Hippocampal miR-206-3p participates in the pathogenesis of depression via regulating the expression of BDNF

Guan, Wei; De-sheng, XU; Ji, Chun-Hui; Wang, Chengniu; Liu, Yue; Tang, Wen; Gu, Jinlou; Chen, Yanmei; Huang, Jie; Liu, Jianfeng; Jiang, Bo

doi:10.1016/j.phrs.2021.105932

Cited by 45 publications

(24 citation statements)

References 46 publications

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“…Additionally, the mechanisms of BDNF regulation in the hippocampus are a hot research topic nowadays. Many singlestranded small non-coding ribonucleic acid (RNA) molecules, including miR-10b-5P (Wang et al, 2020), miR-202-3P (Xin et al, 2020), and miR-206-3P (Guan et al, 2021b) have been recently studied, as studies focused on the effects of other TCM on non-coding RNA molecules (Zhan et al, 2021). Research on the effects of quercetin on small non-coding RNA molecules has broad prospects.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

et al. 2022

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Depression is a global health problem with growing prevalence rates and serious impacts on the daily life of patients. However, the side effects of currently used antidepressants greatly reduce the compliance of patients. Quercetin is a flavonol present in fruits, vegetables, and Traditional Chinese medicine (TCM) that has been proved to have various pharmacological effects such as anti-depressant, anti-cancer, antibacterial, antioxidant, anti-inflammatory, and neuroprotective. This review summarizes the evidence for the pharmacological application of quercetin to treat depression. We clarified the mechanisms of quercetin regulating the levels of neurotransmitters, promoting the regeneration of hippocampal neurons, improving hypothalamic-pituitary-adrenal (HPA) axis dysfunction, and reducing inflammatory states and anti-oxidative stress. We also summarized the antidepressant effects of some quercetin glycoside derivatives to provide a reference for further research and clinical application.

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Section: Discussionmentioning

confidence: 99%

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

et al. 2022

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“…Vital River Laboratory Animal Technology Co., Ltd. (Beijing, China) provided the retired CD1 breeders (12 months old, 30-35g) that serves as aggressors in the chronic social defeat stress (CSDS) paradigm. Before use, all C57BL/6J mice were subjected to strati ed randomization according to body weight and maintained under standard conditions that have been fully described in our previous studies (Guan et al, 2021;Jiang et al, 2019;Liu et al, 2021;Song et al, 2018;Xu et al, 2018) for 1 week with water and food available ad libitum. All behavioural tests were carried out between 8: 00 am and 5: 00 pm, and afterwards, C57BL/6J subjects were randomly selected and sacri ced (anaesthetized by carbon dioxide rst and then killed by cervical dislocation) at 9: 00 am for all in vitro studies.…”

Section: Animalsmentioning

confidence: 99%

Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic–pituitary–adrenal axis

Wang

Liu

et al. 2022

Mol Psychiatry

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Elucidating the molecular mechanism underlying the hyperactivity of the hypothalamic-pituitaryadrenal axis during chronic stress is critical for understanding depression and treating depression. The secretion of corticotropin-releasing hormone (CRH) from neurons in the paraventricular nucleus (PVN) of the hypothalamus is controlled by salt-inducible kinases (SIKs) and CREB-regulated transcription coactivators (CRTCs). We hypothesized that the SIK-CRTC system in the PVN might contribute to the pathogenesis of depression. Thus, the present study employed chronic social defeat stress (CSDS) and chronic unpredictable mild stress (CUMS) models of depression, various behavioral tests, virus-mediated gene transfer, enzyme linked immunosorbent assay, western blotting, co-immunoprecipitation, quantitative real-time reverse transcription polymerase chain reaction, and immuno uorescence to investigate this connection. Our results revealed that both CSDS and CUMS induced signi cant changes in SIK1-CRTC1 signaling in PVN neurons. Both genetic knockdown of SIK1 and genetic overexpression of CRTC1 in the PVN simulated chronic stress, producing a depression-like phenotype in naïve mice, and the CRTC1-CREB-CRH pathway mediates the pro-depressant actions induced by SIK1 knockdown in the PVN.In contrast, both genetic overexpression of SIK1 and genetic knockdown of CRTC1 in the PVN protected against CSDS and CUMS, leading to antidepressant-like effects in mice. Moreover, stereotactic infusion of TAT-SIK1 into the PVN also produced bene cial effects against chronic stress. Furthermore, the SIK1-CRTC1 system in the PVN played a role in the antidepressant actions of uoxetine, paroxetine, venlafaxine, and duloxetine. Collectively, SIK1 and CRTC1 in PVN neurons are closely involved in depression neurobiology, and they could be viable targets for novel antidepressants.

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“…Other evidence showed that micro-RNA (miRNA) levels in brain could be altered by sleep deprivation [21]. And the bio-informatics analysis in the study revealed that both BDNF and miRNA-206 were differentially expressed genes in sleep deprivation [22]. Therefore, it was necessary to study the molecular mechanisms underlying miRNA-206 and BDNF-correlated sleep deprivation in mice.…”

Section: Discussionmentioning

confidence: 97%

Curcumin inhibits expression of brain derived neurotrophic factor (BDNF) in hippocampus of mice with sleep deprivation

Ruan¹,

He²,

Cao³

et al. 2023

Trop. J. Pharm Res

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Purpose: To determine the inhibitory effect of curcumin on the expression of brain-derived neurotrophic factor (BDNF) in hippocampus of mice with sleep deprivation. Methods: Expressions of BDNF and miRNA-206 were evaluated using quantitative real time-polymerase chain reaction (qRT-PCR) in a sleep-deprived mouse model. Interaction of BDNF and miRNA-206 was assessed by dual luciferase and qPCR) assays. The effect of curcumin on BDNF and miRNA-206 was also determined by qRT-PCR. Results: Expressions of BDNF and miRNA-206 were significantly suppressed in hippocampus of mice in sleep deprivation group compared with control mice (p < 0.05). Treatment with miRNA-206 significantly suppressed the luciferase activity of wild type (WT) BDNF reporter gene vector (p < 0.05) rather than the mutated (mut) vectors. Inhibition of miRNA-206 upregulated RNA and protein levels of BDNF (p < 0.05), while curcumin treatment inhibited BDNF expression (p < 0.01) and upregulated miRNA-206 level (p < 0.01). Conclusion: Curcumin inhibits BDNF expression by upregulating miRNA-206 level in hippocampus tissues of mice in the sleep deprivation model. The relationship between BDNF and miRNA-206 might provide a new direction for the development of new therapeutics for sleep deprivation.

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Hippocampal miR-206-3p participates in the pathogenesis of depression via regulating the expression of BDNF

Cited by 45 publications

References 46 publications

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

Antidepressant Potential of Quercetin and its Glycoside Derivatives: A Comprehensive Review and Update

Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic–pituitary–adrenal axis

Curcumin inhibits expression of brain derived neurotrophic factor (BDNF) in hippocampus of mice with sleep deprivation

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