Explicit verbal memory impairments associated with brain functional deficits and morphological alterations in patients with generalized anxiety disorder

Moon, Chung-Man; Yang, Jong-Chul; Jeong, Gwang‐Woo

doi:10.1016/j.jad.2015.07.038

Cited by 39 publications

(57 citation statements)

References 50 publications

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“…Although GAD is a highly prevalent and incapacitating disorder, previous studies (Price et al, 2011;Ball et al, 2013;Moon et al, 2015a;Moon et al, 2015b) focusing on the cognitive dysfunctions in GAD have been performed and it is still unclear whether cerebral metabolic change is associated with the brain activation patterns during the WM tasks with emotional distraction. Therefore, it is assumed that a combined use of the fMRI and 1 H-MRS provides more valuable information on the neural mechanisms associated with GAD dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…Anxiety levels were then assessed using various psychiatric rating scales (Moon et al, 2015a): Hamilton Anxiety Rating Scale (HARS; 14 items with a 5-level scale, cutoff score >14; Hamilton, 1959), Hamilton Rating Scale for Depression 17 (HAMD-17; 8 items with a 5-level scale and 9 items with a 3-level scale, cutoff score >7; Hamilton, 1960), Generalized Anxiety Disorder Scale 7 (GAD-7; 7 items with a 4-level scale, cutoff score >4; Spitzer et al, 2006), State-Trait Anxiety Inventory I (STAI-I; 20 items with a 4-level scale; cutoff score >51; Spielberger et al, 1970), State-Trait Anxiety Inventory II (STAI-II; 20 items with a 4-level scale, cutoff score >53; Spielberger et al, 1970), and Anxiety Sensitivity Index-Revised (ASI-R; 36 items with a 5-level scale, cutoff score >28; Taylor et al, 1998) (Table 1).…”

Section: Assessment Of Anxiety Levelsmentioning

confidence: 99%

“…In the course of the SPM8 analysis (Moon et al, 2015a), the images were realigned to correct the head movement and were spatially normalized to the Montreal Neurological Institute (MNI) EPI template images. Normalized images were smoothed with 8 mm FWHM Gaussian filter to increase signal-to-noise.…”

Section: Data Processing and Statistical Analyses 251 Functional Bmentioning

confidence: 99%

“…Anatomical labeling for the activation areas was implemented using Functional and Anatomical Labeling of Brain Activation (FALBA) software (Kim et al, 2010), which is capable of identifying the brain areas and quantifying the brain activities as well. Simple correlations between BOLD signal changes in activation conditions and brain metabolic changes in both groups were analyzed by Pearson's correlation test with a 95% confidence interval (Moon et al, 2015a). The differences of anxiety levels and facial recognition accuracy (%) in both groups were analyzed by Mann-Whitney U test as well as mean and standard deviation (SD) were calculated using SPSS 19.0 (Chicago, IL, USA).…”

Section: Data Processing and Statistical Analyses 251 Functional Bmentioning

confidence: 99%

“…Recent studies (Moon et al, 2014;Moon et al, 2015a) reported that severe anxiety symptoms lead to emotional disorders including unsuppressed anger and low frustration tolerance, and/or cognitive disorders including low attention and memory deficits. The diagnosis of GAD relies on traditional evaluation methods based on clinical questionnaires (Rickels et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Working memory dysfunction associated with brain functional deficits and cellular metabolic changes in patients with generalized anxiety disorder

Moon

Sundaram

Choi

et al. 2016

Psychiatry Research: Neuroimaging

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Section: Discussionmentioning

confidence: 99%

Section: Assessment Of Anxiety Levelsmentioning

confidence: 99%

Section: Data Processing and Statistical Analyses 251 Functional Bmentioning

confidence: 99%

Section: Data Processing and Statistical Analyses 251 Functional Bmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Working memory dysfunction associated with brain functional deficits and cellular metabolic changes in patients with generalized anxiety disorder

Moon

Sundaram

Choi

et al. 2016

Psychiatry Research: Neuroimaging

Self Cite

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Reduced cortical volume of the default mode network in adolescents with generalized anxiety disorder

Bashford‐Largo

Zhang

Mathur

et al. 2022

Depression and Anxiety

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Background: Widespread structural alterations have been shown to be implicated in individuals with generalized anxiety disorder (GAD). However, there have been inconsistent findings in cortical volume (CV) differences. Most structural neuroimaging studies looking at GAD used region-based approach with relatively small sample sizes, let alone be specific to adolescents with GAD. We believe this is the first study to look at CV measures using a network-based approach in a larger sample of adolescents with GAD. The goal of the current study was to focus on three different brain networks (i.e., Limbic, Frontoparietal, and Default Mode Network [DMN]) in adolescents with GAD. Method: The study involved 81 adolescents with GAD and 112 typically developing (TD) comparison individuals matched on age (15.98 and 15.63 respective means), sex (42F/39M and 45F/67M), and IQ (101.90 and 103.94 respective means). Participants underwent structural MRI. Freesurfer was used to estimate CV (both network-specific and region-specific within networks) and region-specific subcortical volume measures. Multivariate analysis of covariance (MANCOVA; with sex, age, IQ, and intracranial volume [ICV] as potential covariates) was used to estimate group differences.Results: We found significantly lower CV for the DMN in adolescents with GAD, compared with TD individuals. Adolescents with GAD also showed significantly lower hemispheric mean CV of the default-mode regions (particularly the prefrontal and temporal regions) and the hippocampus, compared with TD individuals. Conclusion:The current findings suggest structural alterations in adolescents with GAD. These structural alterations will need to be addressed when implementing and developing treatments for patients with GAD.

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Dynamic changes of amplitude of low‐frequency fluctuations in patients with generalized anxiety disorder

Cui

Sheng

Chen

et al. 2019

Human Brain Mapping

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101

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Previous neuroimaging studies have mainly focused on alterations of static and dynamic functional connectivity in patients with generalized anxiety disorder (GAD). However, the characteristics of local brain activity over time in GAD are poorly understood. This study aimed to investigate the abnormal time‐varying local brain activity of GAD by using the amplitude of low‐frequency fluctuation (ALFF) method combined with sliding‐window approach. Group comparison results showed that compared with healthy controls (HCs), patients with GAD exhibited increased dynamic ALFF (dALFF) variability in widespread regions, including the bilateral dorsomedial prefrontal cortex, hippocampus, thalamus, striatum; and left orbital frontal gyrus, inferior parietal lobule, temporal pole, inferior temporal gyrus, and fusiform gyrus. The abnormal dALFF could be used to distinguish between patients with GAD and HCs. Increased dALFF variability values in the striatum were positively correlated with GAD symptom severity. These findings suggest that GAD patients are associated with abnormal temporal variability of local brain activity in regions implicated in executive, emotional, and social function. This study provides insight into the brain dysfunction of GAD from the perspective of dynamic local brain activity, highlighting the important role of dALFF variability in understanding neurophysiological mechanisms and potentially informing the diagnosis of GAD.

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Explicit verbal memory impairments associated with brain functional deficits and morphological alterations in patients with generalized anxiety disorder

Cited by 39 publications

References 50 publications

Working memory dysfunction associated with brain functional deficits and cellular metabolic changes in patients with generalized anxiety disorder

Working memory dysfunction associated with brain functional deficits and cellular metabolic changes in patients with generalized anxiety disorder

Reduced cortical volume of the default mode network in adolescents with generalized anxiety disorder

Dynamic changes of amplitude of low‐frequency fluctuations in patients with generalized anxiety disorder

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