Hippocampal and orbital inferior frontal gray matter volume abnormalities and cognitive deficit in treatment-naive, first-episode patients with schizophrenia

Guo, Xiaofeng; Li, Jun; Wang, Juan; Fan, Xiaoduo; Hu, Maorong; Shen, Yidong; Chen, Huafu; Zhao, Jingping

doi:10.1016/j.schres.2013.12.015

Cited by 70 publications

(45 citation statements)

References 44 publications

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“…Broad, overlapping GMD reductions in the frontotemporal and parietal regions in both B1 and B2 are consistent with the poor cognitive function observed in these probands. Such associations between frontotemporal GM alterations and cognitive dysfunction have been previously reported in the psychosis samples (55–58). In addition, frontotemporal as well as subcortical (e.g., thalamus) and posterior (temporo-occipital) sensory regions have been implicated in sensorimotor processing captured with source localization paradigms in healthy and psychotic populations (59,60).…”

Section: Discussionsupporting

confidence: 80%

Brain Structure Biomarkers in the Psychosis Biotypes: Findings From the Bipolar-Schizophrenia Network for Intermediate Phenotypes

Ivleva

Clementz

Dutcher

et al. 2017

Biological Psychiatry

120

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Section: Discussionsupporting

confidence: 80%

Brain Structure Biomarkers in the Psychosis Biotypes: Findings From the Bipolar-Schizophrenia Network for Intermediate Phenotypes

Ivleva

Clementz

Dutcher

et al. 2017

Biological Psychiatry

120

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“…Structural abnormalities in the frontal lobe, particularly within the prefrontal cortex, have been a consistent observation in patients with schizophrenia (Benes et al, 1991; Goldman et al, 1997) and may underlie cognitive deficits (Guo et al, 2014; Nakamura et al, 2008). Our in situ hybridization results in the frontal cortex (Fig.…”

Section: Discussionmentioning

confidence: 99%

Postnatal neurodevelopmental expression and glutamate-dependent regulation of the ZNF804A rodent homologue

Chang

Kirtley

Chandon

et al. 2015

Schizophrenia Research

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The zinc finger protein ZNF804A rs1344706 variant is a replicated genome-wide significant risk variant for schizophrenia and bipolar disorder. While its association with altered brain structure and cognition in patients and healthy risk allele carriers is well documented, the characteristics and function of the gene in the brain remains poorly understood. Here, we used in situ hybridization to determine mRNA expression levels of the ZNF804A rodent homologue, Zfp804a, across multiple postnatal neurodevelopmental timepoints in the rat brain. We found changes in Zfp804a expression in the rat hippocampus, frontal cortex, and thalamus across postnatal neurodevelopment. Zfp804a mRNA peaked at postnatal day (P) 21 in hippocampal CA1 and DG regions, and was highest in the lower cortical layers of frontal cortex at P1, possibly highlighting a role in developmental migration. Using immunofluorescence, we found that ZFP804A co-localized with neurons and not astrocytes. In primary cultured cortical neurons, we found that Zfp804a expression was significantly increased when neurons were exposed to glutamate [20 μM], but this increase was blocked by the N-methyl-D-aspartate receptor (NMDAR) antagonist MK-801. Expression of Comt, Pde4b, and Drd2, genes previously shown to be regulated by ZNF804A overexpression, were also significantly changed in an NMDA-dependent manner. Our results describe, for the first time, the unique postnatal neurodevelopmental expression of Zfp804a in the rodent brain and demonstrate that glutamate potentially plays an important role in the regulation of this psychiatric susceptibility gene. These are critical steps towards understanding the biological function of ZNF804A in the mammalian brain.

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“…In human, MRI images revealed that patients with neurological and/or psychiatric diseases, including Alzheimer's disease, schizophrenia and depression, have a smaller volume of hippocampi than those of control subjects (Francis et al, 2013;Guo et al, 2014;Heckers and Konradi, 2010;Prestia et al, 2014;Reif et al, 2006;Rizos et al, 2014). One possibility for those findings is that neurogenesis may be decreased in those patients.…”

Section: Fabps and Neurogenesismentioning

confidence: 99%

Fatty acid binding proteins and the nervous system: Their impact on mental conditions

Matsumata

Inada

Osumi

2016

Neuroscience Research

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The brain is rich in lipid and fatty molecules. In this review article, we focus on fatty acid binding proteins (Fabps) that bind to fatty acids such as arachidonic acid and docosahexianoic acid and transfer these lipid ligands within the cytoplasm. Among Fabp family molecules, Fabp3, Fabp5, and Fabp7 are specifically localized in neural stem/progenitor cells, neurons and glia in a cell-type specific manner. Quantitative trait locus analysis has revealed that Fabp7 is related with performance of prepulse inhibition (PPI) that is used as an endophenotype of psychiatric diseases such as schizophrenia. Fabp5 and Fabp7 play important roles on neurogenesis and differentially regulate acoustic startle response and PPI. However, other behavior performances including spatial memory, anxiety-like behavior, and diurnal changes in general activity were not different in mice deficient for Fabp7 or Fabp5. Considering the importance of fatty acids in neurogenesis, we would like to emphasize that lipid nutrition and its dynamism via Fabps play significant roles in mental conditions. This might provide a good example of how nutritional environment can affect psychiatric conditions at the molecular level.

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Hippocampal and orbital inferior frontal gray matter volume abnormalities and cognitive deficit in treatment-naive, first-episode patients with schizophrenia

Cited by 70 publications

References 44 publications

Brain Structure Biomarkers in the Psychosis Biotypes: Findings From the Bipolar-Schizophrenia Network for Intermediate Phenotypes

Brain Structure Biomarkers in the Psychosis Biotypes: Findings From the Bipolar-Schizophrenia Network for Intermediate Phenotypes

Postnatal neurodevelopmental expression and glutamate-dependent regulation of the ZNF804A rodent homologue

Fatty acid binding proteins and the nervous system: Their impact on mental conditions

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