Hippocampal Abnormalities in an MR Imaging Series of Patients with Tuberous Sclerosis

Gama, Hugo Pereira Pinto; Rocha, Antônio José da; Valério, Rosa; Silva, C.J. da; Garcia, Leonardo

doi:10.3174/ajnr.a1972

Cited by 17 publications

(16 citation statements)

References 30 publications

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“…Finally, after reading the full texts, 13 studies properly covered the topic, met the abovedescribed inclusion criteria, and were included in the present review. Among the abovementioned 13 studies, seven studies report information on epilepsy frequency in subjects with IHI and were selected for the estimation of the OR of epilepsy 4,14,[19][20][21][22][23] ; seven full texts were retrospective cohort studies regarding samples of subjects with MCD and hippocampal anomalies, including malrotation, 4,6,7,[24][25][26][27] and were included to calculate the prevalence of IHI in cortical malformations. One of the abovementioned articles 4 provided information about both explored outcomes, thus being included for both the estimation of OR and the prevalence of IHI in MCD.…”

Section: Identification Of Studiesmentioning

confidence: 99%

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Incomplete hippocampal inversion and epilepsy: A systematic review and meta‐analysis

et al. 2020

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Objective Incomplete hippocampal inversion (IHI) is a relatively frequent radiological finding at visual inspection in both epilepsy and healthy controls, but its clinical significance is unclear. Here, we systematically retrieve and assess the association between epilepsy and IHI using a meta‐analytic approach. Additionally, we estimate the prevalence of IHI in patients with malformation of cortical development (MCD). Methods We systematically searched two databases (Embase and PubMed) to identify potentially eligible studies from their inception to December 2019. For inclusion, studies were population‐based, case–control, observational studies reporting on epilepsy and IHI. The risk of developing epilepsy in IHI (estimated with odds ratio [ORs]) and the frequency of IHI among patients with MCD are provided. Results We screened 3601 records and assessed eligibility of 2812 full‐text articles. The final material included 13 studies involving 1630 subjects. Seven studies (1329 subjects: 952 epileptic and 377 nonepileptic) were included for the estimation of the risk of developing epilepsy in the presence of IHI. The estimated OR of active epilepsy in IHI was 1.699 (95% confidence interval = 0.880–3.281), with moderate heterogeneity across studies (I2 = 71%). Seven studies (591 patients) provided information about the frequency of IHI in MCD. Up to one third of patients with MCD (27.9%) presented coexistent IHI. Significance The present findings confirm that IHI is commonly observed in patients with MCD especially in periventricular nodular heterotopia or polymicrogyria. However, the estimated OR indicates overall weak increased odds of epilepsy in people with IHI, suggesting that the presence of isolated IHI cannot be considered a strong independent predictor for epilepsy development. Clear‐cut neuroradiological criteria for IHI and advanced postprocessing analyses on structural magnetic resonance imaging scans are recommended to highlight differences between epileptogenic and nonepileptogenic IHI.

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Section: Identification Of Studiesmentioning

confidence: 99%

“…The final material included 13 studies: two prospective 21,22 and 11 retrospective (Tables 1 and 2). 4,6,7,14,19,20,[23][24][25][26][27] The entire population was composed of 1630 subjects. Twelve studies, involving 1356 subjects, provided information about the gender distribution, with 667 males (49.2%) and 689 females (50.8%).…”

Section: Studies Descriptionmentioning

confidence: 99%

Incomplete hippocampal inversion and epilepsy: A systematic review and meta‐analysis

et al. 2020

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“…The term "malformation" was first and only utilized by Baulac et al based on the knowledge of the embryological development of the HF as well as on the presence of these findings in patients with well-defined MCD [8]. However, other authors later abandoned the term because there were no clear histopathological correlations available [9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, MCD findings in the temporal lobe, including abnormalities of mesial temporal structures, were demonstrated by MRI [7]. Later on, variations of HF shape, orientation or positioning were further described in patients with epilepsy [8][9][10][11]13,14]. The term "malformation" was first and only utilized by Baulac et al based on the knowledge of the embryological development of the HF as well as on the presence of these findings in patients with well-defined MCD [8].…”

Section: Discussionmentioning

confidence: 99%

“…Lehéricy et al previously suggested that HF abnormalities might be the consequence of cortical developmental disorders in some patients [7]. This hypothesis was later reconsidered by other authors who observed that MVHF could be seen in patients with MTLE-HS, MCD, or even in healthy subjects [8][9][10][11][12][13][14]. However, the impact of these structural variations on clinical and neurophysiological aspects has been poorly explored.…”

Section: Introductionmentioning

confidence: 94%

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Morphological variations of hippocampal formation in epilepsy: Image, clinical and electrophysiological data

Hamad

Carrete

Bianchin

et al. 2013

Epilepsy & Behavior

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Independent temporal lobe epilepsy in patients with tuberous sclerosis complex

Liu

Ding

Zhang

et al. 2022

Pediatric Investigation

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Tuberous sclerosis complex (TSC) is a rare disease that involves multiple organs, including the brain; approximately 80%–90% of TSC patients exhibit TSC‐associated epilepsy. Independent temporal lobe epilepsy (TLE), TSC‐unrelated epilepsy, is particularly rare in patients with TSC. Here, we describe three patients with TSC with independent TLEs that were confirmed by stereo‐electroencephalography (EEG), postoperative pathological findings, and seizure outcome at follow‐up. The patients were retrospectively enrolled at two centers; their ictal epileptiform discharge onsets were determined using electrode contacts in the hippocampus during stereo‐EEG. The three patients underwent anterior temporal lobectomies and remained seizure‐free at 1–5 years after surgery. Postoperative pathological examinations confirmed hippocampal sclerosis in all three patients. Furthermore, postoperative intelligence quotient improvement was evident in one patient, while the quality of life was improved in two patients at 12 months after surgery.

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Hippocampal Abnormalities in an MR Imaging Series of Patients with Tuberous Sclerosis

Cited by 17 publications

References 30 publications

Incomplete hippocampal inversion and epilepsy: A systematic review and meta‐analysis

Incomplete hippocampal inversion and epilepsy: A systematic review and meta‐analysis

Morphological variations of hippocampal formation in epilepsy: Image, clinical and electrophysiological data

Independent temporal lobe epilepsy in patients with tuberous sclerosis complex

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