Electroacupuncture Restores 5‐HT System Deficit in Chronic Mild Stress‐Induced Depressed Rats

Duan, Dongmei; Tu, Ya; Yang, Xiuyan; Liu, Ping

doi:10.1155/2016/7950635

Cited by 16 publications

(29 citation statements)

References 32 publications

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“…In our results, 5 ‐ HIAA was decreased in stress ‐ susceptible mice compared with control mice, which has also been observed in the HIPPO of chronic mild stress ‐ induced depressed rats (Duan et al . ). The perturbed 5 ‐ HIAA is in contrast to the results of a previous study that reported no difference in the concentration of 5 ‐ HIAA in the HIPPO of methylprednisolone ‐ induced depressed mice (Huang et al .…”

Section: Discussionmentioning

confidence: 97%

Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice

Chen

et al. 2019

Journal of Neurochemistry

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The proportion of major depressive disorder (MDD) patients around the world has increased remarkably. Although many studies of MDD have been conducted based on classic hypotheses, like alteration of the hypothalamic–pituitary–adrenal axis or monoamine neurotransmitters, the mechanisms underlying MDD remain unclear. Aiming to further investigate the mechanisms of MDD, liquid chromatography–tandem mass spectrometry was employed to measure target metabolites in the hippocampus (HIPPO) of chronic social defeat stress model mice. Compared with control mice, stress‐susceptible mice showed a reduction of 5‐hydroxyindoleacetic acid and kynurenic acid in the tryptophan pathway, and an increased level of dopamine in the catecholamine pathway, while stress‐resilient mice displayed a reduction of 5‐hydroxytryptamine in the tryptophan pathway. The altered levels of key molecules related to the tryptophan or dopamine metabolic pathways were validated by real‐time quantitative polymerase chain reaction or western blotting. Comparative analysis with previous targeted metabolomics results in the prefrontal cortex (PFC) of chronic social defeat stress mice revealed that the altered metabolites manifested in specific brain areas, and only the dopamine metabolic pathway was perturbed in both the HIPPO and PFC after stress. Additionally, correlation analysis validated that levels of kynurenic acid in the HIPPO, along with glutamic acid, L‐3, 4‐dihydroxyphenylalanine, and vanillylmandelic acid in the PFC, were correlated with depression‐like behaviors. This study provides a unique perspective on the potential molecular mechanisms of stress susceptibility and stress resilience.

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Section: Discussionmentioning

confidence: 97%

Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice

Chen

et al. 2019

Journal of Neurochemistry

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“…The pathophysiology of depression is complex and involves several different signaling pathways. 5‐HT, as a neurotransmitter, is confirmed to be involved in depression . Several studies have established that the lack of gut microbiota encourages depression‐like behavior in rats, adjusting the composition of gut microbiota could effectively improve the behavior of CUMS rats through providing probiotics and prebiotics .…”

Section: Discussionmentioning

confidence: 99%

“…5-HT, as a neurotransmitter, is confirmed to be involved in depression. 26 Several studies have established that improve the behavior of CUMS rats through providing probiotics and prebiotics. 29 Jessica M. Yano has previously reported that Indigenous bacteria from the gut microbiota modulate metabolites which stimulate colon 5-HT biosynthesis.…”

Section: Discussionmentioning

confidence: 99%

Effects of regulating gut microbiota on the serotonin metabolism in the chronic unpredictable mild stress rat model

