Hippocampal neuroplasticity, major depression and, not to forget: ECT

Sartorius, Alexander; Karl, Sebastian; Zilles-Wegner, David

doi:10.1038/s41380-022-01746-w

Cited by 5 publications

(1 citation statement)

References 33 publications

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“…In addition to BDNF, vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF2), and nerve growth factor (NGF) have a significant role in MDD and favorable reaction to treatment [ 21 ]. The hippocampus is known to be susceptible to stress and may be particularly influenced by processes involved in immune system response, which could contribute to structural changes and impact antidepressant response [ 22 , 23 ].…”

Section: Neuroplasticitymentioning

confidence: 99%

Neurobiological mechanisms and therapeutic impact of electroconvulsive therapy (ECT)

Cojocaru,

Vasile,

Trifu

2024

Rom J Morphol Embryol

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Electroconvulsive therapy (ECT) is an efficient therapeutic resource for psycho-pharmacotherapeutic resistant forms of depression. ECT is a form of electrical brain stimulation involving the induction of a controlled seizure, clinically similar to an epileptic seizure, that is initiated in the prefrontal region of the brain and spreads to the cortex and subcortex, including the diencephalic structures. This is achieved by creating a transcranial electric field and synchronously depolarizing neuronal membranes. The mechanisms of action of ECT are not yet fully understood, but several hypotheses have been proposed to explain how it affects the brain: neurotransmitter changes, neuroplasticity, network connectivity, endocrine system regulation and changes in regional cerebral blood flow and regional metabolism.

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Section: Neuroplasticitymentioning

confidence: 99%