2021
DOI: 10.3389/fphar.2021.673221
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Hippocampal PPARα Plays a Role in the Pharmacological Mechanism of Vortioxetine, a Multimodal-Acting Antidepressant

Abstract: As a well-known multimodal-acting antidepressant, vortioxetine is thought to aim at several serotonin (5-HT) receptors and the 5-HT transporter. However, recently more and more proteins besides 5-HT are being reported to participate in the antidepressant mechanism of vortioxetine. As a widely known nuclear hormone receptor, peroxisome proliferator activated receptor α (PPARα) possesses transcriptional activity and is very important in the brain. Several reports have suggested that hippocampal PPARα is implicat… Show more

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Cited by 6 publications
(5 citation statements)
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References 58 publications
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“…For each experiment, the mice were subjected to stratified randomization according to body weight, and all groups of mice were subjected to behavioral tests carried out during the light phase. The sample sizes were determined according to G. power analysis and our previous studies ( Jiang et al, 2019 ; Wang et al, 2020a , 2020b , 2021 ; Guan et al, 2021 ).…”
Section: Methodsmentioning
confidence: 99%
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“…For each experiment, the mice were subjected to stratified randomization according to body weight, and all groups of mice were subjected to behavioral tests carried out during the light phase. The sample sizes were determined according to G. power analysis and our previous studies ( Jiang et al, 2019 ; Wang et al, 2020a , 2020b , 2021 ; Guan et al, 2021 ).…”
Section: Methodsmentioning
confidence: 99%
“…The procedures for CUMS were performed according to our previous studies ( Xu et al, 2018 ; Jiang et al, 2019 ; Wang et al, 2020b , 2021 ). Except for the vehicle-treated control group, the mice were individually subjected to various stressors for a period of 8 weeks.…”
Section: Methodsmentioning
confidence: 99%
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“…Along the aforementioned, other mechanisms could be at play; vortioxetine showed antioxidative and anti-inflammatory activity on human monocytes and macrophages [ 27 ], and this matches the neuroinflammation hypothesis of depression. There is a recent hypothesis describing that vortioxetine induces antidepressant effects in mice models of depression by significantly promoting the hippocampal peroxisome proliferator activated receptor a (PPARα) expression, that is known to be involved in antidepressant response [ 28 ].…”
Section: Methodsmentioning
confidence: 99%