Sex differences in visual-spatial working memory: A meta-analysis

2016

View full text Add to dashboard Cite

Visual-spatial working memory measures are widely used in clinical and experimental settings. Furthermore, it has been argued that the male advantage in spatial abilities can be explained by a sex difference in visual-spatial working memory. Therefore, sex differences in visual-spatial working memory have important implication for research, theory, and practice, but they have yet to be quantified. The present metaanalysis quantified the magnitude of sex differences in visualspatial working memory and examined variables that might moderate them. The analysis used a set of 180 effect sizes from healthy males and females drawn from 98 samples ranging in mean age from 3 to 86 years. Multilevel meta-analysis was used on the overall data set to account for nonindependent effect sizes. The data also were analyzed in separate task subgroups by means of multilevel and mixed-effects models. Results showed a small but significant male advantage (mean d = 0.155, 95 % confidence interval = 0.087-0.223). All the tasks produced a male advantage, except for memory for location, where a female advantage emerged. Age of the participants was a significant moderator, indicating that sex differences in visual-spatial working memory appeared first in the 13-17 years age group. Removing memory for location tasks from the sample affected the pattern of significant moderators. The present results indicate a male advantage in visual-spatial working memory, although age and specific task modulate the magnitude and direction of the effects. Implications for clinical applications, cognitive model building, and experimental research are discussed.

show abstract

“…Our surface smoothing process consists of mesh simplification using “progressive meshes” (Hoppe, 1996) and mesh refinement by Loop subdivision surface (Loop, 1987). The similar procedures were frequently adopted in a number of our prior works (Colom et al, 2013; Luders et al, 2013; Monje et al, 2013; Shi et al, 2014; Shi et al, 2013a; Shi et al, 2013b; Wang et al, 2011; Wang et al, 2010) and our experience showed that the smoothed meshes are accurate approximations to the original surfaces with higher signal-to-noise ratio (SNR) (Shi et al, 2013a). …”

Section: Methodsmentioning

confidence: 99%

Studying ventricular abnormalities in mild cognitive impairment with hyperbolic Ricci flow and tensor-based morphometry

et al. 2015

Self Cite

View full text Add to dashboard Cite

Mild Cognitive Impairment (MCI) is a transitional stage between normal aging and dementia and people with MCI are at high risk of progression to dementia. MCI is attracting increasing attention, as it offers an opportunity to target the disease process during an early symptomatic stage. Structural magnetic resonance imaging (MRI) measures have been the mainstay of Alzheimer’s disease (AD) imaging research, however, ventricular morphometry analysis remains challenging because of its complicated topological structure. Here we describe a novel ventricular morphometry system based on the hyperbolic Ricci flow method and tensor-based morphometry (TBM) statistics. Unlike prior ventricular surface parameterization methods, hyperbolic conformal parameterization is angle-preserving and does not have any singularities. Our system generates a one-to-one diffeomorphic mapping between ventricular surfaces with consistent boundary matching conditions. The TBM statistics encode a great deal of surface deformation information that could be inaccessible or overlooked by other methods. We applied our system to the baseline MRI scans of a set of MCI subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI: 71 MCI converters vs. 62 MCI stable). Although the combined ventricular area and volume features did not differ between the two groups, our fine-grained surface analysis revealed significant differences in the ventricular regions close to the temporal lobe and posterior cingulate, structures that are affected early in AD. Significant correlations were also detected between ventricular morphometry, neuropsychological measures, and a previously described imaging index based on fluorodeoxyglucose positron emission tomography (FDG-PET) scans. This novel ventricular morphometry method may offer a new and more sensitive approach to study preclinical and early symptomatic stage AD.

show abstract

Hippocampal structure and human cognition: Key role of spatial processing and evidence supporting the efficiency hypothesis in females

Cited by 40 publications

References 52 publications

Sex differences in neocortical structure and cognitive performance: A surface-based morphometry study

Sex differences in neocortical structure and cognitive performance: A surface-based morphometry study

Sex differences in visual-spatial working memory: A meta-analysis

Studying ventricular abnormalities in mild cognitive impairment with hyperbolic Ricci flow and tensor-based morphometry

Contact Info

Product

Resources

About