Hippocampal malformation as a cause of familial febrile convulsions and subsequent hippocampal sclerosis

Fernández, Guillén; Effenberger, O; Vinz, Beate; Steinlein, Ortrud K.; Elger, Christian E.; Döhring, W.; Heinze, Hans Jochen

doi:10.1212/wnl.50.4.909

Cited by 223 publications

(157 citation statements)

References 42 publications

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“…However, there is no doubt that children with long-lasting lateralized febrile seizures are at risk for developing temporal lobe epilepsy (97), and magnetic resonance (MR) imaging has produced evidence of hippocampal injury after prolonged focal febrile seizures (100). However, another MR study found evidence of a subtle, preexisting hippocampal malformation as a cause of familial febrile seizures and subsequent hippocampal sclerosis (101). There is evidence demonstrating that mesial temporal sclerosis is both a result and a cause of seizures (102).…”

Section: Febrile Seizures and Type Of Later Epilepsymentioning

confidence: 99%

Febrile Seizures: Treatment and Prognosis

Knudsen

2000

Epilepsia

133

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Summary: Recent epidemiologic data indicate that the vast majority of children with febrile seizures have a normal long‐term outcome. A precise knowledge of the short‐ and long‐term outcome with or without treatment, and short‐ and long‐term side effects is an important prerequisite for assessing the various treatment strategies. We focus on the impact of short‐term or prophylactic treatment on the short‐ and long‐term outcome of various types of febrile seizures. There is universal agreement that daily prophylaxis with antiepileptic agents should never be used routinely in simple febrile seizures, but only in highly selected cases, if at all. Intermittent diazepam (DZP) prophylaxis at times of fever may or may not reduce the recurrence rate, but it does not appear to improve the long‐term outcome as compared with short‐term seizure control. The treatment may be used to reduce the recurrence rate for a small arbitrarily defined group with multiple simple febrile seizures, complex febrile seizures, especially focal, prolonged or both, febrile status, and when parental anxiety is severe. However, there is no evidence that treatment of simple febrile seizures can prevent the rare cases of later epilepsy, and many children with complex febrile seizures have a benign long‐term outcome, even without treatment. Many prefer a “wait and see” policy. An attractive alternative is to treat new febrile seizures with rectal DZP in solution at seizure onset, given by the parents at home to prevent febrile status. Newer, less well documented short‐term strategies include nasal, oral, or rectal administration of other benzodiazepines. Short‐term seizure control of febrile status and careful parental counseling are the two most important targets of treatment.

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Section: Febrile Seizures and Type Of Later Epilepsymentioning

confidence: 99%

Febrile Seizures: Treatment and Prognosis

Knudsen

2000

Epilepsia

133

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“…The association between temporal lobe development abnormalities -including focal cortical dysplasia (FCD) -and MTS is also recognized [55][56][57] . Therefore, although MTS is more commonly seen as an acquired pathology, presence of hippocampal malformation as a substrate for further development of MTS and TLE is frequently questioned 55,56,58 .…”

Section: Temporal Lobe Epilepsy: Surgical Pathologymentioning

confidence: 99%

“…Therefore, although MTS is more commonly seen as an acquired pathology, presence of hippocampal malformation as a substrate for further development of MTS and TLE is frequently questioned 55,56,58 .…”

Section: Temporal Lobe Epilepsy: Surgical Pathologymentioning

confidence: 99%

Surgical and postmortem pathology studies: contribution for the investigation of temporal lobe epilepsy

Caboclo

Neves

Jardim

et al. 2012

Arq. Neuro-Psiquiatr.

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Pathology studies in epilepsy patients bring useful information for comprehending the physiopathology of various forms of epilepsy, as well as aspects related to response to treatment and long-term prognosis. These studies are usually restricted to surgical specimens obtained from patients with refractory focal epilepsies. Therefore, most of them pertain to temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) and malformations of cortical development (MCD), thus providing information of a selected group of patients and restricted regions of the brain. Postmortem whole brain studies are rarely performed in epilepsy patients, however they may provide extensive information on brain pathology, allowing the analysis of areas beyond the putative epileptogenic zone. In this article, we reviewed pathology studies performed in epilepsy patients with emphasis on neuropathological findings in TLE with MTS and MCD. Furthermore, we reviewed data from postmortem studies and discussed the importance of performing these studies in epilepsy populations.

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“…Assim, por exemplo, mais recentemente tem sido considerada a possibilidade de essas alterações estruturais ocorrerem em familiares sem determinar manifestações clínicas de crises epilépticas 67 .…”

Section: Crise Febrilunclassified

“…Fernández et al 67 , em estudo realizado em duas famílias de sujeitos com epilepsia do lobo temporal e antecedente de crise febril, concluíram que a má-formação hipocampal é uma condição herdada que facilita a ocorrência das crises febris e não consequência destas. Além disso, a má-formação pode ser o ponto de partida para o desenvolvimento de esclerose hipocampal nos sujeitos com epilepsia do lobo temporal e antecedentes de crises febris.…”

Section: Crise Febrilunclassified

Estudo da prevalência de epilepsia em crianças e adolescentes da comunidade de Paraisópolis

Sampaio¹

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Patrícia Conde e Leandro Loureiro Buzatto, pelo carinho, disponibilidade e paciência na realização das entrevistas e organização dos dados. Aos funcionários do Setor de Neurofisiologia Clínica do Hospital IsraelitaAlbert Einstein, pelo apoio, amizade e disponibilidade de ajudar sempre que necessário.Ao Hospital Israelita Albert Einstein, por incentivar a dedicação à pesquisa, fornecendo meios para que ela possa ser realizada.A todas as crianças, meus profundos agradecimentos, não só por permitirem a realização deste trabalho, mas por trazerem sentido a ele. E a todos que, de uma maneira ou de outra, colaboraram para a realização desta tese. NORMALIZAÇÃO ADOTADAEsta tese está de acordo com as seguintes normas, em vigor no momento desta publicação: Referências: adaptado de International Committee of Medical JournalsEditors (Vancouver).

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Hippocampal malformation as a cause of familial febrile convulsions and subsequent hippocampal sclerosis

Abstract: These findings suggest a subtle, pre-existing hippocampal malformation that may facilitate febrile convulsions and contribute to the development of subsequent HS.

Cited by 223 publications

References 42 publications

Febrile Seizures: Treatment and Prognosis

Febrile Seizures: Treatment and Prognosis

Surgical and postmortem pathology studies: contribution for the investigation of temporal lobe epilepsy

Estudo da prevalência de epilepsia em crianças e adolescentes da comunidade de Paraisópolis

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