Wang

Huang

et al. 2019

Neurogastroenterology Motil

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Objective This study was to inspect the antidepressant‑like effect of prebiotics and probiotics, and to explore the effect of modulating gut microbiota on the serotonin (5‐HT) metabolism. Methods Fifty rats were separated into control and other four groups randomly. The four groups underwent the chronic unpredictable mild stress (CUMS) intervention with or without prebiotics and probiotics (Bifidobacterium longum, L. rhamnosus) treatment. After weighted, the animals underwent a series of behavioral tests comprising the sucrose preference test (SPT) and the forced swimming test (FST). Central and colonic serotonin levels and relative metabolism factors were measured and analyzed. Microbiota was examined by 16S rRNA gene pyrosequencing. Results CUMS intervention caused a decrease in body weight, an increase in FST, and a decrease in SPT. Prebiotics and probiotics all ameliorated the CUMS‐induced loss of weight and depressive‐like behaviors to a certain extent, especially L. rhamnosus. Compared with the group of CUMS intervention, the rats of probiotics and probiotics treatment had a tendency to reduce colonic 5‐HT and increase 5‐HT in frontal cortex and hippocampus. However, there was no significant difference in peripheral blood 5‐HT among these groups. Furthermore, CUMS caused noteworthy gut microbiota variations at the phylum and other levels in rats. Remarkably, there were considerable relations of perturbed gut microbiota with the changed metabolism of 5‐HT. Conclusion In conclusion, these findings implied that prebiotics and probiotics have antidepressive effects, and a considerable effect on the regulation of 5‐HT metabolism, especially L. rhamnosus.

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“… Up-regulated expression levels of PKA mRNA and TrkB mRNA and down-regulated expression levels of CaMKII mRNA in the hippocampus. Duan 2016# 20 Increased 5-HT in hippocampus. Increased 5-HIAA level.…”

Section: Resultsmentioning

confidence: 99%

“… Duan 2008 18 CUMS & Solitary Wistar rats Male 150–180 10/10 mention not mention SAME EA GV20,GV29,EX-HNl mention 20 min 21 21d Fluoxetine OFT:NC,NR; W:FW. Duan 2016 19 CUMS SD rats Male 150 ± 10 16/16 mention not mention NOT SAME EA GV20,GV29 mention 30 min 28 28d Fluoxetine OFT:NC,NR;W:FW; Duan 2016# 20 CUMS & Solitary Wistar rats Male 180–200 10/10 mention not mention NOT SAME EA GV20,GV29 mention 20 min 28 28d Fluoxetine OFT:NC,NR;W:FW; SI:RSI. Fan 2013 21 CUMS & Solitary SD rats Female/Male 170–220 10/10 Random number table not mention SAME MA EX-HNl,PC6,SP6 mention 30 min 21 21d Fluoxetine OFT:NC,NR; |W:FW; SI:CSI.…”

Section: Resultsmentioning

confidence: 99%

Acupuncture for behavioral changes of experimental depressive disorder: a systematic review and meta-analysis

Kou

Chen

et al. 2017

Sci Rep

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Acupuncture is considered to be a promising alternative therapy for depression. Nevertheless, up to now, it remains controversial on the effects exerted by acupuncture on behavioral changes in depression models. Consequently, it’s necessary to develop a systematic review and meta-analysis to assess the effect of acupuncture for model rats of depression. Ultimately, 90 studies involving 1861 models were identified. Behavioral indicators including the number of crossings (NC) and the number of rearings (NR) in open field test (OFT), the capacity of sucrose intake (CSI) and the rate of sucrose intake (RSI) in sucrose intake test (SIT), final weight (FW) and gain weight (GW) were employed as main outcomes in depression model rats. The pooled results showed that acupuncture had not less effect than western medicine on improving NC, NR, FW, GW, RSI (P > 0.05). However, the CSI improvement was poorer compared with west medicine (P < 0.05). In conclusion, acupuncture has not less effect on behavior changes than western medicine, including improving NC, NR, RSI, FW and GW in depression models.

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Electroacupuncture Restores 5‐HT System Deficit in Chronic Mild Stress‐Induced Depressed Rats

Cited by 16 publications

References 32 publications

Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice

Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice

Effects of regulating gut microbiota on the serotonin metabolism in the chronic unpredictable mild stress rat model

Acupuncture for behavioral changes of experimental depressive disorder: a systematic review and meta-analysis

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