2014
DOI: 10.1016/j.bbr.2014.01.012
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Hippocampal biomarkers of fear memory in an animal model of generalized anxiety disorder

Abstract: Generalized anxiety disorder (GAD) is highly prevalent and incapacitating. Here we used the Carioca High-Conditioned Freezing (CHF) rats, a previously validated animal model for GAD, to identify biomarkers and structural changes in the hippocampus that could be part of the underlying mechanisms of their high-anxiety profile. Spatial and fear memory was assessed in the Morris water maze and passive avoidance test. Serum corticosterone levels, immunofluorescence for glucocorticoid receptors (GR) in the dentate g… Show more

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Cited by 48 publications
(43 citation statements)
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“…Furthermore, Dias and colleagues also found a decreased number of immature neurons in the dentate gyrus of a rodent model with generalized anxiety [51]. Consistent with the previous studies [4451], we confirmed that the in vivo expression of reprogramming factors facilitated hippocampal neurogenesis and hippocampus-related behavioral outcomes such as increased long-term memory and decreased anxiety-related behavior. Additionally, when neurobehavioral tests were performed in sham-operated control group and treatment group, there was no significant difference between two groups.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Furthermore, Dias and colleagues also found a decreased number of immature neurons in the dentate gyrus of a rodent model with generalized anxiety [51]. Consistent with the previous studies [4451], we confirmed that the in vivo expression of reprogramming factors facilitated hippocampal neurogenesis and hippocampus-related behavioral outcomes such as increased long-term memory and decreased anxiety-related behavior. Additionally, when neurobehavioral tests were performed in sham-operated control group and treatment group, there was no significant difference between two groups.…”
Section: Discussionsupporting
confidence: 92%
“…In that study, the authors demonstrated that deficits in hippocampal neurogenesis via specific ablation of newborn neurons in the adult dentate gyrus resulted in anxious behavior [50]. Furthermore, Dias and colleagues also found a decreased number of immature neurons in the dentate gyrus of a rodent model with generalized anxiety [51]. Consistent with the previous studies [4451], we confirmed that the in vivo expression of reprogramming factors facilitated hippocampal neurogenesis and hippocampus-related behavioral outcomes such as increased long-term memory and decreased anxiety-related behavior.…”
Section: Discussionmentioning
confidence: 99%
“…Although we did not evaluate GR expression in the present study, Dias et al studying CHF animals in fact did it [12], so we cannot discard an eventual relationship between hippocampal GR alterations and the high levels of serum corticosterone found here.…”
Section: Discussioncontrasting
confidence: 62%
“…Although hippocampal abnormalities have been proposed in patients with GAD (Dias et al, 2014), the association between functional and morphometric changes in this area has not been clearly identified. A number of studies (Eichenbaum, 2000;Engin et al, 2007;Femenía et al, 2012;Small et al, 2011) have reported that the Hip plays an essential role in memory storage and retrieval in various cognitive functions, as well as in the integration of emotion and cognition.…”
Section: Discussionmentioning
confidence: 97%