Fatty acid binding proteins and the nervous system: Their impact on mental conditions

Matsumata, Miho; Inada, Hitoshi; Osumi, Noriko

doi:10.1016/j.neures.2014.08.012

Cited by 47 publications

(44 citation statements)

References 72 publications

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“…Interestingly, P0 has also been shown to promote neurite outgrowth (Schneider-Schaulies et al, 1990;Filbin and Tennekoon, 1992). As for Fabp7, a role in regulating Schwann cell-axon interactions has been proposed (Miller et al, 2003) and it is certainly critical for neurogenesis in the CNS (recently reviewed in Matsumata et al, 2014), but its function in peripheral glia remains unclear.…”

Section: Peripheral Glia Markers and Their Functionsmentioning

confidence: 99%

Transcriptional control of neural crest specification into peripheral glia

Jacob

2015

Glia

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The neural crest is a transient migratory multipotent cell population that originates from the neural plate border and is formed at the end of gastrulation and during neurulation in vertebrate embryos. These cells give rise to many different cell types of the body such as chondrocytes, smooth muscle cells, endocrine cells, melanocytes, and cells of the peripheral nervous system including different subtypes of neurons and peripheral glia. Acquisition of lineage-specific markers occurs before or during migration and/or at final destination. What are the mechanisms that direct specification of neural crest cells into a specific lineage and how do neural crest cells decide on a specific migration route? Those are fascinating and complex questions that have existed for decades and are still in the research focus of developmental biologists. This review discusses transcriptional events and regulations occurring in neural crest cells and derived lineages, which control specification of peripheral glia, namely Schwann cell precursors that interact with peripheral axons and further differentiate into myelinating or nonmyelinating Schwann cells, satellite cells that remain tightly associated with neuronal cell bodies in sensory and autonomous ganglia, and olfactory ensheathing cells that wrap olfactory axons, both at the periphery in the olfactory mucosa and in the central nervous system in the olfactory bulb. Markers of the different peripheral glia lineages including intermediate multipotent cells such as boundary cap cells, as well as the functions of these specific markers, are also reviewed. Enteric ganglia, another type of peripheral glia, will not be discussed in this review.

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Section: Peripheral Glia Markers and Their Functionsmentioning

confidence: 99%

Transcriptional control of neural crest specification into peripheral glia

Jacob

2015

Glia

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“…; Matsumata et al. ) and the interaction of EGR‐1 and the PPAR pathway has been described in relation to cardiovascular risk (Fruchart ).…”

Section: Discussionmentioning

confidence: 99%

“…EGR4 is also upregulated by EGFR signaling (Mayer et al 2009), linked to myelination and remyelination (Aguirre et al 2007). Both fatty acids and EGR signaling have been associated with mental illnesses including schizophrenia (Yamada et al 2007;Matsumata et al 2014) and the interaction of EGR-1 and the PPAR pathway has been described in relation to cardiovascular risk (Fruchart 2009).…”

Section: Discussionmentioning

confidence: 99%

Possible relationship between common genetic variation and white matter development in a pilot study of preterm infants

et al. 2016

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BackgroundThe consequences of preterm birth are a major public health concern with high rates of ensuing multisystem morbidity, and uncertain biological mechanisms. Common genetic variation may mediate vulnerability to the insult of prematurity and provide opportunities to predict and modify risk.ObjectiveTo gain novel biological and therapeutic insights from the integrated analysis of magnetic resonance imaging and genetic data, informed by prior knowledge.MethodsWe apply our previously validated pathway‐based statistical method and a novel network‐based method to discover sources of common genetic variation associated with imaging features indicative of structural brain damage.ResultsLipid pathways were highly ranked by Pathways Sparse Reduced Rank Regression in a model examining the effect of prematurity, and PPAR (peroxisome proliferator‐activated receptor) signaling was the highest ranked pathway once degree of prematurity was accounted for. Within the PPAR pathway, five genes were found by Graph Guided Group Lasso to be highly associated with the phenotype: aquaporin 7 (AQP7), malic enzyme 1, NADP(+)‐dependent, cytosolic (ME1), perilipin 1 (PLIN1), solute carrier family 27 (fatty acid transporter), member 1 (SLC27A1), and acetyl‐CoA acyltransferase 1 (ACAA1). Expression of four of these (ACAA1, AQP7, ME1, and SLC27A1) is controlled by a common transcription factor, early growth response 4 (EGR‐4).ConclusionsThis suggests an important role for lipid pathways in influencing development of white matter in preterm infants, and in particular a significant role for interindividual genetic variation in PPAR signaling.

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“…Total RNA was extracted from cultured cells using TRIzol ® reagent (Invitrogen; Thermo Fisher Scientific, Inc.). Single-stranded complementary (c)DNA was generated from DNaseI-treated RNA samples using Moloney murine leukemiavirus reverse transcriptase and oligo(dT) [12][13][14][15][16][17][18] (Toyobo Life Science, Osaka, Japan). A total of 1 µl cDNA samples were used for conventional PCR amplifications.…”

Section: H-fabp Small Interfering (Si)rna Transfectionmentioning

confidence: 99%

“…To date, at least 10 genes encoding FABPs have been identified in the human genome (FABP1-9 and FABP12). FABPs have been indicated to have a wide range of homology (between 20 and 70% in amino acid sequences) but have similar tertiary structures (12). FABPs all contain a 10-stranded antiparallel β-barrel structure.…”

Section: Si-h-fabp Reduces Pa-induced Oxidative Stress In Podocytesmentioning

confidence: 99%

Overexpression of heart-type fatty acid binding protein enhances fatty acid-induced podocyteï¿½injury

et al. 2017

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Abstract. Deregulated lipid metabolism is a characteristic of metabolic diseases including type 2 diabetes and obesity, and likely contributes to podocyte injury and end-stage kidney disease. Heart-type fatty acid binding protein (H-FABP) was reported to be associated with lipid metabolism. The present study investigated whether H-FABP contributes to podocyte homeostasis. Podocytes were transfected by lentiviral vector to construct a cell line which stably overexpressed H-FABP. Small interfering RNA capable of effectively silencing H-FABP was introduced into podocytes to construct a cell line with H-FABP knockdown. Certain groups were treated with palmitic acid (PA) and the fat metabolism, as well as inflammatory and oxidative stress markers were measured. PA accelerated lipid metabolism derangement, inflammatory reaction and oxidative stress in podocytes. Overexpression of H-FABP enhanced the PA-induced disequilibrium in podocytes. The mRNA and protein expression levels of acyl-coenzyme A oxidase 3 and monocyte chemotactic protein 1, and the protein expression levels of 8-hydroxy-2'-deoxyguanosine and 4-hydroxynonenal were upregulated in the H-FABP overexpression group, while the mRNA and protein expression of peroxisome proliferator activated receptor α was downregulated. Knockdown of H-FABP inhibited the PA-induced injury and lipid metabolism derangement, as well as the inflammatory reaction and oxidative stress in podocytes. These results indicated that overexpression of H-FABP enhances fatty acid-induced podocyte injury, while H-FABP inhibition may represent a potential therapeutic strategy for the prevention of lipid metabolism-associated podocyte injury.

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Fatty acid binding proteins and the nervous system: Their impact on mental conditions

Cited by 47 publications

References 72 publications

Transcriptional control of neural crest specification into peripheral glia

Transcriptional control of neural crest specification into peripheral glia

Possible relationship between common genetic variation and white matter development in a pilot study of preterm infants

Overexpression of heart-type fatty acid binding protein enhances fatty acid-induced podocyteï¿½injury

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