Hippocampal gene expression in a rat model of depression after electroacupuncture at the Baihui and Yintang acupoints

Duan, Dongmei; Yang, Xiuyan; Tu, Ya; Li-ping, Chen

doi:10.4103/1673-5374.125333

Cited by 33 publications

(26 citation statements)

References 42 publications

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“…The hippocampus is an important component of the limbic system and regulator of the hypothalamic-pituitary-adrenal (HPA) axis responses that its manipulation by steroid hormones had effect on anxiety and depression [15]. Furthermore, the positive effect of EA on anxiety behaviors via alterations of some molecular pathways in hippocampus in other rat models related to depression, stress, or pain has been shown [16–18]. …”

Section: Introductionmentioning

confidence: 99%

The Role of Hippocampal Estradiol Receptor-αin a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture

Wang

Huang

Yuan

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Hormone replacement therapy is the principal treatment for perimenopausal affective disorders which can cause severe side effects. The present study compared the effects of electroacupuncture (EA) and estradiol treatment on perimenopausal affective disorders at the behavioral and cellular levels. In this randomized experimental in vivo study, adult female rats were divided into intact, ovariectomy, chronic unpredictable stress (CUS), and ovariectomy and CUS combination groups. After week 6, all groups were subdivided to three subgroups of control, EA, and estradiol treatment. The behavioral parameters in the open field and the elevated plus maze tests were assessed before and after treatments. Alterations of serum steroid hormones and changes of estradiol receptor-α (ER-α) immunofluorescence neurons in the hippocampus sections were evaluated. EA treatment caused more antianxiety effects than estradiol treatment in CUS group (P < 0.05). Notably, estradiol and EA treatments had better significant behavioral effects when the models were not estrogen-deficient. Importantly, within each group, compared to the control group, the numbers of ER-α-positive neurons were significantly larger in EA subgroups. Therefore, EA had antianxiety effects on perimenopausal affective disorders caused by CUS but not by estrogen deficiency and upregulation of hippocampus ER-α neurons may contribute to its mechanism of action.

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Section: Introductionmentioning

confidence: 99%

The Role of Hippocampal Estradiol Receptor-αin a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture

Wang

Huang

Yuan

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…[7] Combined with the effect of electrical stimulation, it can produce different treatment effect at different acupoints by adjusting the waveform, time, frequency, and intensity parameters. [8][9][10] Studies showed that treatment with EA could improve cognitive function in patients with Alzheimer disease. [11] Our previous study suggested that preconditioning of EA could reduce the incidence the postoperative cognitive dysfunction in aged rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of preconditioning of electro-acupuncture on postoperative cognitive dysfunction in elderly: A prospective, randomized, controlled trial

Zhang

Y-Y

et al. 2017

Deutsche Zeitschrift für Akupunktur

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Electro-acupuncture is a burgeoning treatment using the needle inserting into the body acupoints and the low-frequency pulse current being electrified by an electric acupuncture machine. This study was designed to evaluate the effects of preconditioning of electro-acupuncture on postoperative cognitive dysfunction in elderly.Ninety patients scheduled spine surgery were randomly assigned into 2 groups using a random number table: control group (group C) and electro-acupuncture group (group EA). In group EA, electro-acupuncture was applied on Baihui, Dazhui, and Zusanli acupoints 30 minutes before anesthesia. At 0 minute before treatment of electro-acupuncture, 1 hour after skin incision and surgery completed (T 1-3 ), blood samples were taken for detection of interleukin (IL)-6, IL-10, and S100b by enzyme-linked immunosorbent assay. The total dose of remifentanil and propofol during surgery were recorded. Mini-Mental State Examination was applied to evaluate the cognitive function of patients at 1 day before surgery and 7th and 30th day after surgery.The results showed that compared with group C, score of MMSE increased after surgery, the serum concentration of IL-6, IL-10, and S100b decreased at 1 hour after skin incision, and surgery completed in group EA. Moreover, the total dose of remifentanil and propofol reduced during surgery in group EA.The present study suggests that preconditioning of electro-acupuncture could improve the postoperative cognitive function, and the reduction of inflammatory reaction and brain injury may be involved in the mechanism.Abbreviations: ASA = American Standards Association, BIS =bispectral index, BMI = body mass index, EA = electroacupuncture, MMSE = Mini-Mental State Examination, POCD = postoperative cognitive dysfunction.

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“…The EA treatment was similar as previously described [19]. EA treatment at Baihui (GV 20, the center of parietal bone) and Yintang (EX-HN3, the middle point of the line between the brow bones) points was conducted for depressed model rats for 28 days (from day 33 to day 59).…”

Section: Methodsmentioning

confidence: 99%

Electroacupuncture Restores 5-HT System Deficit in Chronic Mild Stress-Induced Depressed Rats

Duan

Yang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Objective. The current study is designed to investigate the antidepressant efficacy of electroacupuncture (EA) treatment by evaluating its effect on the synthesis, metabolism, reuptake, and receptors of 5-hydroxytryptamine (5-HT), so as to clarify the molecular mechanisms of EA for antidepression. Materials and Methods. Solitary combined with the chronic unpredictable mild stress (CUMS) was used to establish the rat model with depression. The depressed rats were supplied with EA treatment for 4 weeks, and the behavior change and the following indices including 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), monoamine oxidase A (MAO-A), tryptophan hydroxylase (TPH), 5-HT transporter (SERT), 5-HT1A, and 5-HT2A in hippocampus and prefrontal cortex were examined. Results. EA treatment significantly improved the behavior of rats and increased 5-HT level in hippocampus of depressed rats. Similarly, EA treatment could significantly increase protein and mRNA expression of TPH and 5-HT1A during 5-HT synthesis process in hippocampus of depressed rats. However, EA treatment had no effect on the activity of MAO-A and the expression of SERT protein and mRNA. Conclusion. Antidepressant efficacy of EA treatment can be accomplished through enhancing 5-HT synthesis, upregulating 5-HT1A level, and improving 5-HT content in brain and synaptic gaps.

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Hippocampal gene expression in a rat model of depression after electroacupuncture at the Baihui and Yintang acupoints

Cited by 33 publications

References 42 publications

The Role of Hippocampal Estradiol Receptor-αin a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture

The Role of Hippocampal Estradiol Receptor-αin a Perimenopausal Affective Disorders-Like Rat Model and Attenuating of Anxiety by Electroacupuncture

Effects of preconditioning of electro-acupuncture on postoperative cognitive dysfunction in elderly: A prospective, randomized, controlled trial

Electroacupuncture Restores 5-HT System Deficit in Chronic Mild Stress-Induced Depressed Rats

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