Morphological variations of hippocampal formation in epilepsy: Image, clinical and electrophysiological data

Hamad, Ana Paula Andrade; Carrete, Henrique; Bianchin, Marino Muxfeldt; Ferrari-Marinho, Taíssa; Lin, Kátia; Yacubian, Elza Márcia Targas; Vilanova, Luiz Celso Pereira; Garzón, Eliana; Caboclo, Luís Otávio Sales Ferreira; Sakamoto, Américo Ceiki

doi:10.1016/j.yebeh.2012.10.028

Cited by 3 publications

(3 citation statements)

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“…Involvement of the hippocampal formation in the pathogenesis of various FCD subtypes is an open question. Hippocampal abnormalities are found relatively commonly, with 30%–60% being reported in various studies, although consensus is hard to reach due to differences in techniques, patient populations and criteria used (Bernasconi et al, ; Donmez et al, ; Hamad et al, ; Kuchukhidze et al, ; López et al, ; Montenegro et al, ; Mühlebner et al, ). Some common observations, however, emerge.…”

Section: Discussionmentioning

confidence: 99%

“…Some common observations, however, emerge. There is notable clinical correlation between hippocampal abnormalities (in shape, size, positioning) and the occurrence of febrile seizures (Hamad et al, 2013;M€ uhlebner et al, 2016;Tassi et al, 2009), early seizure onset (Bernasconi et al, 2005;Hamad et al, 2013;M€ uhlebner et al, 2016) and learning and cognitive deficits (Kuchukhidze et al, 2010). Authors generally stress difficulties in diagnosing these patients, some of which are initially classified into FCD Type I, FCD Type IIIa or some sort of "mild" dysplasia or heterotopia, while others are only retrospectively identified, with prior diagnosis of temporal lobe epilepsy, sometimes with hippocampal sclerosis suspected at initial examination.…”

Section: Beyond the Neocortex -Hippocampal Involvement In MCDmentioning

confidence: 99%

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Profiles of gene expression in the hippocampal formation of rats with experimentally‐induced brain dysplasia

Kielbinski

Setkowicz

Gzieło

et al. 2018

Developmental Neurobiology

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Malformations of cortical development (MCD) are a common cause of intractable seizures in humans. Among these, focal cortical dysplasia (FCD) poses an outstanding challenge. There are several subtypes of FCD that show significant variation in pathology and clinical presentation. All types exhibit disturbed cortical cytoarchitecture and increased propensity for seizures. The etiology is likely heterogenous, with mutations, specifically in genes related to mammalian target of rapamycin (mTOR), identified in only a subset of cases. A more complex mechanism, in which underlying genetic background interacts with early, pre- or perinatal injury or stress, has been proposed. Here, we used a well-established animal model of developmental malformations similar to MCD, induced by prenatal gamma irradiation. Previously, a significant variation between times of treatment has been shown, resulting in distinct and lasting patterns of dysplasia and differentially altered seizure propensity. We set out to describe the molecular background of these patterns by performing microarray analyses of hippocampal samples obtained from adult rats previously irradiated at distinct time points during gestation: E13, E15, E17 or E19 as well as controls. The analysis was performed in three conditions: naïve, during latent phase after pilocarpine-induced status epilepticus and after 21 days of transauricular electric shocks. A set of 22 transcripts, some with known functions related to brain development, epilepsy and reaction to injury, was found to be altered between these groups across all treatments. We discuss the functional implication of these molecular differences, in an attempt to provide broader temporal and developmental context. © 2018 Wiley Periodicals, Inc. Develop Neurobiol 78: 718-735, 2018.

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Section: Discussionmentioning

confidence: 99%

Section: Beyond the Neocortex -Hippocampal Involvement In MCDmentioning

confidence: 99%

Profiles of gene expression in the hippocampal formation of rats with experimentally‐induced brain dysplasia

Kielbinski

Setkowicz

Gzieło

et al. 2018

Developmental Neurobiology

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“…The strongest association appears to be with malformation of cortical development and the hippocampal sclerosis is often considered only as a consequence of the epilepsy. Patients with pure morphological variations of hippocampal formation show a higher incidence of extra-temporal seizure onset and have a lower risk of drug-resistance [52]. Hippocampal dysgenesis thus does not provide information on the location of the ictal onset zone with as many precisions as an hippocampal sclerosis does.…”

Section: 3mentioning

confidence: 99%

Morphological imaging of the hippocampus in epilepsy

Isnard¹,

Bourdillon

2015

Revue Neurologique

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