Abstract:Background
Although thought as a multimodal-acting antidepressant targeting at the serotonin system, more and more other molecules are being reported to participate in the antidepressant mechanism of vortioxetine. A previous report has shown that vortioxetine administration enhanced the expression of rapamycin complex 1 (mTORC1) in neurons. It has been well demonstrated that mTORC1 participates in not only the pathogenesis of depression but also the pharmacological mechanisms of many antidepr… Show more
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