Hippocampal stimulation rebound effects in hamsters

The Hippocampus as a Cognitive Map

“…* In agreement with lesion results, however, is the finding that electrical stimulation facilitates two-way active avoidance (Stein 1965) and disrupts performance on a VI-45 operant schedule (Oliver et al 1973).…”

“…Another effect which might be explained in this way concerns the self-stimulation sometimes (Ursin et al 1966, Milgram 1969a, Brown and Winocur 1973, Oliver et al 1973 but not always (Stein 1965, Margules and Stein 1968, Milgram 1969a, Livesey and Wearne 1973 seen with hippocampal placements. A study by Jackson and Gardner (1974) demonstrated that hippocampal stimulation could effect hypothalamic self-stimulation, suggesting that self-stimulation in the hippocampus works through the hypothalamus.…”

“…Hippocampal stimulation-elicited eating and drinking differ from that seen with hypothalamic stimulation in two ways. First, they typically occur some time after stimulation, either as a rebound effect upon cessation of electrically induced after discharges (Milgram 1969a;Oliver et al 1973, Milgram et al 1975, or spreading depression elicited by KCl , Siegfried et al 1975, or after a seizure discharge has subsided (Mountford 1969). Second, the eating elicited by stimulation can be conditioned either to a signal (CS) or to the experimental situation itself (Siegfried et al 1975, Milgram et al 1975.…”

Attack, eating, drinking, and gnawing elicited by electrical stimulation of rat mesencephalon and pons.

“…A relatively large fraction of the 736 sites sampled in this study produced increases in grooming, eating, drinking, and gnawing that appeared after termination of stimulation. Milgram (1969) and Oliver, Firestone, and Goodman (1973) have reported similar increases in grooming, eating, and exploratory activity, but not drinking, after dorsolateral hippocampal stimulation. Although Milgram (1969) observed no behavioral responses in the two animals having ventral hippocampal electrodes, the present study obtained grooming, eating, and drinking from the medial ventral hippocampus.…”

Effect of food and water deprivation on hippocampal self-stimulation and poststimulation feeding

“…Stimulation of this region both supports self-stimulation and causes a facilitation of feeding which occurs following the offset of the stimulation (Milgram, 1969a;Oliver, Firestone, & Goodman, 1973). Unlike hypothalamic stimulation, the elicited behavioral consequences of hippocampal stimulation seem specific to feeding: drinking and other behaviors are not facilitated by hippocampal stimulation, even when special training procedures are employed (Milgram, 1969b).…”